Methanesulfonic acid (E)-octadec-9-enyl ester | 72641-08-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Methanesulfonic acid (E)-octadec-9-enyl ester
• 英文别名: 9-Octadecen-1-ol, methanesulfonate, (9Z)-；octadec-9-enyl methanesulfonate
• CAS: 72641-08-8
• 化学式: C₁₉H₃₈O₃S
• 分子量: 346.575
• InChiKey: SFCVHVDJESFESU-UHFFFAOYSA-N

物化性质

• 沸点：
  465.7±24.0 °C(Predicted)
• 密度：
  0.954±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  23
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methanesulfonic acid (E)-octadec-9-enyl ester 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以88%的产率得到9-十八碳烯基碘
  参考文献：
  名称：

  Synthesis of Pyridinium Amphiphiles Used for Transfection and Some Characteristics of Amphiphile/DNA Complex Formation

  摘要：

  DOI：

  10.1002/(sici)1099-0690(200002)2000:4<665::aid-ejoc665>3.0.co;2-a
• 作为产物：
  描述：

  油醇 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以96%的产率得到Methanesulfonic acid (E)-octadec-9-enyl ester
  参考文献：
  名称：

  Synthesis of Pyridinium Amphiphiles Used for Transfection and Some Characteristics of Amphiphile/DNA Complex Formation

  摘要：

  DOI：

  10.1002/(sici)1099-0690(200002)2000:4<665::aid-ejoc665>3.0.co;2-a

文献信息

• Materials and Complexes for the Delivery of Biologically-Active Materials to Cells
  申请人：Hart Stephen Lewis

  公开号：US20100184831A1

  公开（公告）日：2010-07-22

  The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG) q -Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain) o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q=1, 2 or 3; o denotes the number of hydrophobic chains and o=1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.

  该发明提供了一个公式为A-B-C的肽衍生物，其中A是多阳离子核酸结合组分；B是易在细胞内被裂解的间隔元素肽；C是细胞表面受体结合组分。该发明还提供了一个一般公式(I)的脂质衍生物：(PEG)q-连接物-间隔物-阳离子头基-碳骨架-(疏水链)o，其中：连接物是易在细胞内被裂解的基团；间隔物是连接连接物和阳离子头基的基团；q表示PEG链的数量，q=1、2或3；o表示疏水链的数量，o=1、2或3；碳骨架是将疏水链连接到阳离子头基的基团。这些肽和脂质衍生物可用于非病毒基因传递系统。
• [EN] CATIONIC LIPIDS AND USES THEREOF<br/>[FR] LIPIDES CATIONIQUES ET UTILISATIONS DE CEUX-CI
  申请人：ABBOTT LAB

  公开号：WO2009129385A1

  公开（公告）日：2009-10-22

  Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

  阳离子脂质、基于阳离子脂质的药物传递系统、制备它们的方法以及利用它们治疗疾病的方法被披露。
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ADMINISTRER DES AGENTS THÉRAPEUTIQUES
  申请人：MODERNATX INC

  公开号：WO2017099823A1

  公开（公告）日：2017-06-15

  This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

  这项披露提供了改进的基于脂质的组合物，包括脂质纳米粒子组合物，以及它们用于体内传递药剂的方法，包括核酸和蛋白质。这些组合物不受加速血清清除的影响，并且它们在体内具有改进的毒性特性。
• CATIONIC LIPID
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：US20140294978A1

  公开（公告）日：2014-10-02

  The present invention provides a cationic lipid and the like. The cationic lipid is for delivering a medicament containing a cationic lipid which facilitates the introduction of a nucleic acid into a cell or the like, and is represented by formula (I). In the formula, R 1 is linear or branched alkyl, alkenyl, or alkynyl, each having 8 to 24 carbon atoms, R 2 is linear or branched alkyl, alkenyl, or alkynyl, each having 8 to 24 carbon atoms, or alkoxyethylene, alkoxypropylene, alkenyloxyethylene, alkenyloxypropylene, alkynyloxyethylene, or alkynyloxypropylene, R 3 and R 4 may be the same or different, and are each alkyl having 1 to 3 carbon atoms or are combined together to form alkylene having 2 to 6 carbon atoms, or R 3 and R 5 are combined together to form alkylene having 2 to 6 carbon atoms, R 5 is a hydrogen atom, alkyl having 1 to 6 carbon atoms, alkenyl having 3 to 6 carbon atoms, amino, monoalkylamino, hydroxy, alkoxy, carbamoyl, monoalkylcarbamoyl, dialkylcarbamoyl, or the like, or is combined together with R 3 to form alkylene having 2 to 6 carbon atoms, X is alkylene having 1 to 6 carbon atoms, and Y is a single bond, alkylene having 1 to 6 carbon atoms, or the like.

  本发明提供了一种阳离子脂质等。该阳离子脂质用于传递含有阳离子脂质的药物，有助于将核酸引入细胞或类似物中，并由式(I)表示。在该式中，R1为具有8到24个碳原子的线性或支链烷基、烯基或炔基，R2为具有8到24个碳原子的线性或支链烷基、烯基或炔基，或者为烷氧乙烯、烷氧丙烯、烯氧乙烯、烯氧丙烯、炔氧乙烯或炔氧丙烯，R3和R4可以相同也可以不同，分别为具有1到3个碳原子的烷基，或者结合在一起形成具有2到6个碳原子的烷基，或者R3和R5结合在一起形成具有2到6个碳原子的烷基，R5为氢原子、具有1到6个碳原子的烷基、具有3到6个碳原子的烯基、氨基、单烷基氨基、羟基、烷氧基、氨基甲酰基、单烷基氨基甲酰基、二烷基氨基甲酰基等，或者与R3结合在一起形成具有2到6个碳原子的烷基，X为具有1到6个碳原子的烷基，Y为单键、具有1到6个碳原子的烷基等。
• [EN] REVERSE HEAD GROUP LIPIDS, LIPID PARTICLE COMPOSITIONS COMPRISING REVERSE HEADGROUP LIPIDS, AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS<br/>[FR] LIPIDES À TÊTES POLAIRES INVERSÉES, COMPOSITIONS PARTICULAIRES LIPIDIQUES COMPRENANT LES LIPIDES À TÊTES POLAIRES INVERSÉES, ET PROCÉDÉS D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2011056682A1

  公开（公告）日：2011-05-12

  The present invention related to a novel class of zwitterionic lipids that are useful in the preparation of lipid particles suitable for the delivery of encapsulated nucleic acids to cells.

  本发明涉及一种新型的带电离子脂质类物质，可用于制备适用于将封装的核酸传递至细胞的脂质粒子。