N-(2-methyl-acryloyl)-phenylalanine | 10324-83-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-methyl-acryloyl)-phenylalanine
• 英文别名: N-methacryloyl-phenylalanine；N-Methacryloyl-phenylalanin；n-Methacryloyl-(+/-)-phenylalanin；4-Methacryloyl-DL-phenylalanin；2-(2-Methylprop-2-enoylamino)-3-phenylpropanoic acid
• CAS: 10324-83-1
• 化学式: C₁₃H₁₅NO₃
• 分子量: 233.267
• InChiKey: HIZGPVWGTSAEKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  470.8±45.0 °C(Predicted)
• 密度：
  1.162±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-methyl-acryloyl)-phenylalanine 在 吡啶 作用下， 以 乙酸酐 为溶剂， 生成 4-benzylidene-2-isopropyl-4H-oxazol-5-one
  参考文献：
  名称：

  5-恶唑酮异构体的分离及其结构的核磁共振波谱分析

  摘要：

  在由 N-甲基丙烯酰基-α-氨基酸合成 5-恶唑酮（2-异丙烯基-4-烷基-2-恶唑啉-5-酮）的过程中，获得了新的异构化恶唑酮。通过核磁共振光谱，异构化恶唑酮的结构被确定为假恶唑酮（2-isopropidene-4-烷基-3-恶唑啉-5-ones）。测量了几种假恶唑酮的核磁共振谱，并与正常恶唑酮进行了比较。

  DOI：

  10.1246/bcsj.40.149
• 作为产物：
  描述：

  DL-苯丙氨酸 、 甲基丙烯酰氯 在 sodium hydroxide 作用下， 生成 N-(2-methyl-acryloyl)-phenylalanine
  参考文献：
  名称：

  Synthesis of N-[1-(1-substituted 2-oxopropyl)]acrylamides and -methylacrylamides. Isolation and some reactions of intermediates of the Dakin-West reaction

  摘要：

  DOI：

  10.1021/jo01288a039

文献信息

• DRUG DELIVERY VEHICLES, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF
  申请人：Thayumanavan Sankaran

  公开号：US20110200675A1

  公开（公告）日：2011-08-18

  Drug delivery vehicles that release one or more drugs, e.g., an opioid antagonist and/or an opioid, in response to changes in the chemistry of body fluids, specifically in response to changes in the partial pressure of CO 2 in the environment of the hydrogel are described. The drug delivery vehicles include hydrogels that swell or shrink in response to changes in the partial pressure of CO 2 in their environment, thus regulating release of an entrapped drug.

  本文描述了一种药物递送载体，该载体可以在体液化学变化，特别是在二氧化碳分压环境变化的情况下释放一个或多个药物，例如阿片拮抗剂和/或阿片类药物。这些药物递送载体包括水凝胶，水凝胶可以在其环境中二氧化碳分压的变化下膨胀或收缩，从而调节所包含药物的释放。
• AMINO ACID-BASED POLYMERIZABLE COMPOUNDS AND OPHTHALMIC DEVICES PREPARED THEREFROM
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20210388142A1

  公开（公告）日：2021-12-16

  Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R 1 , and R 2 are as described herein.

  提供了基于氨基酸的可聚合化合物及其在眼科设备中的应用。该基于氨基酸的可聚合化合物的化学式为I：其中R，R1和R2如本文所述。
• BONDING METHOD, BONDING KIT, AND BONDING MATERIAL
  申请人：Tokuyama Dental Corporation

  公开号：EP3165215A1

  公开（公告）日：2017-05-10

  To enable firm bonding to a member including a polyaryl ether ketone resin. A bonding method including: a bonding material applying step for applying, to the surface of a member including a polyaryl ether ketone resin, a bonding material including (A) a polymerizable monomer and (B) at least a portion of components for configuring a polymerization initiator, the content ratio of polymerizable monomers at least having two or more polymerizable functional groups in a (p2) molecule among all polymerizable monomers being 50% by mass or greater, and the content ratio of polymerizable monomers at least having one or more polymerizable functional groups and one or more functional groups capable of hydrogen bonding in a (p1h1) molecule being 5% by mass or greater; and a curing step for curing the bonding material. A bonding material and bonding kit using the bonding method.

  使包括聚芳醚酮树脂在内的构件能够牢固粘接。粘接方法包括粘合材料涂敷步骤，用于在包括聚芳醚酮树脂的构件表面涂敷粘合材料，粘合材料包括 (A) 可聚合单体和 (B) 至少一部分用于配置聚合引发剂的组分、在所有可聚合单体中，(p2)分子中至少具有两个或两个以上可聚合官能团的可聚合单体的含量比为 50%（质量比）或以上，(p1h1)分子中至少具有一个或一个以上可聚合官能团和一个或一个以上能够氢键结合的官能团的可聚合单体的含量比为 5%（质量比）或以上；以及用于固化粘接材料的固化步骤。使用该粘合方法的粘合材料和粘合试剂盒。
• Bonding method, bonding kit, and bonding material
  申请人：Shimizu Tomonao

  公开号：US10285914B2

  公开（公告）日：2019-05-14

  To enable firm bonding to a member including a polyaryl ether ketone resin. A bonding method including: a bonding material applying step for applying, to the surface of a member including a polyaryl ether ketone resin, a bonding material including (A) a polymerizable monomer and (B) at least a portion of components for configuring a polymerization initiator, the content ratio of polymerizable monomers at least having two or more polymerizable functional groups in a (p2) molecule among all polymerizable monomers being 50% by mass or greater, and the content ratio of polymerizable monomers at least having one or more polymerizable functional groups and one or more functional groups capable of hydrogen bonding in a (p1h1) molecule being 5% by mass or greater; and a curing step for curing the bonding material. A bonding material and bonding kit using the bonding method.

  使包括聚芳醚酮树脂在内的构件能够牢固粘接。粘接方法包括粘合材料涂敷步骤，用于在包括聚芳醚酮树脂的构件表面涂敷粘合材料，粘合材料包括 (A) 可聚合单体和 (B) 至少一部分用于配置聚合引发剂的组分、在所有可聚合单体中，(p2)分子中至少具有两个或两个以上可聚合官能团的可聚合单体的含量比为 50%（质量比）或以上，(p1h1)分子中至少具有一个或一个以上可聚合官能团和一个或一个以上能够氢键结合的官能团的可聚合单体的含量比为 5%（质量比）或以上；以及用于固化粘接材料的固化步骤。使用该粘合方法的粘合材料和粘合试剂盒。
• A novel preparation of pseudoxazolones
  作者：Yoshio Iwakura、Fujio Toda、Yoshinori Torii

  DOI：10.1016/s0040-4039(00)70054-2

  日期：1966.1