4-(but-2-en-2-yl)morpholine | 13809-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(but-2-en-2-yl)morpholine
• 英文别名: 4-(1-methyl-propenyl)-morpholine；2-Morpholino-buten-(2)；2-Morpholino-but-2-en；4-but-2-en-2-ylmorpholine
• CAS: 13809-02-4
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: JDHCPDSKMGUEOJ-UHFFFAOYSA-N

物化性质

• 沸点：
  75-80 °C(Press: 20 Torr)
• 密度：
  0.946±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(but-2-en-2-yl)morpholine 、 丙酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 生成 3-methyl-2,4-hexanedione
  参考文献：
  名称：

  Jacquier,R. et al., Bulletin de la Societe Chimique de France, 1966, p. 2971 - 2977

  摘要：

  DOI：

文献信息

• EPOTHILONE DERIVATIVES
  申请人：Vite D. Gregory

  公开号：US20070255055A1

  公开（公告）日：2007-11-01

  The present invention relates to compounds of the formula Q is selected from the group consisting of G is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo, W is O or NR 15 ; X is O or H,H; Y is selected from the group consisting of O; H,OR 16 ; OR 17 ,OR 17 ; NOR 18 ; H,NOR 19 ; H,NR 20 R 21 ; H,H; or CHR 22 ; OR 17 OR 17 can be a cyclic ketal; Z 1 and Z 2 are selected from the group consisting of CH 2 , O, NR 23 , S, or SO 2 , wherein only one of Z and Z 2 is a heteroatom; B 1 and B 2 are selected from the group consisting of OR 24 , or OCOR 25 , or O 2 CNR 26 R 27 ; when B 1 is H and Y is OH, H they can form a six-membered ring ketal or acetal; D is selected from the group consisting of NR 28 R 29 , NR 30 COR 31 or saturated heterocycle; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 13 , R 14 , R 18 , R 19 , R 20 , R 21 , R 22 , R 26 , and R 27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R 1 and R 2 are alkyl can be joined to form a cycloalkyl; R 3 and R 4 are alkyl can be joined to form a cycloalkyl; R 9 , R 10 , R 16 , R 17 , R 24 , R 25 , and R 31 are selected from the group H, alkyl, or substituted alkyl; R 8 , R 11 , R 12 , R 28 , R 30 , R 32 , R 33 , and R 30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo; R 15 , R 23 and R 29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R 32 C═O, R 33 SO 2 , hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds wherein W and X are both O; and R 1 , R 2 , R 7 , are H; and R 3 , R 4 , R 6 , are methyl; and R 8 , is H or methyl; and Z 1 , and Z 2 , are CH 2 ; and G is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; and Q is as defined above are excluded.

  本发明涉及以下化合物的公式：其中Q选自G选自烷基，取代烷基，取代或未取代芳基，杂环烷基，W为O或NR15；X为O或H；Y选自O，H，OR16，OR17，NOR18，H，NOR19，H，NR20R21，H，H或CHR22；OR17OR17可以是环状缩酮；Z1和Z2选自CH2，O，NR23，S或SO2，其中仅Z和Z2中的一个为杂原子；B1和B2选自OR24，或OCOR25，或O2CNR26R27；当B1为H且Y为OH时，它们可以形成六元环缩酮或缩醛；D选自NR28R29，NR30COR31或饱和杂环；R1，R2，R3，R4，R5，R6，R7，R13，R14，R18，R19，R20，R21，R22，R26和R27选自H，烷基，取代烷基或芳基，当R1和R2为烷基时，可以连接成环烷基；R3和R4为烷基时，可以连接成环烷基；R9，R10，R16，R17，R24，R25和R31选自H，烷基或取代烷基；R8，R11，R12，R28，R30，R32，R33和R30选自H，烷基，取代烷基，芳基，取代芳基，环烷基或杂环烷基；R15，R23和R29选自H，烷基，取代烷基，芳基，取代芳基，环烷基，杂环烷基，R32C═O，R33SO2，羟基，O-烷基或O-取代烷基，其药学上可接受的盐和任何水合物，溶剂化合物或其几何，光学和立体异构体，但其中W和X都是O；并且R1，R2，R7为H；并且R3，R4，R6为甲基；并且R8为H或甲基；并且Z1和Z2为CH2；并且G为1-甲基-2-（取代-4-噻唑基）乙烯基；并且Q如上所定义被排除在外。
• Epothilone derivatives
  申请人：Vite D. Gregory

  公开号：US20060287371A1

  公开（公告）日：2006-12-21

  The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B 1 , B 2 , Z 1 , Z 2 , and R 1 -R 7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.

  本发明涉及公式中的化合物，其中变量G、W、Q、X、Y、B1、B2、Z1、Z2和R1-R7的定义如本文所述，以及其衍生物和中间体的制备方法。
• Heterocyclic compounds and their production
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0503958A2

  公开（公告）日：1992-09-16

  Heterocyclic compounds selected from the group consisting of the compounds [IV] to [VII], [IX] and [X]. The heterocyclic compounds are useful for reactive materials in chemical industry and a process for producing the heterocyclic compounds.

  从化合物[IV]至[VII]、[IX]和[X]组成的组中选出的杂环化合物。这些杂环化合物可用作化学工业中的反应材料，也可用于杂环化合物的生产工艺。
• New version of multicomponent condensation leading to 3-amino-2-acyl-4,5,6-trimethylthieno[2,3-b]pyridines
  作者：I. V. Dyachenko

  DOI：10.1134/s107042801511010x

  日期：2015.11

  3-Amino-2-acyl-4,5,6-trimethylthieno[2,3-b]pyridines were synthesized by multicomponent condensation of acetaldehyde, cyanothioacetamide, 4-(but-2-en-2-yl)-morpholine, and a-haloketones.
• US5496943A
  申请人：——

  公开号：US5496943A

  公开（公告）日：1996-03-05