3-(trichlorogermyl)butanoic acid | 21187-26-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(trichlorogermyl)butanoic acid
• 英文别名: Butanoic acid, 3-(trichlorogermyl)-；3-trichlorogermylbutanoic acid
• CAS: 21187-26-8
• 化学式: C₄H₇Cl₃GeO₂
• 分子量: 266.047
• InChiKey: MUJDREPOQOZYKI-UHFFFAOYSA-N

物化性质

• 熔点：
  78-79 °C
• 沸点：
  274.1±42.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.51
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(trichlorogermyl)butanoic acid 在 甲基碘化镁 作用下， 以 乙醚 为溶剂， 以68-80的产率得到3-(trimethylgermyl)butanoic acid
  参考文献：
  名称：

  Synthesis and properties of germa-γ-lactones

  摘要：

  DOI：

  10.1016/0022-328x(90)87287-n
• 作为产物：
  描述：

  巴豆酸 、 三氯锗烷 反应 12.0h， 生成 3-(trichlorogermyl)butanoic acid
  参考文献：
  名称：

  Synthesis and synergetic anti-tumor activity evaluation of dihydroartemisinin-organogermanium(IV) compound

  摘要：

  Dihydroartemisinin (DHA), a semi-synthetic derivative of the herb artemisinin, has shown commendable bioactivity. In this paper, a novel dihydroartemisinin-organogermanium (DHA-Ge) compound was synthesized, characterized and its potential anti-tumor activity was evaluated by various methods. MTT results demonstrated that DHA-Ge could effectively inhibit the proliferation of HepG2 cells and showed their dose-dependent properties. The IC50 value of inhibition effect on HepG2 cells of DHA-Ge was 10.23 mu g/ml which was lower than 39.44 mu g/ml of DHA. Flow cytometric results suggested that DHA-Ge could induce apoptosis of HepG2 cells and the apoptosis rate was 20.26% after 24 h treatment with 56.8 mu g/ml DHA-Ge concentration. Atomic force microscopy images showed that HepG2 cells were collapsed and the cell nucleus were fragmented after 24 h treatment. All these results together showed that the DHA-Ge possessed desirable synergetic enhanced anti-tumor effects and could be developed as a suitable tumor therapeutic agent. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.09.048

文献信息

• Alkyl‐GeMe ₃ : Neutral Metalloid Radical Precursors upon Visible‐Light Photocatalysis
  作者：Qing‐Hao Xu、Li‐Pu Wei、Bin Xiao

  DOI：10.1002/anie.202115592

  日期：2022.3.28

  Alkyl-GeMe3 was proven to be an effective radical precursor under visible-light photocatalysis. The metalloid nature of Ge allows single-electron transfer (SET) at the neutral Ge center and leads to advantages in separation and derivatization.

  在可见光光催化下，烷基-GeMe 3被证明是一种有效的自由基前体。Ge 的准金属性质允许在中性 Ge 中心进行单电子转移 (SET)，并在分离和衍生化方面具有优势。
• Mironov, V. F.; Nuridzhanyan, A. K.; Feoktistov, A. E., Journal of general chemistry of the USSR, 1990, vol. 60, p. 125 - 127
  作者：Mironov, V. F.、Nuridzhanyan, A. K.、Feoktistov, A. E.

  DOI：——

  日期：——
• Synthesis, Spectral (FT‐IR, ¹H, ¹³C, ¹¹⁹Sn) and Biological Studies of Bimetallic Trimethyltin(IV) Germapropionates: X‐Ray Structure of (CH₃)₃Sn(C₂₂H₂₁O₂Ge)
  作者：Muhammad Kaleem Khosa、Muhammad Mazhar、Saqib Ali、Sarim Dastgir、Masood Parvez、Abdul Malik

  DOI：10.1080/15533170701301470

  日期：2007.4.1

  New compounds of bimetallic trimethyltin(IV) germapropionates have been synthesized and characterized by elemental analyses, FT-IR, and multinuclear nmr (H-1,C-13,Sn-119) spectroscopies. These compounds show four-coordinated structure in solution and penta-coordinated structure in solid state. The crystal structure of representative compound, (CH3)(3)Sn(C-22 H-21 O-2 Ge), shows one dimensional polymeric penta-coordinated structure in its solid state. The synthesized compounds were subjected for a bioassay screening and show promising antibacterial and antifungal activities.
• MIRONOV, V. F.;NURIDZHANYAN, A. K.;FEOKTISTOV, A. E., ZH. OBSHCH. XIMII, 60,(1990) N, S. 143-146
  作者：MIRONOV, V. F.、NURIDZHANYAN, A. K.、FEOKTISTOV, A. E.

  DOI：——

  日期：——
• KAKIMOTO, NORIHIRO;YOSHIWARA, TOHRU;AKIBA, MITSUO;ISHIDO, YOSHIHARU, J. ORGANOMET. CHEM., 385,(1990) N, C. 247-254
  作者：KAKIMOTO, NORIHIRO、YOSHIWARA, TOHRU、AKIBA, MITSUO、ISHIDO, YOSHIHARU

  DOI：——

  日期：——