4-(1-Oxo-indan-2-ylidenemethyl)-benzoic Acid | 1393687-56-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4-(1-Oxo-indan-2-ylidenemethyl)-benzoic Acid
• 英文别名: 4-(1Oxo-indan-2-ylidenemethyl)-benzoic acid；4-[(E)-(1,3-Dihydro-1-oxo-2H-inden-2-ylidene)methyl]benzoic acid；4-[(E)-(3-oxo-1H-inden-2-ylidene)methyl]benzoic acid
• CAS: 1393687-56-3
• 化学式: C₁₇H₁₂O₃
• 分子量: 264.28
• InChiKey: ZKHJNABQNGURHC-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2,3-茚满三酮 、 肌氨酸 、 4-(1-Oxo-indan-2-ylidenemethyl)-benzoic Acid 以 甲醇 为溶剂， 反应 0.05h， 以89%的产率得到4'-(4-carboxyphenyl)-1'-methyldispiro[indan-2,2' pyrrolidine-3',2''-indan]-1,3,1''-trione
  参考文献：
  名称：

  Antimycobacterial activity: A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines

  摘要：

  A series of twelve dispiropyrrolidines were synthesized using [3+2]-cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H(37)Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1 mu M. Compound 4'-[5-(4-fluorophenyl) pyridin-3-yl]-1'-methyldispiro[indan-2,2' pyrrolidine-3',2 ''-indan]-1,3,1 ''-trione (4b) was found to be the most active with MIC of 0.1215 and 5.121 mu M, respectively. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.047
• 作为产物：
  描述：

  对醛基苯甲酸 、 1-茚酮 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 以57%的产率得到4-(1-Oxo-indan-2-ylidenemethyl)-benzoic Acid
  参考文献：
  名称：

  Inhibitors of histone deacetylase

  摘要：

  本发明涉及组蛋白去乙酰化酶的抑制。本发明提供了用于抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和状况的药物组合物和方法。

  公开号：

  US06897220B2

文献信息

• [EN] INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] INHIBITEURS DE L'HISTONE DEACETYLASE
  申请人：METHYLGENE INC

  公开号：WO2004069823A1

  公开（公告）日：2004-08-19

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  该发明涉及抑制组蛋白去乙酰化酶的技术。该发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。该发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines acting as antimycobacterial agents
  作者：Ang Chee Wei、Mohamed Ashraf Ali、Yeong Keng Yoon、Rusli Ismail、Tan Soo Choon、Raju Suresh Kumar

  DOI：10.1016/j.bmcl.2012.12.069

  日期：2013.3

  A series of fourteen dispiropyrrolidines were synthesized using [3+2]-cycloaddition reactions and were screened for their antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv in HTS (High Throughput Screen). Most of the compounds showed moderate to good activity with MIC of less than 20 mu M. Compound 4'-(4-bromophenyl)-1'-methyldispiro[acenaphthylene-1,2'-pyrrolidine-3',2 ''-indane]-2',1 ''(1H)-dione (4c) was found to be the most active with MIC of 12.50 mu M. (c) 2013 Elsevier Ltd. All rights reserved.
• Improvements in or relating to radiation sensitive plates
  申请人：VICKERS PLC

  公开号：EP0125140B1

  公开（公告）日：1988-12-14
• Improvements in or relating to perester compounds
  申请人：VICKERS PLC

  公开号：EP0125875B1

  公开（公告）日：1988-08-10
• CHIRAL PHOTOISOMERIZABLE COMPOUNDS
  申请人：Merck Patent GmbH

  公开号：EP1339812B1

  公开（公告）日：2008-07-16