3-(4-methoxyphenyl)-N-(pyridin-3-ylmethyl)propanamide | 362499-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-methoxyphenyl)-N-(pyridin-3-ylmethyl)propanamide
• CAS: 362499-69-2
• 化学式: C₁₆H₁₈N₂O₂
• 分子量: 270.331
• InChiKey: VSSZIAJZZYSONV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨甲基吡啶 、 3-(4-甲氧苯基)-1-丙醇 在 3-甲基-2-丁酮 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 caesium carbonate 、 1,4-双(二苯基膦)丁烷 作用下， 以 叔丁醇 为溶剂， 反应 24.0h， 以45%的产率得到3-(4-methoxyphenyl)-N-(pyridin-3-ylmethyl)propanamide
  参考文献：
  名称：

  Ruthenium-catalysed oxidation of alcohols to amides using a hydrogen acceptor

  摘要：

  A wider investigation into the synthesis of secondary amides from primary alcohols using a hydrogen acceptor using commercially available [Ru(p-cymene)Cl-2](2) with bis(diphenylphosphino)butane (dppb) as the catalyst. The report looks at over 50 examples with varying functionality and steric bulk, whilst also covering the first reported results using microwave heating to effect the transformation. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.04.017

文献信息

• Ruthenium-catalysed oxidation of alcohols to amides using a hydrogen acceptor
  作者：Andrew J.A. Watson、Russell J. Wakeham、Aoife C. Maxwell、Jonathan M.J. Williams

  DOI：10.1016/j.tet.2014.04.017

  日期：2014.6

  A wider investigation into the synthesis of secondary amides from primary alcohols using a hydrogen acceptor using commercially available [Ru(p-cymene)Cl-2](2) with bis(diphenylphosphino)butane (dppb) as the catalyst. The report looks at over 50 examples with varying functionality and steric bulk, whilst also covering the first reported results using microwave heating to effect the transformation. (C) 2014 Elsevier Ltd. All rights reserved.