1-(2-hydroxy-3-phenoxypropyl)pyrrolidin-2-one | 83356-43-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2-hydroxy-3-phenoxypropyl)pyrrolidin-2-one
• CAS: 83356-43-8
• 化学式: C₁₃H₁₇NO₃
• 分子量: 235.283
• InChiKey: JFGILGRICGLBSF-UHFFFAOYSA-N

物化性质

• 熔点：
  80-82 °C(Solv: hexane (110-54-3))
• 沸点：
  200-205 °C(Press: 1 Torr)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-吡咯烷酮 、 苯基缩水甘油醚 反应 2.0h， 以69%的产率得到1-(2-hydroxy-3-phenoxypropyl)pyrrolidin-2-one
  参考文献：
  名称：

  苯基缩水甘油醚与一些杂环的反应

  摘要：

  The respective hydroxypropyl phenyl ethers were obtained by the reaction of 5,5-dimethylhydantoin, morpholine, benzotriazole, benzimidazole, pyrrolidone, and phthalimide with phenyl glycidyl ether. 8-(2-Hydroxy-3-phenoxy) quinoline was synthesized by O-alkylation.

  DOI：

  10.1007/s10593-008-0093-6

文献信息

• Ultra-short-acting .beta.-adrenergic receptor blocking agents. 1. (Aryloxy)propanolamines containing esters in the nitrogen substituent
  作者：Paul W. Erhardt、Chi M. Woo、Richard J. Gorczynski、William G. Anderson

  DOI：10.1021/jm00354a002

  日期：1982.12

  In an attempt to produce short-acting beta-adrenergic receptor blocking agents, we prepared several (aryloxy)propanolamines with ester functions incorporated into the nitrogen substituent. Many of these compounds exhibited a short duration of blocking activity after their continuous intravenous infusion for 40 min. However, their durations were found to increase considerably upon longer intravenous

  为了产生短效的β-肾上腺素受体阻断剂，我们制备了几种具有酯官能团的（芳氧基）丙醇胺并入氮取代基。这些化合物中的许多在连续静脉输注40分钟后显示出很短的阻断活性。然而，发现它们的持续时间随着更长的静脉内输注而显着增加。
• ERHARDT, P. W.;WOO, CHI, M.;GORCZYNSKI, R. J.;ANDERSON, W. G., J. MED. CHEM., 1982, 25, N 12, 1402-1407
  作者：ERHARDT, P. W.、WOO, CHI, M.、GORCZYNSKI, R. J.、ANDERSON, W. G.

  DOI：——

  日期：——