β-chloroethyl 2-thienyl sulfide | 55697-87-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: β-chloroethyl 2-thienyl sulfide
• 英文别名: (2-Chlorethyl)-(2-thienyl)-sulfid；2-(β-Chlorethylmercapto)-thiophen；1-chloro-2-(thien-2-ylthio)ethane；2-(2-chloroethylthio)thiophene；2-(2-chloro-ethylsulfanyl)-thiophene；1-chloro-2-(2-thienylthio)ethane；Thiophene, 2-[(2-chloroethyl)thio]-；2-(2-chloroethylsulfanyl)thiophene
• CAS: 55697-87-5
• 化学式: C₆H₇ClS₂
• 分子量: 178.707
• InChiKey: QGMBRBQQSIWZPS-UHFFFAOYSA-N

物化性质

• 沸点：
  118-120 °C(Press: 2.5 Torr)
• 密度：
  1.2811 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate 、 β-chloroethyl 2-thienyl sulfide 生成 methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylsulfanyl)-ethyl]piperidine-3-carboxylate
  参考文献：
  名称：

  Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them

  摘要：

  配方（I）的喹诺啉丙基哌啶衍生物，特别有优势的抗微生物药剂，其组成成分和用途。

  公开号：

  US06403610B1
• 作为产物：
  描述：

  2-噻吩硫醇 、 1-溴-2-氯乙烷 在 sodium hydroxide 、 氮气 作用下， 以 乙醚 为溶剂， 生成 β-chloroethyl 2-thienyl sulfide
  参考文献：
  名称：

  Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them

  摘要：

  配方（I）的喹诺啉丙基哌啶衍生物，特别有优势的抗微生物药剂，其组成成分和用途。

  公开号：

  US06403610B1

文献信息

• Use of azacyclic or azabicyclic thiadiazole compounds for treating anxiety
  申请人：ELI LILLY AND COMPANY

  公开号：EP0774256A1

  公开（公告）日：1997-05-21

  The present invention provides a method for treating anxiety in humans using azacyclic or azabicyclic thiadiazole compounds.

  本发明提供了一种治疗人类焦虑症的方法，使用氮杂环或氮杂双环噻二唑化合物。
• Heterocyclic compounds and their preparation and use
  申请人：ELI LILLY AND COMPANY

  公开号：EP0709381A1

  公开（公告）日：1996-05-01

  The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system, and are of formula I or the quarternized form thereof

  本发明涉及具有治疗活性的氮杂环或氮杂双环化合物、制备方法以及包含这些化合物的药物组合物。这些新型化合物可用于治疗因毒蕈碱胆碱能系统功能失调而引起的中枢神经系统疾病，它们是式 I 或其醌化形式
• ——
  作者：O. V. Alekminskaya、N. V. Russavskaya、N. A. Korchevin、E. N. Deryagina

  DOI：10.1023/a:1015397313038

  日期：——

  A convenient preparative synthesis of bis(organylthio)alkanes was developed. It is based on alkylation with dihaloalkanes of solutions of diorganyl disulfides in the basic reductive system hydrazine hydrate-alkali. The generation of organylthiolate anions from disulfides and the subsequent reaction of the anions with dihaloalkanes are performed in one reaction vessel without isolation of intermediate alkali metal thiolates. At the same time, the reactions of diphenyl or dithienyl disulfides with dihaloalkanes result in substitution with the thiolate anions of only one halogen atom to give the corresponding unsymmetrical sulfides. In certain cases in the presence of excess alkali the latter sulfides are dehalogenated to form alkyl vinyl sulfides.
• ——
  作者：N. V. Russavskaya、N. A. Korchevin、O. V. Alekminskaya、E. N. Sukhomazova、E. P. Levanova、E. N. Deryagina

  DOI：10.1023/a:1022540002086

  日期：——

  Reaction of thiols with dihaloalkanes in the system hydrazine hydrate-base leads to alkyl(chloroalkyl) sulfides with different positions of the chlorine atom with respect to sulfur. The developed one-step procedure for the synthesis of such unsymmetrical sulfides is most suitable for arenethiols and alkanethiols having a long polymethylene chain. The reaction mechanism is discussed.
• ETIENNE A.; BAILLS G.; LONCHAMBON G.; DESMAZIERES B., C. R. ACAD. SCI., 1979, C 288, NO 19, 493-498
  作者：ETIENNE A.、 BAILLS G.、 LONCHAMBON G.、 DESMAZIERES B.

  DOI：——

  日期：——