4-{Dimethyl[3-(tetradecanoylamino)propyl]azaniumyl}butane-1-sulfonate | 122398-33-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-{Dimethyl[3-(tetradecanoylamino)propyl]azaniumyl}butane-1-sulfonate
• 英文别名: 4-[dimethyl-[3-(tetradecanoylamino)propyl]azaniumyl]butane-1-sulfonate
• CAS: 122398-33-8
• 化学式: C23H48N2O4S
• 分子量: 448.7
• InChiKey: DJYNLMBZWBLUKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  30
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  94.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• HEMOLYSIS REAGENT COMPOSITION FOR HEMOGLOBIN A1C QUANTITATIVE ANALYSIS USING ENZYMATIC METHOD
  申请人：i-Sens, Inc.

  公开号：EP2813854A1

  公开（公告）日：2014-12-17

  Disclosed is a hemolysis reagent composition for the quantitative analysis of glycated hemoglobin (HbAlc) via an enzymatic method. The hemolysis reagent compositions of the present invention containing a zwitterionic surfactant and a nitrous compound considerably accelerate hemolysis rate due to the presence of the zwitterionic surfactant, and also induce the N-terminal β-chain of hemoglobin released by hemolysis to be exposed to the outside of the hemoglobin molecule and assists the participation of a greater number of molecules in the reaction, thereby improving reaction sensitivity and reaction rate of the glycated hemoglobin, and the nitrous compound makes the protein structure of the hemoglobin flexibly modified so that the amino acid sequence of the N-terminal β-chain of hemoglobin can be readily cut off, thereby significantly reducing the entire time required for the measurement and improving the accuracy of the measurement.

  本发明公开了一种溶血试剂组合物，用于通过酶法定量分析糖化血红蛋白（HbAlc）。本发明的溶血试剂组合物含有一种齐聚物表面活性剂和一种亚硝基化合物，由于齐聚物表面活性剂的存在，大大加快了溶血速率，还能促使溶血释放出的血红蛋白的 N 端 β 链暴露在血红蛋白分子外部，有助于更多的分子参与反应、同时，硝基化合物可使血红蛋白的蛋白质结构发生灵活改变，使血红蛋白 N 端 β 链的氨基酸序列易于切断，从而大大缩短了整个测量所需的时间，提高了测量的准确性。
• KIT FOR HEMOGLOBIN A1C QUANTITATIVE ANALYSIS
  申请人：i-Sens, Inc.

  公开号：EP3527669A1

  公开（公告）日：2019-08-21

  The present invention relates to a kit for quantitative analysis of glycated hemoglobin (HbA1c), and the kit for quantitative analysis of HbA1c according to the present invention has excellent long-term stability of an enzyme reagent and thus has an effect of easily overcoming the disadvantages of the conventional reagents used in enzyme assays (e.g., storage, accuracy, portability, convenience of use, etc.).

  本发明涉及一种糖化血红蛋白（HbA1c）定量分析试剂盒，根据本发明的糖化血红蛋白（HbA1c）定量分析试剂盒具有良好的酶试剂长期稳定性，因此具有轻松克服酶测定中使用的传统试剂的缺点（如储存、准确性、便携性、使用方便等）的效果。
• Methods and compositions for inactivating enveloped viruses
  申请人：Biogen MA Inc.

  公开号：US10188732B2

  公开（公告）日：2019-01-29

  Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.

  本发明的各个方面提供了治疗性重组蛋白制剂和制备治疗性重组蛋白的方法，这些方法包括在洗涤剂的临界胶束浓度或以上将重组蛋白制剂与齐聚物洗涤剂接触。
• Kit for hemoglobin A1C quantitative analysis
  申请人：I-SENS, INC.

  公开号：US11262365B2

  公开（公告）日：2022-03-01

  The present invention relates to a kit for quantitative analysis of glycated hemoglobin (HbA1c), and the kit for quantitative analysis of HbA1c according to the present invention has excellent long-term stability of an enzyme reagent and thus has an effect of easily overcoming the disadvantages of the conventional reagents used in enzyme assays (e.g., storage, accuracy, portability, convenience of use, etc.).

  本发明涉及一种糖化血红蛋白（HbA1c）定量分析试剂盒，根据本发明的糖化血红蛋白（HbA1c）定量分析试剂盒具有良好的酶试剂长期稳定性，因此具有轻松克服酶测定中使用的传统试剂的缺点（如储存、准确性、便携性、使用方便等）的效果。
• METHODS FOR INACTIVATING ENVELOPED VIRUSES
  申请人：Biogen MA Inc.

  公开号：EP2879691B1

  公开（公告）日：2019-03-27