diethyl(iminomethylene) dicarbamate | 31012-24-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl(iminomethylene) dicarbamate
• 英文别名: N,N'-bis-ethoxycarbonyl-guanidine；N,N'-Bis-aethoxycarbonyl-guanidin；Guanidin-N.N'-dicarbonsaeure-diaethylester；Guanidincarbonsaeurediaethylester；N.N'-Dicarbaethoxy-guanidin；ethyl N-(N-ethoxycarbonylcarbamimidoyl)carbamate
• CAS: 31012-24-5
• 化学式: C₇H₁₃N₃O₄
• 分子量: 203.198
• InChiKey: VVZKVJZZDTVKSD-UHFFFAOYSA-N

物化性质

• 熔点：
  162-163 °C
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl(iminomethylene) dicarbamate 在 乙醇 、 氨 作用下， 生成 Guanyl-ethylurethan
  参考文献：
  名称：

  Nencki, Chemische Berichte, 1874, vol. 7, p. 1589

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N'-bis-ethoxycarbonyl-O-ethyl-isourea 在 乙醇 、 氨 作用下， 生成 diethyl(iminomethylene) dicarbamate
  参考文献：
  名称：

  Dains, Journal of the American Chemical Society, 1899, vol. 21, p. 191

  摘要：

  DOI：

文献信息

• Process for the preparation of substituted pyrimidine derivatives
  申请人：Cesco-Cancian Sergio

  公开号：US20100004450A1

  公开（公告）日：2010-01-07

  The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.

  本发明涉及制备取代嘧啶衍生物的过程，该衍生物可用作组胺H4受体调节剂合成中间体，以及H4调节剂合成中间体。
• PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIMIDINE DERIVATIVES
  申请人：Janssen Pharmaceutica NV

  公开号：US20140121374A1

  公开（公告）日：2014-05-01

  The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.

  本发明涉及制备取代嘧啶衍生物的过程，该衍生物在组织胺H4受体调节剂的合成中作为中间体使用，并涉及H4调节剂合成中的中间体。
• Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis
  作者：Mladena Glavaš、Agata Gitlin-Domagalska、Natalia Ptaszyńska、Dominika Starego、Sylwia Freza、Dawid Dębowski、Aleksandra Helbik-Maciejewska、Anna Łęgowska、Chaim Gilon、Krzysztof Rolka

  DOI：10.3390/molecules28237780

  日期：——

  Arginine, due to the guanidine moiety, increases peptides’ hydrophilicity and enables interactions with charged molecules, but at the same time, its presence in a peptide chain might reduce its permeability through biological membranes. This might be resolved by temporary coverage of the peptide charge by lipophilic, enzyme-sensitive alkoxycarbonyl groups. Unfortunately, such a modification of a guanidine

  由于胍部分，精氨酸增加了肽的亲水性并能够与带电分子相互作用，但同时，其存在于肽链中可能会降低其通过生物膜的渗透性。这可以通过亲脂性、酶敏感的烷氧基羰基暂时覆盖肽电荷来解决。不幸的是，迄今为止还没有报道过对胍部分的这种修饰，并且结果证明这是具有挑战性的。在这里，我们提出了一种新的优化策略来获得亲脂性增加的精氨酸结构单元，并成功用于新型精氨酸加压素前药的固相肽合成。
• FLAME-RETARDANT EPOXY RESIN COMPOSITION
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1775321A1

  公开（公告）日：2007-04-18

  Disclosed is a flame-retardant epoxy resin composition characterized by containing (A) an epoxy resin containing 0.5-10 equivalent/kg of oxazolidone rings, (B) an epoxy group-containing phosphazene compound, (C) at least one compound selected from the group consisting of phosphates, condensed phosphates, quinone derivatives of phosphine compounds, and polyphenylene ethers, and (D) at least one curing agent selected from the group consisting of guanidine derivatives, phenol novolacs, bisphenol A novolacs, cresol novolacs and naphthol novolacs.

  公开了一种阻燃环氧树脂组合物，其特征在于含有 (A) 含 0.5-10当量/公斤的噁唑酮环；(B) 含环氧基团的磷氮化合物；(C) 至少一种选自磷酸盐、缩合磷酸盐、膦化合物的醌衍生物和聚苯醚组成的组的化合物；(D) 至少一种选自胍衍生物、苯酚酚醛、双酚A酚醛、甲酚酚醛和萘酚酚醛组成的组的固化剂。
• EPOXY RESIN COMPOSITION
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1867672A1

  公开（公告）日：2007-12-19

  To provide an epoxy resin composition that can afford a printed wiring board excellent in heat resistance, adhesiveness, prepreg storage stability, and insulation reliability. An epoxy resin composition containing (A) an oxazolidone ring-containing epoxy resin, (B) a novolac-type epoxy resin, (C) a guanidine derivative, and (D) an imidazole as components, wherein the component (A) contains an isocyanuric ring as well as an oxazolidone ring and, the IR absorbance ratio of the isocyanuric ring to the oxazolidone ring is not less than 0.01 and not more than 0.1, the weight ratio of the component (A) to the component (B) is 5:95 to 95:5, the content of the component (C) and the content of the component (D) are 0.01 to 5 parts by weight and not more than 0.08 part by weight, respectively, based on 100 parts by weight of the total weight of the epoxy resins containing the component (A) and the component (B), and the bromine content based on a weight obtained by subtracting the weight of the component (C) and the weight of the component (D) from the weight of the resin composition is not less than 10% by weight and not more than 20% by weight.

  提供一种环氧树脂组合物，它能使印刷线路板具有优异的耐热性、粘合性、预浸料贮存稳定性和绝缘可靠性。 一种环氧树脂组合物，含有 (A) 含噁唑烷酮环的环氧树脂、(B) 酚醛型环氧树脂、(C) 胍衍生物和 (D) 咪唑作为组分，其中组分 (A) 既含有异氰脲酸环，也含有噁唑烷酮环，异氰脲酸环与噁唑烷酮环的红外吸收比不小于 0.01且不大于0.1，组分(A)与组分(B)的重量比为5:95至95:5，组分(C)和组分(D)的含量为0.以含有组分(A)和组分(B)的环氧树脂总重量 100 重量份为基准，组分(C)的含量为 0.01 至 5 重量份，组分(D)的含量为不超过 0.08 重量份；以从树脂组合物重量中减去组分(C)和组分(D)的重量所得的重量为基准，溴含量不低于 10%，不超过 20%。