申请人:Cheema Lal
公开号:US20070197519A1
公开(公告)日:2007-08-23
There is provided a process for the preparation of a compound of formula (I): which process comprises reaction of a compound of formula (TI): with either a compound of formula (ITT): or acrylamide, followed, in the latter case, by reaction of the resulting intermediate of formula (IV): with an alcohol of formula R
2
═OH and an agent that promotes, or agents that in combination promote, rearrangement and oxidation of the compound of formula IV to an intermediate isocyanate, which may then react with the alcohol of formula R
2
═OH, and wherein R
1
, R
2
and R
16
have meanings given in the description.
提供了一种制备化合物(I)的方法,该方法包括将化合物(TI)与化合物(ITT)或丙烯酰胺反应,后者情况下,再将生成的中间体(IV)与具有公式R2═OH的醇和促进化合物IV重排和氧化的试剂或组合试剂反应,所述化合物IV可进一步与公式R2═OH的醇反应,其中R1、R2和R16的含义如描述中所给。