N-(4-ethoxycarbonylphenyl)-2-(hydroxyimino)acetamide | 17122-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-ethoxycarbonylphenyl)-2-(hydroxyimino)acetamide
• 英文别名: 4-(α-Oximino-acetamino)-benzoesaeure-ethylester；4-(2-hydroxyimino-acetylamino)-benzoic acid ethyl ester；4-(2-Hydroxyimino-acetylamino)-benzoesaeure-aethylester；N-(4-ethoxycarbonyl-phenyl)-2-hydroximino-acetamide；Ethyl 4-[[2-(hydroxyimino)acetyl]amino]benzoate；ethyl 4-[(2-hydroxyiminoacetyl)amino]benzoate
• CAS: 17122-79-1
• 化学式: C₁₁H₁₂N₂O₄
• 分子量: 236.227
• InChiKey: ZNSCOZPQUDQAEG-UHFFFAOYSA-N

物化性质

• 熔点：
  100 °C
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  88
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(4-ethoxycarbonylphenyl)-2-(hydroxyimino)acetamide 在 盐酸 、 palladium on activated charcoal 作用下， 生成 乙基4-[(2-氨基乙酰基)氨基]苯甲酸酯
  参考文献：
  名称：

  King et al., Journal of the Chemical Society, 1954, p. 1039,1042

  摘要：

  DOI：
• 作为产物：
  描述：

  苯佐卡因 在 盐酸 、 水合氯醛 、 羟胺 、 sodium sulfate 作用下， 生成 N-(4-ethoxycarbonylphenyl)-2-(hydroxyimino)acetamide
  参考文献：
  名称：

  King et al., Journal of the Chemical Society, 1954, p. 1039,1042

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ACUTE MYELOID LEUKEMIA OR METASTATIC BREAST CANCER
  申请人：PELEMED CO., LTD.

  公开号：US20200270229A1

  公开（公告）日：2020-08-27

  The present invention relates to a pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer, comprising, as an active ingredient, an indirubin derivative. When the compound of the present invention is used, it can effectively inhibit the activity of FLT3 kinase and can be usefully used to prevent or treat acute myeloid leukemia or metastatic breast cancer.

  本发明涉及一种用于预防或治疗急性髓样白血病或转移性乳腺癌的药物组合物，其包括一种因地鲁宾衍生物作为活性成分。当使用本发明的化合物时，可以有效抑制FLT3激酶的活性，并可用于预防或治疗急性髓样白血病或转移性乳腺癌。
• 对SARS冠状病毒主蛋白酶具有抑制作用的靛 红-5-酰胺类抑制剂
  申请人：天津市国际生物医药联合研究院

  公开号：CN103159665B

  公开（公告）日：2017-01-25

  本发明提供式(1)所示的靛红‑5‑酰胺类化合物，所述化合物具有SARS冠状病毒主蛋白酶抑制活性，可以用作SARS冠状病毒主蛋白酶抑制剂，在SARS治疗中发挥作用，式(1)化合物结构式如下：。
• 급성 골수성 백혈병 또는 전이성 유방암의 예방 또는 치료용 약제학적 조성물
  申请人：PELEMED CO., LTD. 주식회사 펠레메드(120190402315) Corp. No ▼ 110111-7125845BRN ▼319-81-01407

  公开号：KR20210047850A

  公开（公告）日：2021-04-30

  본 발명은 인디루빈 유도체를 유효 성분으로 포함하는 급성 골수성 백혈병 또는 전이성 유방암의 예방 또는 치료용 약제학적 조성물에 관한 것이다. 본 발명의 조성물을 이용하는 경우 FLT3 키나아제의 활성을 효과적으로 억제하고, 급성 골수성 백혈병 또는 전이성 유방암을 예방 또는 치료하는데 유용하게 사용할 수 있다.

  This invention relates to a pharmaceutical composition for the prevention or treatment of acute myeloid leukemia or metastatic breast cancer, which includes an indirubin derivative as an active ingredient. When using the composition of the present invention, it can effectively inhibit the activity of FLT3 kinase and be useful for preventing or treating acute myeloid leukemia or metastatic breast cancer.
• Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors
  作者：Masafumi Yamagishi、Yoshihisa Yamada、Kenichi Ozaki、Masaaki Asao、Ryo Shimizu、Mamoru Suzuki、Mamoru Matsumoto、Yuzo Matsuoka、Kazuo Matsumoto

  DOI：10.1021/jm00089a021

  日期：1992.5

  A series of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones were prepared and tested for aldose reductase inhibitory activity. The 6'-halogenated derivatives were found to be highly potent in vitro inhibitors of male rabbit lens aldose reductase and in vivo inhibitors of polyol accumulation in the sciatic nerves of galactosemic rats. Of these, (4R)-6'-chloro-3'-methylspiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-trione (67) showed the most potent in vitro and in vivo activities. An oral dose of 3 g/kg of compound 67 caused neither death nor behavioral abnormality in the preliminary acute toxicity study using mice and rats. Compound 67 was selected as a candidate for further evaluation. The quantitative structure-activity relationships in this series are also discussed.
• An improved synthesis of isonitrosoacetanilides
  作者：Gordon W. Rewcastle、Hamish S. Sutherland、Claudette A. Weir、Adrian G. Blackburn、William A. Denny

  DOI：10.1016/j.tetlet.2005.10.046

  日期：2005.12

  A novel two-step synthesis of isonitrosoacetanilides [2-(hydroxyimino)-N-phenylacetamides] has been developed, involving the initial acylation of aniline derivatives with 2,2-diacetoxyacetyl chloride, followed by reaction with hydroxylamine hydrochloride. The method works equally well with a variety of different aniline derivatives, including those with poor aqueous solubility and those containing electron rich ortho-substituents, neither of which react well under traditional conditions. (c) 2005 Elsevier Ltd. All rights reserved.