ergosterol D | 516-84-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ergosterol D
• 英文别名: (3S,5S,10S,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 516-84-7
• 化学式: C₂₈H₄₄O
• 分子量: 396.657
• InChiKey: XSMGJKKUFBTARU-MJXYXNKESA-N

物化性质

• 熔点：
  163 °C
• 沸点：
  505.7±49.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  ergosterol D 在 钯 、 乙酸乙酯 作用下， 生成 菜油甾醇
  参考文献：
  名称：

  EHL Film Thickness Limitation Theory Under a Limiting Shear Stress

  摘要：

  It is numerically shown that the elastohydrodynamic lubrication (EHL) film thickness has a limit under an assumed limiting shear stress of the contact-lubricant interface in isothermal Pure rolling line contacts. The prediction of the central film thickness limit is made, and well matches experiments. The present theory shows that, in elastohydrodynamic line contacts, the central film thickness is of molecular scale and part of the contact area is in non-continuum film lubrication when the equivalent cylinder curvature radius is less than the critical one. This critical radius depends on the load and the contact-lubricant interfacial limiting shear stress at low pressures.

  DOI：

  10.1080/10402000208982584
• 作为产物：
  描述：

  麦角固醇 在 乙醇 、 二氧化碳 、 mercury(II) diacetate 、 sodium 、 镍 、 溶剂黄146 作用下， 生成 ergosterol D
  参考文献：
  名称：

  Windaus; Auhagen, Justus Liebigs Annalen der Chemie, 1929, vol. 472, p. 185,190, 193

  摘要：

  DOI：

文献信息

• Regioselective reductions of steroidal conjugated dienes by DIBAH
  作者：Sara Montiel-Smith、Leticia Quintero-Cortes、Jesús Sandoval-Ramirez

  DOI：10.1016/0040-4039(95)01807-t

  日期：1995.11

  DIBAH reduces sleroidal 5,7and 22,24(28)-conjugated dienes regioselectively in high yields. The reduction of double bond at C-5 affords only 5α-steroids but that of 24(28)-double bond results in epimeric products at C-24. Neither isolated C-5 double bonds nor 7, 9(11)-dienes are transformed

  DIBAH以高产率区域选择性地还原了5,7和22,24（28）-共轭的二烯类化合物。C-5处双键的还原仅提供5α-类固醇，但24（28）-双键的还原导致C-24处的差向异构产物。孤立的C-5双键和7、9（11）-二烯均未转化
• �ber Steroide und Sexualhormone. 197. Mitteilung. �ber die Dehydrierung von ?-Dihydro-ergosterin-acetat mit Quecksilber (II)-acetat und Selendioxyd
  作者：G. Saucy、P. Geistlich、R. Helbling、H. Heusser

  DOI：10.1002/hlca.19540370133

  日期：——

  Bei der Oxydation von Δ7;22 β-Acetoxy-ergostadien (α-Dihydroergosterin-acetat (II)) mit Selendioxyd in Äther-Eisessig entsteht neben dem 8,14-ungesättigten-7 α-Oxy-Derivat Vb ein weiterer, isomerer Allylalkohol. Es konnten Anhaltspunkte dafür gewonnen werden, dass dieser Verbindung die Konstitution eines 7,8-ungesättigten 9-Oxy-ergostan-Derivates IV zukommt. Die beiden Oxydationsprodukte stellen Zwischenstufen

  Δ的氧化7; 22用二氧化硒在乙醚-冰醋酸β乙酰氧基ergostadiene（α-dihydroergosterol乙酸酯（II）），除了产生一个进一步，异构体的烯丙醇到8,14-二不饱和7α-氧衍生物Vb。可以证明该化合物具有7，8-不饱和9-氧麦角锡烷衍生物IV的结构。两种氧化产物代表α-二氢麦角固醇乙酸酯（II）与二氧化硒脱水为麦角甾醇B 3（III）和麦角甾醇D-乙酸酯（I）的中间阶段。
• The Preparation of Δ^7,9(11)-allo-Steroids by the Action of Mercuric Acetate on Δ⁷-allo-Steroids
  作者：W. V. Ruyle、T. A. Jacob、J. M. Chemerda、E. M. Chamberlin、D. W. Rosenburg、G. E. Sita、R. L. Erickson、L. M. Aliminosa、M. Tishler

  DOI：10.1021/ja01107a015

  日期：1953.6
• Film Formation in EHL Point Contacts under Zero Entraining Velocity Conditions
  作者：F. Guo、P. L. Wong、P. Yang、K. Yagi

  DOI：10.1080/10402000208982583

  日期：2002.1

  The contacts of adjacent bulls in a retainerless bearing are subjected to the zero entrainment velocity (ZEV). The existence of an effective elastohydrodynamic lubrication (EHL) film between contacts running tinder ZEV conditions has long been proven experimentally. However, the classical EHL theory predicts a Zero film thickness under ZEV conditions. Mechanisms, such as the thermal viscosity wedge effect and immobile film theory, have been proposed to tentatively explain the phenomenon. However, detailed numerical results are needed to provide theoretical evidence for such film formations. This paper aims to simulate, based on the viscosity wedge mechanism, the film formation of EHL point contacts tinder ZEV conditions. Complete numerical solutions have been successfully obtained. The results show, that the thermal viscosity wedge induces a concave film profile, instead of a parallel film (Hertzian) as postulated by sonic previous researchers. By the simulation solver developed, the variation of film thickness with loads, oil supply conditions and ellipticity, parameters have been investigated. Some unique lubrication behaviors tinder ZEV conditions are demonstrated. Furthermore, preliminary quantitative comparisons with the latest optical EHL experiments are finished. Both results are in good correlation.
• ERGOSTEROL F¹
  作者：WERNER BERGMANN、JOHN A. KLACSMANN

  DOI：10.1021/jo01159a003

  日期：1948.1