3-Chloro-isonitrosoacetanilide | 17122-55-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Chloro-isonitrosoacetanilide
• 英文别名: isonitroso-3-chloroacetanilide；(2E)-N-(3-Chlorophenyl)-2-(hydroxyimino)ethanamide；(2Z)-N-(3-chlorophenyl)-2-hydroxyiminoacetamide
• CAS: 17122-55-3
• 化学式: C₈H₇ClN₂O₂
• 分子量: 198.609
• InChiKey: GONPFFPCDZHBNR-YHYXMXQVSA-N

物化性质

• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  3-Chloro-isonitrosoacetanilide 在 盐酸 、 sodium hydroxide 、 硫酸 作用下， 以 水 为溶剂， 生成 4-氯靛红
  参考文献：
  名称：

  3-Substituted 2-oxindole-1-carboxamides as analgesic and

  摘要：

  某些在3位具有酰基取代基的新2-噁喹啉-1-羧酰胺化合物是环氧合酶（CO）和脂氧合酶（LO）酶的抑制剂，并且在哺乳动物主体中作为镇痛和抗炎药物是有用的。特别是，本发明的化合物对于减轻或消除人类主体在手术或创伤恢复过程中的疼痛���以及缓解慢性疾病症状，如类风湿性关节炎和骨关节炎，对人类主体是有用的。

  公开号：

  US04556672A1
• 作为产物：
  描述：

  水合氯醛 、 3-氯苯胺 在 盐酸 、 羟胺 、 sodium sulfate 作用下， 以 水 为溶剂， 生成 3-Chloro-isonitrosoacetanilide
  参考文献：
  名称：

  Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

  摘要：

  某些新型的2-噁嗪酮化合物，在1-位置和3-位置都有酰基取代基，是环氧合酶（CO）和脂氧合酶（LO）酶的抑制剂，并且在哺乳动物主体中作为镇痛剂和抗炎剂是有用的。这些1,3-二酰基-2-噁嗪化合物对于急性给药在减轻人类手术或创伤恢复中的疼痛方面具有特殊价值，也对于慢性给药给予人类主体以减轻类风湿性关节炎和骨关节炎等慢性疾病症状方面是有益的。

  公开号：

  US04690943A1

文献信息

• N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and
  申请人：Pfizer Inc.

  公开号：US04569942A1

  公开（公告）日：1986-02-11

  Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted phenyl group, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and antiinflammatory agents in mammalian subjects. These 2-oxindole-1-carboxamide compounds are of particular value for ameliorating pain in human patients recovering from surgery or trauma, and alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects. Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having a substituent on the carboxamide nitrogen, are useful as intermediates to the analgesic and antiinflammatory agents of the invention.

  某些在3位上具有酰基取代基，并且在羧酰胺氮上进一步被烷基、环烷基、苯基或取代苯基基团取代的2-噁嗪-1-羧酰胺化合物是环氧合酶（CO）和脂氧合酶（LO）酶的抑制剂，并且在哺乳动物主体中作为镇痛和抗炎药物是有用的。这些2-噁嗪-1-羧酰胺化合物对于缓解人类手术或创伤康复患者的疼痛以及减轻人类主体中慢性疾病的症状，如类风湿性关节炎和骨关节炎，具有特殊价值。某些在C-3位未取代的2-噁嗪-1-羧酰胺化合物，但在羧酰胺氮上具有取代基，作为本发明的镇痛和抗炎药物的中间体是有用的。
• 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
  申请人：Pfizer Inc.

  公开号：US04721712A1

  公开（公告）日：1988-01-26

  Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and anti-inflammatory agents in mammalian subjects. These 2-oxindole-1-carboxamide compounds are of particular value for acute administration for ameliorating pain in human patients recovering from surgery or trauma, and also for chronic administration to human subjects for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis. Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having an acyl substituent on the carboxamide nitrogen atom, are useful as intermediates to the aforementioned analgesic and anti-inflammatory agents.

  某些在3位上具有酰基取代基，并且在羧酰胺氮原子上也有取代基的2-噁嗪-1-羧酰胺化合物是环氧合酶（CO）和脂氧合酶（LO）酶的抑制剂，并且在哺乳动物体内作为镇痛剂和抗炎剂具有用途。这些2-噁嗪-1-羧酰胺化合物对于急性给药用于缓解手术或创伤后人类患者的疼痛，以及对于慢性给药用于减轻慢性疾病症状，如类风湿性关节炎和骨关节炎的人类患者，具有特殊价值。某些在C-3位未取代的2-噁嗪-1-羧酰胺化合物，但在羧酰胺氮原子上具有酰基取代基，可作为上述镇痛剂和抗炎剂的中间体。
• Pyrazolo[1,5-c]quinazoline derivatives and related compounds
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04112098A1

  公开（公告）日：1978-09-05

  Compounds are provided having the structure ##STR1## wherein R.sup.1 is hydrogen, alkyl of 1 to 3 carbons, 1-(hydroxyimino)alkyl, alkanoylamino, amino, or ##STR2## wherein alkyl in the above groups contains 1 to 4 carbons; R.sup.2 is 1-(hydroxyimino)alkyl, alkanoylamino, amino, ##STR3## hydrogen, lower alkyl or phenyl (optionally substituted by R.sup.4) wherein alkyl in the above groups contains 1 to 4 carbons; R.sup.3 is hydrogen, lower alkyl, benzyl or phenyl (optionally substituted with R.sup.4), dialkylaminoalkyl, hydroxyalkyl, ##STR4## (wherein R.sup.6 is hydrogen or alkyl, and R.sup.7 is alkyl); with the proviso that R.sup.1 or R.sup.2 is 1-(hydroxyimino)alkyl, alkanoylamino or amino, when R.sup.3 is hydrogen, lower alkyl, benzyl or phenyl; and R.sup.4 and R.sup.5 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, hydroxy, halogen (Cl, Br and F), nitro and trifluoromethyl. The above compounds are useful as anti-allergy agents and antiinflammatory agents.

  提供具有结构##STR1##的化合物，其中R.sup.1是氢、1至3个碳的烷基、1-(羟亚胺)烷基、烷酰胺基、氨基，或##STR2##其中上述基团中的烷基含有1至4个碳；R.sup.2是1-(羟亚胺)烷基、烷酰胺基、氨基、##STR3##氢、较低烷基或苯基（可选地由R.sup.4取代）其中上述基团中的烷基含有1至4个碳；R.sup.3是氢、较低烷基、苄基或苯基（可选地由R.sup.4取代）、二烷基氨基烷基、羟基烷基、##STR4##（其中R.sup.6是氢或烷基，R.sup.7是烷基）；但要求当R.sup.3是氢、较低烷基、苄基或苯基时，R.sup.1或R.sup.2是1-(羟亚胺)烷基、烷酰胺基或氨基；R.sup.4和R.sup.5相同或不同，表示氢、较低烷基、较低烷氧基、烷酰氧基、苄氧基、羟基、卤素（Cl、Br和F）、硝基和三氟甲基。上述化合物可用作抗过敏剂和抗炎剂。
• Process for making 2-oxindole-1-carboxamides and intermediates therefor
  申请人：Pfizer Inc.

  公开号：US04652658A1

  公开（公告）日：1987-03-24

  Preparation of 2-oxindole-1-carboxamides by reaction of 2-oxindoles with chlorosulfonyl isocyanate to produce novel N-chlorosulfonyl-2-oxindole-1-carboxamides which are then hydrolyzed to 2-oxindole-1-carboxamides useful as intermediates for analgesic and antiinflammatory agents.

  通过将2-噁嗪与氯磺酰基异氰酸酯反应制备2-噁嗪-1-甲酰胺，从而产生新颖的N-氯磺酰基-2-噁嗪-1-甲酰胺，然后水解为有用的作为镇痛和抗炎药物中间体的2-噁嗪-1-甲酰胺。
• Intermediates for 1,3-disubstituted 2-oxindoles as analgesic and
  申请人：Pfizer Inc.

  公开号：US04658037A1

  公开（公告）日：1987-04-14

  Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and anti-inflammatory agents in mammalian subjects. Certain 2-oxindole compounds unsubstituted at the 1-position but having an acyl substituent at C-3 of the formula ##STR1## and the base salts thereof, wherein X is hydrogen, 5-fluoro, 5-chloro or 5-trifluoromethyl; Y is hydrogen, 6-fluoro, 6-chloro or 6-trifluoromethyl; and R.sup.1 is benzyl, furyl, thienyl or thienylmethyl; provided that when X and Y are both hydrogen, R.sup.1 is not benzyl are useful as intermediates to the aforementioned analgesic and anti-inflammatory agents.

  某些在3-位具有酰基取代基，并且在羧酰胺氮原子上也有取代基的2-噁嗪-1-羧酰胺化合物是环氧合酶（CO）和脂氧合酶（LO）酶的抑制剂，并且在哺乳动物体内作为镇痛剂和抗炎剂是有用的。某些在1-位未取代但在公式##STR1##的C-3处具有酰基取代基及其碱盐，其中X为氢、5-氟、5-氯或5-三氟甲基；Y为氢、6-氟、6-氯或6-三氟甲基；R.sup.1为苄基、呋喃基、噻吩基或噻吩甲基；但当X和Y均为氢时，R.sup.1不是苄基，作为前述镇痛剂和抗炎剂的中间体是有用的。