5-(8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazin-2-yl)pentanoic acid | 360061-51-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 5-(8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazin-2-yl)pentanoic acid
• CAS: 360061-51-4
• 化学式: C₁₂H₁₄N₆O₂
• 分子量: 274.282
• InChiKey: STNJLWSKNHYZFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.34
• 重原子数：
  20.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  120.44
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  4,5-Dichloro-3-methyl-1H-pyrazolo[3,4-c]pyridazine 在 盐酸 、 氨 作用下， 以 水 为溶剂， 反应 10.0h， 生成 5-(8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazin-2-yl)pentanoic acid
  参考文献：
  名称：

  2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent

  摘要：

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.

  DOI：

  10.1007/s00044-009-9290-9

文献信息

• 2-Substituted-8-methyl-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine as an anti-inflammatory agent
  作者：Ashish Kumar Tewari、Rashmi Dubey、Anil Mishra

  DOI：10.1007/s00044-009-9290-9

  日期：2011.1

  A series of 8-methyl-2-substituted-3,6-dihydroimidazo[4,5-c]pyrazolo[3,4-e]pyridazine compounds have been synthesized in the present investigation utilizing Philips condensation (Philips, J Chem Soc 2393-2399, 1928). The anti-inflammatory activity of the synthesized compounds was evaluated using a carrageenin rat model.