2-(2-hydroxyethyl)-1-oxo-3,7,8-trimethyl-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile | 166671-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(2-hydroxyethyl)-1-oxo-3,7,8-trimethyl-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile
• 英文别名: 2-(2-hydroxyethyl)-3,7,8-trimethyl-1-oxo-5H-pyrido[1,2-a]benzimidazole-4-carbonitrile
• CAS: 166671-27-8
• 化学式: C₁₇H₁₇N₃O₂
• 分子量: 295.341
• InChiKey: QBZRLVUAFPIIHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  76.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxyethyl)-1-oxo-3,7,8-trimethyl-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile 在 三氯氧磷 作用下， 反应 3.0h， 以90.3%的产率得到1-chloro-2-(2-chloroethyl)-3,7,8-trimethylpyrido<1,2-a>benzimidazole-4-carbonitrile
  参考文献：
  名称：

  Benzimidazole condensed ring system. IX. Potential antineoplastics. New synthesis of some pyrido[1,2-α]benzimidazoles and related derivative

  摘要：

  Some pyrido[1,2-a]benzimidazoles were prepared in order to investigate their in vitro antineoplastic and anti-HIV activities. Two compounds (9b, NSC 658526 and 15, NSC 664715) showed a variable degree of antineoplastic activity against some of the cell lines tested. Compound 9a (NSC 649900) exhibited a good in vitro antineoplastic activity with subpanel disease selectivity, particularly against most of the cell lines of leukemia and some cell lines from colon, melanoma and renal cancer panels.

  DOI：

  10.1016/0223-5234(96)88241-9
• 作为产物：
  描述：

  α-乙酰基-γ-丁内酯 、 (5,6-二甲基-1H-苯并咪唑-2-基)乙腈 在 乙酸铵 作用下， 反应 1.0h， 以61%的产率得到2-(2-hydroxyethyl)-1-oxo-3,7,8-trimethyl-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile
  参考文献：
  名称：

  Benzimidazole condensed ring system. IX. Potential antineoplastics. New synthesis of some pyrido[1,2-α]benzimidazoles and related derivative

  摘要：

  Some pyrido[1,2-a]benzimidazoles were prepared in order to investigate their in vitro antineoplastic and anti-HIV activities. Two compounds (9b, NSC 658526 and 15, NSC 664715) showed a variable degree of antineoplastic activity against some of the cell lines tested. Compound 9a (NSC 649900) exhibited a good in vitro antineoplastic activity with subpanel disease selectivity, particularly against most of the cell lines of leukemia and some cell lines from colon, melanoma and renal cancer panels.

  DOI：

  10.1016/0223-5234(96)88241-9

文献信息

• Benzimidazole condensed ring system. IX. Potential antineoplastics. New synthesis of some pyrido[1,2-α]benzimidazoles and related derivative
  作者：E Badawey、T Kappe

  DOI：10.1016/0223-5234(96)88241-9

  日期：1995.1

  Some pyrido[1,2-a]benzimidazoles were prepared in order to investigate their in vitro antineoplastic and anti-HIV activities. Two compounds (9b, NSC 658526 and 15, NSC 664715) showed a variable degree of antineoplastic activity against some of the cell lines tested. Compound 9a (NSC 649900) exhibited a good in vitro antineoplastic activity with subpanel disease selectivity, particularly against most of the cell lines of leukemia and some cell lines from colon, melanoma and renal cancer panels.