tert-butyl (2-(2-(2-(4-aminobenzamido)ethoxy)ethoxy)ethyl)carbamate | 796702-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (2-(2-(2-(4-aminobenzamido)ethoxy)ethoxy)ethyl)carbamate
• 英文别名: tert-butyl N-[2-[2-[2-[(4-aminobenzoyl)amino]ethoxy]ethoxy]ethyl]carbamate
• CAS: 796702-45-9
• 化学式: C₁₈H₂₉N₃O₅
• 分子量: 367.445
• InChiKey: DJJVMJXIBDMYEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl (2-(2-(2-(4-aminobenzamido)ethoxy)ethoxy)ethyl)carbamate 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 N-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethyl}-4-[4-isopropylamino-6-(3-methoxy-benzylamino)-[1,3,5]triazin-2-ylamino]-benzamide
  参考文献：
  名称：

  Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening

  摘要：

  An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.

  DOI：

  10.1021/ja035334d
• 作为产物：
  描述：

  1,8-二氨基-3,6-二氧杂辛烷 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 生成 tert-butyl (2-(2-(2-(4-aminobenzamido)ethoxy)ethoxy)ethyl)carbamate
  参考文献：
  名称：

  Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening

  摘要：

  An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.

  DOI：

  10.1021/ja035334d

文献信息

• [EN] MOLECULES AND METHODS RELATED TO TREATMENT OF UNCONTROLLED CELLULAR PROLIFERATION<br/>[FR] MOLÉCULES ET PROCÉDÉS SE RAPPORTANT AU TRAITEMENT DE LA PROLIFÉRATION INCONTRÔLÉE DE CELLULES
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2021022076A1

  公开（公告）日：2021-02-04

  The present disclosure relates to chemical compounds that modulate cellular proliferation for the treatment of uncontrolled cellular proliferation disorders (such as cancer), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及调节细胞增殖以治疗不受控制的细胞增殖疾病（如癌症）的化合物，含有这种化合物的药物组合物，以及它们在治疗中的应用。本摘要旨在作为在特定领域搜索的扫描工具，并不意味着对本发明的限制。
• NOVEL CROSSLINKED ALGINIC ACID
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：EP3808783A1

  公开（公告）日：2021-04-21

  The present invention provides alginic acid derivatives represented by formula (I) and formula (II), and a novel crosslinked alginic acid obtained by carrying out a Huisgen reaction using an alginic acid derivative of formula (I) and an alginic acid derivative of formula (II). There are thereby provided novel alginic acid derivatives and a novel crosslinked alginic acid.

  本发明提供了由式（I）和式（II）表示的海藻酸衍生物，以及通过使用式（I）的海藻酸衍生物和式（II）的海藻酸衍生物进行惠斯根反应而获得的新型交联海藻酸。由此提供了新型海藻酸衍生物和新型交联海藻酸。
• [EN] FACILITATED FORWARD CHEMICAL GENETICS USING TAGGED TRIAZINE LIBRARY<br/>[FR] GENETIQUE CHIMIQUE FACILITEE VERS L'AVANT UTILISANT UNE BANQUE DE TRIAZINES MARQUEES
  申请人：UNIV NEW YORK

  公开号：WO2004099106A3

  公开（公告）日：2005-02-24
• [EN] CHEMICALLY CROSSLINKED ALGINATE GEL FIBER<br/>[FR] FIBRES DE GEL D'ACIDE ALGINIQUE CHIMIQUEMENT RÉTICULÉ<br/>[JA] 化学架橋アルギン酸ゲルファイバ
  申请人：MOCHIDA PHARM CO LTD

  公开号：WO2021125279A1

  公开（公告）日：2021-06-24

  さらなる抗体の生産方法が求められていた。抗体産生細胞（例えば、抗体産生ＣＨＯ細胞）をコア層に含ませた抗体生産用の化学架橋アルギン酸ゲルファイバ、及び当該アルギン酸ゲルファイバを用いる抗体の製造方法。
• Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening
  作者：Sonya M. Khersonsky、Da-Woon Jung、Tae-Wook Kang、Daniel P. Walsh、Ho-Sang Moon、Hakryul Jo、Eric M. Jacobson、Vivekananda Shetty、Thomas A. Neubert、Young-Tae Chang

  DOI：10.1021/ja035334d

  日期：2003.10.1

  An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.