1,10-decanediol bis-succinate | 35415-12-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,10-decanediol bis-succinate
• 英文别名: 4-[10-(3-Carboxypropanoyloxy)decoxy]-4-oxobutanoic acid
• CAS: 35415-12-4
• 化学式: C₁₈H₃₀O₈
• 分子量: 374.431
• InChiKey: URJKAOUNWDOHSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 1,10-decanediol bis-succinate 、 保护胸苷 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 生成 Succinic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 10-[3-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-propionyloxy]-decyl ester
  参考文献：
  名称：

  Fiber-Optic DNA Sensor for Fluorometric Nucleic Acid Determination

  摘要：

  Single-stranded deoxyribonucleic acid (ssDNA) thymidylic acid icosanucleotides (dT(20)) were synthesized on the surfaces of derivatized quartz optical fibers to create an optical DNA biosensor. The synthesis made use of an automated solid-phase synthesizer and phosphoramidite synthons, The covalently immobilized oligomers were found to hybridize with complementary ssDNA (cDNA) or ssRNA (cRNA) from solution, and the device was regenerable for multiple cycles of application. Hybridization on optical fibers was detected by the use of the fluorescent DNA stain ethidium bromide (EB). The procedure used hybridization assay techniques and provided a detection limit of 86 ng . mL(-1) cDNA and a sensitivity of 200% fluorescence intensity increase per 100 ng . mL(-1) of cDNA, with one cycle of hybridization analysis requiring 45 min, The sensor has been observed to be regenerable (minimum of five cycles) and to sustain full activity after prolonged storage times (1 year), harsh washing conditions (sonication), and sterilization (autoclaving). The extent of hybridization between the immobilized and complementary nucleic acid strands was determined by UV absorbance thermal denaturation studies wherein ah 20 bases on each strand of the nucleic acid were found to be involved in duplex formation.

  DOI：

  10.1021/ac00111a022
• 作为产物：
  描述：

  丁二酸酐 、 1,10-癸二醇 在 4-二甲氨基吡啶 作用下， 生成 1,10-decanediol bis-succinate
  参考文献：
  名称：

  Fiber-Optic DNA Sensor for Fluorometric Nucleic Acid Determination

  摘要：

  Single-stranded deoxyribonucleic acid (ssDNA) thymidylic acid icosanucleotides (dT(20)) were synthesized on the surfaces of derivatized quartz optical fibers to create an optical DNA biosensor. The synthesis made use of an automated solid-phase synthesizer and phosphoramidite synthons, The covalently immobilized oligomers were found to hybridize with complementary ssDNA (cDNA) or ssRNA (cRNA) from solution, and the device was regenerable for multiple cycles of application. Hybridization on optical fibers was detected by the use of the fluorescent DNA stain ethidium bromide (EB). The procedure used hybridization assay techniques and provided a detection limit of 86 ng . mL(-1) cDNA and a sensitivity of 200% fluorescence intensity increase per 100 ng . mL(-1) of cDNA, with one cycle of hybridization analysis requiring 45 min, The sensor has been observed to be regenerable (minimum of five cycles) and to sustain full activity after prolonged storage times (1 year), harsh washing conditions (sonication), and sterilization (autoclaving). The extent of hybridization between the immobilized and complementary nucleic acid strands was determined by UV absorbance thermal denaturation studies wherein ah 20 bases on each strand of the nucleic acid were found to be involved in duplex formation.

  DOI：

  10.1021/ac00111a022

文献信息

• Synthesis of Macrocyclic Dilactones through Lipases
  作者：Mª Pilar Bosch、Angel Guerrero

  DOI：10.1055/s-2005-917099

  日期：——

  We report herein a selective and efficient method to prepare macrocyclic dilactones in good yields from diols and succinic anhydride through a biocatalytic condensation reaction.

  我们在此报告了一种通过生物催化缩合反应从二醇和琥珀酸酐以良好收率制备大环双内酯的选择性和有效方法。
• Arnold, Lubos; Tocik, Zdenek; Bradkova, Eliska, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 2, p. 523 - 532
  作者：Arnold, Lubos、Tocik, Zdenek、Bradkova, Eliska、Hostomsky, Zdenek、Paces, Vaclav、Smrt, Jiri

  DOI：——

  日期：——
• ARNOLD, LUBOS;TOCIK, ZDENEK;BRADKOVA, ELISKA;HOSTOMSKY, ZDENEK;PACES, VAC+, COLLECT. CZECHOSL. CHEM. COMMUN., 54,(1989) N, C. 523-532
  作者：ARNOLD, LUBOS、TOCIK, ZDENEK、BRADKOVA, ELISKA、HOSTOMSKY, ZDENEK、PACES, VAC+

  DOI：——

  日期：——
• Fiber-Optic DNA Sensor for Fluorometric Nucleic Acid Determination
  作者：Paul A. E. Piunno、Ulrich J. Krull、Robert H. E. Hudson、Masad J. Damha、Huguette. Cohen

  DOI：10.1021/ac00111a022

  日期：1995.8.1

  Single-stranded deoxyribonucleic acid (ssDNA) thymidylic acid icosanucleotides (dT(20)) were synthesized on the surfaces of derivatized quartz optical fibers to create an optical DNA biosensor. The synthesis made use of an automated solid-phase synthesizer and phosphoramidite synthons, The covalently immobilized oligomers were found to hybridize with complementary ssDNA (cDNA) or ssRNA (cRNA) from solution, and the device was regenerable for multiple cycles of application. Hybridization on optical fibers was detected by the use of the fluorescent DNA stain ethidium bromide (EB). The procedure used hybridization assay techniques and provided a detection limit of 86 ng . mL(-1) cDNA and a sensitivity of 200% fluorescence intensity increase per 100 ng . mL(-1) of cDNA, with one cycle of hybridization analysis requiring 45 min, The sensor has been observed to be regenerable (minimum of five cycles) and to sustain full activity after prolonged storage times (1 year), harsh washing conditions (sonication), and sterilization (autoclaving). The extent of hybridization between the immobilized and complementary nucleic acid strands was determined by UV absorbance thermal denaturation studies wherein ah 20 bases on each strand of the nucleic acid were found to be involved in duplex formation.