5-(6-氨基嘌呤-9-基)环戊-3-烯-1,2-二醇 | 112318-09-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 中文名称: 5-(6-氨基嘌呤-9-基)环戊-3-烯-1,2-二醇
• 英文名称: 5-(6-Aminopurin-9-yl)cyclopent-3-ene-1,2-diol
• CAS: 112318-09-9
• 化学式: C₁₀H₁₁N₅O₂
• 分子量: 233.23
• InChiKey: RQPALADHFYHEHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• HPV particles and uses thereof
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：US10179168B2

  公开（公告）日：2019-01-15

  The invention relates to modified HPV particles that can be used therapeutically. Modified HPV particles may be used to deliver therapeutic agents, including siRNA molecules. Modified HPV particles may be used for the treatment of diseases or conditions of mucosal tissue, including HPV (human papilloma virus) infection and HPV-related tumors.

  本发明涉及可用于治疗的改良 HPV 颗粒。经修饰的 HPV 颗粒可用于递送治疗剂，包括 siRNA 分子。经修饰的 HPV 颗粒可用于治疗粘膜组织的疾病或病症，包括 HPV（人乳头瘤病毒）感染和 HPV 相关肿瘤。
• Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells
  申请人：Aura Biosciences, Inc.

  公开号：US10300150B2

  公开（公告）日：2019-05-28

  The invention relates to methods for producing papilloma-derived nanosphere particles that contain therapeutic, diagnostic, or other agents. The invention also provides nanosphere particle preparations that are useful for selectively delivering therapeutic, diagnostic, and/or other agents to cancer cells of subjects without eliciting a serotype-specific immunogenic response in the subjects.

  本发明涉及生产含有治疗、诊断或其他制剂的乳头状瘤衍生纳米球颗粒的方法。本发明还提供了纳米球颗粒制剂，可用于选择性地向受试者的癌细胞递送治疗、诊断和/或其他制剂，而不会在受试者体内引起血清型特异性免疫原反应。
• HPV PARTICLES AND USES THEREOF
  申请人：INSERM - Institut National de la Santé et de la Recherche Médicale

  公开号：EP2419143A1

  公开（公告）日：2012-02-22
• Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For The Treatment of Alopecia
  申请人：De Los Pinos Elisabet

  公开号：US20130012566A1

  公开（公告）日：2013-01-10

  This invention relates to a transdermal delivery system for treating skin related diseases employing papilloma-derived protein nanoparticles to deliver drugs to the keratinocytes and basal membrane cells for the treatment of alopecia. The current invention presents an effective method for delivering small molecule nucleic acids to the epidermal cells.
• VIRION-DERIVED NANOSPHERES FOR SELECTIVE DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS TO CANCER CELLS
  申请人：Aura Biosciences, Inc.

  公开号：US20140377170A1

  公开（公告）日：2014-12-25

  The invention relates to methods for producing papilloma-derived nanosphere particles that contain therapeutic, diagnostic, or other agents. The invention also provides nanosphere particle preparations that are useful for selectively delivering therapeutic, diagnostic, and/or other agents to cancer cells of subjects without eliciting a serotype-specific immunogenic response in the subjects.