(4-((6-bromohexyl)oxy)phenyl)(phenyl)methanone | 74992-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-((6-bromohexyl)oxy)phenyl)(phenyl)methanone
• 英文别名: 4-[(6-bromohexyl)oxy]benzophenone；[4-(6-bromohexoxy)phenyl]-phenylmethanone
• CAS: 74992-91-9
• 化学式: C₁₉H₂₁BrO₂
• 分子量: 361.279
• InChiKey: QRPSUORVYRUDCM-UHFFFAOYSA-N

物化性质

• 熔点：
  62-64 °C(Solv: hexane (110-54-3); toluene (108-88-3))
• 沸点：
  474.8±30.0 °C(Predicted)
• 密度：
  1.257±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-((6-bromohexyl)oxy)phenyl)(phenyl)methanone 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以85%的产率得到4-(6-iodohexoxy)benzophenone
  参考文献：
  名称：

  [EN] UV CURED BENZOPHENONE TERMINATED QUATERNARY AMMONIUM ANTIMICROBIALS FOR SURFACES
  [FR] REVÊTEMENTS ANTIMICROBIENS À BASE D'AMMONIUM QUATERNAIRE À TERMINAISON BENZOPHÉNONE DURCIS PAR UV POUR SURFACES

  摘要：

  该发明涉及苯酮端四元铵化合物，制备苯酮端四元铵化合物的方法，含有该四元铵化合物的环保抗菌配方，以及它们作为耐用抗菌表面涂层的用途。

  公开号：

  WO2014089680A1
• 作为产物：
  描述：

  4-甲氧基二苯甲酮 在 sodium hydroxide 、 四丁基溴化铵 、 氢溴酸 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 41.0h， 生成 (4-((6-bromohexyl)oxy)phenyl)(phenyl)methanone
  参考文献：
  名称：

  Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

  摘要：

  New orally active non-terpenoic inhibitors of human 2,3-oxidosqualene cyclase (hOSC) are reported. The starting point for the optimization process was a set of compounds derived from a fungicide project, which in addition to showing high affinity for OSC from Candida albicans showed also high affinity for human OSC. Common structural elements of these inhibitors are an amine residue and an electrophilic carbonyl C atom embedded in a benzophenone system, which are at a distance of about 10.7 Angstrom. Considering that the keto moiety is in a potentially labile position, modifications of the substitution pattern at the benzophenone as well as annelated heteroaryl systems were explored. Our approach combined testing of the compounds first for increased binding affinity and for increased stability in vitro. Most promising compounds were then evaluated for their efficacy in lowering plasma total cholesterol (TC) and plasma low-density lipoprotein cholesterol (LDL-C) in hyperlipidemic hamsters. In this respect, the most promising compounds are the benzophenone derivative 1.fumarate and the benzo[d]-isothiazol 24.fumarate, which lowered TC by 40% and 33%, respectively.

  DOI：

  10.1021/jm021120f

文献信息

• Synthesis, structures and properties of self-assembling quaternary ammonium dansyl fluorescent tags for porous and non-porous surfaces
  作者：Lukasz M. Porosa、Kamlesh B. Mistry、Amanda Mocella、Hellen Deng、Shayan Hamzehi、Alex Caschera、Alan J. Lough、Gideon Wolfaardt、Daniel A. Foucher

  DOI：10.1039/c3tb21633k

  日期：——

  Surface grafted silane, phosphate and benzophenone dansyl molecules.

  表面接枝的偶氮基苯基磺酰胺分子。
• Magnetic Field Effects on the Dynamics of Biradicals Generated from Benzophenone and Diphenylamine Bifunctional Chain Molecules
  作者：Yoshifumi Tanimoto、Natsuo Okada、Shinji Takamatsu、Michiya Itoh

  DOI：10.1246/bcsj.63.1342

  日期：1990.5

  The magnetic field effects (MFE) on the lifetimes of triplet biradicals generated from the intramolecular photoreaction of bifunctional chain molecules, α-(4-benzoylphenoxy)-ω-[4-(phenylamino)phenoxy]alkanes (BP–O–n–O–DPA, n=2–16) were studied by laser flash photolysis. MFE on the biradical lifetimes are strongly affected by magnetic field, chain length, and solvent. The effects are interpreted in

  双功能链分子α-(4-苯甲酰基苯氧基)-ω-[4-(苯基氨基)苯氧基]烷烃(BP-O-n-O)的分子内光反应产生的三线态双自由基寿命的磁场效应(MFE) –DPA, n=2–16) 通过激光闪光光解进行研究。双自由基寿命的 MFE 受磁场、链长和溶剂的强烈影响。根据高频松弛机制来解释效果。在n=2和4的双自由基中观察到由于T--S能级交叉导致的寿命变化。当n≥6时，双自由基发生单线态和三线态简并。
• [EN] ANTIMICROBIAL COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ANTIMICROBIENS ET LEURS UTILISATIONS
  申请人：JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENT RESEARCH

  公开号：WO2021199082A1

  公开（公告）日：2021-10-07

  The present disclosure relates to compounds of Formula I, II, III or its stereoisomers, polymorphs, solvates, hydrates, intermediates, and pharmaceutically active derivatives thereof. The present disclosure relates to a process of preparing the compounds of Formula I, II or III. The present disclosure further relates to an antimicrobial composition comprising the compounds of Formula I, II or III and method of forming an antimicrobial composition thereof. The present disclosure also relates to a method of treating a microbial infection.

  本公开涉及化合物的公式I、II、III或其立体异构体、多晶形态、溶剂合物、水合物、中间体以及其药用活性衍生物。本公开涉及制备公式I、II或III化合物的方法。本公开还涉及包含公式I、II或III化合物的抗微生物组合物及其形成抗微生物组合物的方法。本公开还涉及治疗微生物感染的方法。
• 半乳糖苷-四苯乙烯类化合物及其制备方法以及其作为药物载体的应用
  申请人：河南师范大学

  公开号：CN110627846B

  公开（公告）日：2022-11-29

  本发明属于化学技术领域，具体涉及一种半乳糖苷‑四苯乙烯类化合物及其制备方法，以及其作为药物载体的应用。所述半乳糖苷‑四苯乙烯类化合物以TPE为疏水实体，以半乳糖为亲水实体，通过三氮唑结合而成，利用疏水实体四苯乙烯(TPE)的聚集诱导发光效应可构建多功能体系的成像，可实现可视化的药物转运，利用亲水实体半乳糖的靶向作用，可实现药物的靶向递送，同时，该半乳糖苷‑四苯乙烯类化合物可通过透析法方便地自组装成均匀而坚固的囊泡，自组装形成的囊泡还具有良好的分散性能和良好的载药性能，可以使抗癌药物具有更加优良的药代动力学特性，在药物控释和肿瘤靶向治疗方面具有潜在的应用前景。
• PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF MAKING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF USING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, AND METHODS OF MAKING ARTICLES CONTAINING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS
  申请人：THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：US20140242866A1

  公开（公告）日：2014-08-28

  Embodiments of the present disclosure, in one aspect, relate to polymer compositions, methods of making polymer compositions, structures having the polymer composition covalently bonded to the surface of the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, materials, methods of attaching materials, and the like.

  本公告的实施例在一个方面涉及聚合物组合物，制备聚合物组合物的方法，具有聚合物组合物共价键结合到结构表面上的结构，将聚合物附着到结构表面的方法，减少在结构上形成的微生物数量的方法，材料，附着材料的方法等。