Tert-butyl-[[2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-5-yl]methoxy]-dimethylsilane | 445460-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Tert-butyl-[[2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-5-yl]methoxy]-dimethylsilane
• 英文别名: tert-butyl-[[2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-5-yl]methoxy]-dimethylsilane
• CAS: 445460-42-4
• 化学式: C₁₉H₃₂O₄Si
• 分子量: 352.546
• InChiKey: KAXSPGKMRDKVBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.77
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tert-butyl-[[2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-5-yl]methoxy]-dimethylsilane 在 二异丁基氢化铝 作用下， 生成 2-[[Tert-butyl(dimethyl)silyl]oxymethyl]-3-[(4-methoxyphenyl)methoxy]-2-methylpropan-1-ol
  参考文献：
  名称：

  Synthesis and structure of 2-aryl-5,5-disubstituted-1,3-dioxanes and conversion into chiral (1,1,1-trishydroxymethyl) methane derivatives

  摘要：

  Pentaerythritol, (1,1,1-trishydroxymethyl)methyl methane and ( 1, 1,1-trishydroxymethyl)nitro methane are converted into 2-aryl-5.5-bis(hydroxymethyl), 2-aryl-5-hydroxymethyl-5-methyl- or 2-aryl-5-hydroxymethyl-5-nitro-1,3-dioxanes and a range of derivatives. X-Ray and NMR analysis establishes that the latter is obtained as a single diastereomer whose structure is unambiguously determined. These materials can be elaborated to chiral derivatives of the starting (1.1.1-trishydroxymethyl) methanes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00176-4
• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 在 camphor-10-sulfonic acid 作用下， 以 乙腈 为溶剂， 生成 Tert-butyl-[[2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-5-yl]methoxy]-dimethylsilane
  参考文献：
  名称：

  Synthesis and structure of 2-aryl-5,5-disubstituted-1,3-dioxanes and conversion into chiral (1,1,1-trishydroxymethyl) methane derivatives

  摘要：

  Pentaerythritol, (1,1,1-trishydroxymethyl)methyl methane and ( 1, 1,1-trishydroxymethyl)nitro methane are converted into 2-aryl-5.5-bis(hydroxymethyl), 2-aryl-5-hydroxymethyl-5-methyl- or 2-aryl-5-hydroxymethyl-5-nitro-1,3-dioxanes and a range of derivatives. X-Ray and NMR analysis establishes that the latter is obtained as a single diastereomer whose structure is unambiguously determined. These materials can be elaborated to chiral derivatives of the starting (1.1.1-trishydroxymethyl) methanes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00176-4

文献信息

• Synthesis and structure of 2-aryl-5,5-disubstituted-1,3-dioxanes and conversion into chiral (1,1,1-trishydroxymethyl) methane derivatives
  作者：John M Gardiner、Paul Mather、Ramy Morjan、Robin G Pritchard、John E Warren、Malcolm L Cooper、Abd El-Rahman S Ferwanah、Omar S Abu-Tiem

  DOI：10.1016/s0040-4039(02)00176-4

  日期：2002.3

  Pentaerythritol, (1,1,1-trishydroxymethyl)methyl methane and ( 1, 1,1-trishydroxymethyl)nitro methane are converted into 2-aryl-5.5-bis(hydroxymethyl), 2-aryl-5-hydroxymethyl-5-methyl- or 2-aryl-5-hydroxymethyl-5-nitro-1,3-dioxanes and a range of derivatives. X-Ray and NMR analysis establishes that the latter is obtained as a single diastereomer whose structure is unambiguously determined. These materials can be elaborated to chiral derivatives of the starting (1.1.1-trishydroxymethyl) methanes. (C) 2002 Elsevier Science Ltd. All rights reserved.