4-Benzoyl-1,5-diphenyl-pyrazol | 85302-11-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Benzoyl-1,5-diphenyl-pyrazol
• 英文别名: 4-benzoyl-1,5-diphenylpyrazole；(1,5-diphenyl-1H-pyrazol-4-yl)-phenyl-methanone；(1,5-diphenyl-1H-pyrazol-4-yl)-phenyl ketone；(1,5-Diphenyl-1H-pyrazol-4-yl)-phenyl-keton；-Benzoyl-1,5-diphenyl-pyrazol；4-Benzoyl-1.5-diphenylpyrazol；(1,5-Diphenylpyrazol-4-yl)-phenylmethanone
• CAS: 85302-11-0
• 化学式: C₂₂H₁₆N₂O
• 分子量: 324.382
• InChiKey: COWSLJWFSRYRBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Benzoyl-1,5-diphenyl-pyrazol 在 sodium tetrahydroborate 、 氯化亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 48.0h， 生成 1-[(1,5-Diphenyl-1H-pyrazol-4-yl)-phenyl-methyl]-1H-[1,2,4]triazole
  参考文献：
  名称：

  Synthesis and biological evaluation of [α-(1,5-disubstituted 1H-pyrazol-4-yl)benzyl]azoles, analogues of bifonazole

  摘要：

  A series of pyrazole analogues of bifonazole, an antifungal drug used in clinical practice, 2a-h and 4a-b were synthesized and tested in vitro against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, with no significant results. Imidazoles 2a-h were also tested in vivo for antiarrhythmic and antihypertensive activities; two of these compounds showed moderate activity against ventricular fibrillation caused by aconitine in rats. The above compounds were prepared by reaction of phenyl[5 substituted 1-phenyl (or 1-methyl)-1H-pyrazol-4-yl]methanols with N,N'-carbonyldiimidazole (2a-h) or of the respective chloro derivatives with 1H-1,2,4-triazole (4a-h). (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00036-1
• 作为产物：
  描述：

  4-benzoyl-5-phenyl-furan-2,3-dione 以 苯 为溶剂， 反应 1.0h， 生成 4-Benzoyl-1,5-diphenyl-pyrazol
  参考文献：
  名称：

  Reaktionen mit cyclischen Oxalylverbindungen, XXIV. Zur Reaktion von 4-Benzoyl-5-phenyl-furan-2,3-dion mit Phenylhydrazonen bzw. Phenylhydrazin

  摘要：

  DOI：

  10.1007/bf00809443

文献信息

• Synthesis of 4-Aroyl-5-arylpyrazoles and 4-Aroyl-3-arylpyrazoles via the Reaction of Enaminodiketones with Substituted Hydrazines
  作者：Tominari Choshi、Rika Kotouge、Takashi Nishiyama、Kanako Ono、Noriyuki Hatae、Satoshi Hibino

  DOI：10.3987/com-19-14096

  日期：——

  symmetrical enaminodiketones 8–14 with substituted hydrazines. When using alkylhydrazines, if the substituent size of the alkyl group is small, it is possible to selectively synthesize 1-substituted 4-aroyl-5arylpyrazoles and their regioisomers, 1-substituted 4-aroyl-3-arylpyrazoles, by choosing the solvent (EtOH or toluene). When they react with bulky substituted hydrazines (e.g., cyclohexyl, phenyl, or pyridyl)

  吡唑是一种五元杂环化合物，是医学和药理学领域重要的杂环化合物之一。在这里，我们展示了对称烯氨基二酮 8-14 与取代肼的反应性。使用烷基肼时，如果烷基的取代基尺寸较小，则可以通过选择溶剂（EtOH或甲苯）。当它们与大体积取代的肼（例如环己基、苯基或吡啶基）反应时，仅选择性地获得1-取代的4-芳酰基5-芳基吡唑。
• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。
• v. Auwers; Mauss, Journal fur praktische Chemie (Leipzig 1954), 1927, vol. <2> 117, p. 331
  作者：v. Auwers、Mauss

  DOI：——

  日期：——
• Schenone, Pietro; Mosti, Luisa; Menozzi, Giulia, Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 1355 - 1361
  作者：Schenone, Pietro、Mosti, Luisa、Menozzi, Giulia

  DOI：——

  日期：——
• SCHENONE, P.;MOSTI, L.;MENOZZI, G., J. HETEROCYCL. CHEM., 1982, 19, N 6, 1355-1361
  作者：SCHENONE, P.、MOSTI, L.、MENOZZI, G.

  DOI：——

  日期：——