(+/-)-2-Heptyl-bernsteinsaeure | 3507-63-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (+/-)-2-Heptyl-bernsteinsaeure
• 英文别名: n-Heptyl-bernsteinsaeure；heptyl-succinic acid；Heptyl-bernsteinsaeure；2-Heptylbutanedioic acid
• CAS: 3507-63-9
• 化学式: C₁₁H₂₀O₄
• 分子量: 216.277
• InChiKey: XEMGZCWREZSLND-UHFFFAOYSA-N

物化性质

• 熔点：
  90-91 °C
• 沸点：
  327.8±15.0 °C(Predicted)
• 密度：
  1.082±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  diethyl 2-heptylidenebutanedioate 在 sodium hydroxide 、 palladium on activated charcoal 、 乙醇 作用下， 生成 (+/-)-2-Heptyl-bernsteinsaeure
  参考文献：
  名称：

  Overberger; Roberts, Journal of the American Chemical Society, 1949, vol. 71, p. 3621

  摘要：

  DOI：

文献信息

• Conjugated peptide nucleic acids having enhanced cellular uptake
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US20020188101A1

  公开（公告）日：2002-12-12

  Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.

  连接到亲脂基团的肽核酸并包含在脂质体中，表现出增强的细胞摄取和分布。引入氨基酸侧链到肽核酸骨架中，也可以增加肽核酸的细胞摄取和分布。本发明提供了调节细胞摄取的方法和治疗动物的方法。本发明的肽核酸包括天然核苷酸和连接到聚酰胺骨架上的非天然核苷酸。
• A (meth)acrylic molding material and a production process thereof
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0749990A1

  公开（公告）日：1996-12-27

  The present invention provides a (meth)acrylic molding material comprising (A) a (meth)acrylic polymer obtained by polymerization of monomer components essentially containing a monomer having (a) carboxyl group(s) and an alkyl (meth)acrylate monomer, and (B) one or more kinds of monomers containing a vinyl group, wherein 30 - 600 parts by weight of aluminum hydroxide and 0.01 - 10 parts by weight of a succinic acid derivative are added for 100 parts by weight of the total of said polymer (A) and monomer (B). The (meth)acrylic molding material is thickened by aluminum hydroxide and the thickening behavior is controlled by the succinic acid derivative to prevent the viscosity from increasing with time, accordingly, the (meth)acrylic molding material shows good workability.

  本发明提供了一种(甲基)丙烯酸模塑材料，该材料包含(A)一种(甲基)丙烯酸聚合体，该聚合体是由基本上包含有(a)个羧基的单体和烷基(甲基)丙烯酸酯单体的单体组分聚合而成，以及(B)一种或多种包含乙烯基的单体，其中按所述聚合体(A)和单体(B)的总重量计算，每 100 重量份添加 30 - 600 重量份的氢氧化铝和 0.01 - 10 重量份的琥珀酸衍生物。氢氧化铝使（甲基）丙烯酸模塑材料增稠，琥珀酸衍生物控制增稠行为，防止粘度随时间增加，因此，（甲基）丙烯酸模塑材料显示出良好的可加工性。
• (METH)ACRYLIC SYRUP, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING MOLDING MATERIAL CONTAINING (METH)ACRYLIC SYRUP
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0796873A1

  公开（公告）日：1997-09-24

  The present invention provides (meth)acryl syrup which shows excellent storage stability as a molding material, and also provides a method of manufacturing the (meth)acryl syrup in a shorter period of time compared with the conventional method, and a molding material which permits a molded article having excellent heat-resistance, solvent-resistance, weathering resistance, and water-resistance, etc., to be manufactured. The (meth)acryl syrup is manufactured, for example, by polymerizing a monomer component including (meth)acrylic ester and a vinyl monomer having a carboxyl group in a presence of a thiol compound, and subsequently processing the reaction mixture with maleic anhydride and a basic compound. The molding material includes the (meth)acryl syrup, and may also include a thickening agent, derivatives of succinic acid, a reinforcing material, etc.

  本发明提供了(甲基)丙烯酸糖浆，它作为模塑材料具有优异的储存稳定性，还提供了一种与传统方法相比可以在更短时间内制造(甲基)丙烯酸糖浆的方法，以及一种可以制造出具有优异耐热性、耐溶剂性、耐候性和耐水性等特性的模塑制品的模塑材料。例如，(甲基)丙烯酸糖浆的制造方法是：在硫醇化合物存在的情况下，聚合单体成分，包括(甲基)丙烯酸酯和具有羧基的乙烯基单体，然后用马来酸酐和碱性化合物处理反应混合物。成型材料包括（甲基）丙烯酸糖浆，还可以包括增稠剂、琥珀酸衍生物、增强材料等。
• COMPOSITION FOR HYDROPHILIC CURED PRODUCT
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3081578A1

  公开（公告）日：2016-10-19

  Objects of the present invention are to provide a composition which can easily give cured products enriched with hydrophilic groups at the surface, and a composition which can give cured products while ensuring that the surface is enriched with hydrophilic groups which are hardly concentrated at the surface by conventional methods; to provide cured products obtained from such compositions; to provide a composition which is suited for producing cured products having high and long-lasting hydrophilicity and also having high surface smoothness; and to provide a cured product obtained from the composition. A monolayer film is fabricated which includes a crosslinked resin obtained by polymerizing a composition including a compound (I) having at least one hydrophilic group selected from anionic hydrophilic groups, cationic hydrophilic groups and hydroxyl groups, and at least one functional group with a polymerizable carbon-carbon double bond (wherein the number of the functional groups with a polymerizable carbon-carbon double bond is one when the hydrophilic group is a hydroxyl-containing group); a compound (II) having two or more functional groups with a polymerizable carbon-carbon double bond (wherein the compound may have a hydroxyl group but is free from anionic hydrophilic groups and cationic hydrophilic groups); and at least one compound selected from a surfactant (III) having a hydrophilic moiety including an anionic hydrophilic group, a cationic hydrophilic group or two or more hydroxyl groups, and a hydrophobic moiety including an organic residue, and a compound (IV) having a siloxane bond and a molecular weight of 200 to 1,000,000 (wherein the surfactant (III) and the compound (IV) have no polymerizable carbon-carbon double bonds). The monolayer film has a gradient of hydrophilic group concentration (Sa/Da) of not less than 1.1 wherein Sa is the surface concentration of at least one type of hydrophilic groups selected from anionic hydrophilic groups, cationic hydrophilic groups and hydroxyl groups, and Da is the deep concentration of the hydrophilic groups at 1/2 of the thickness of the monolayer film.

  本发明的目的是提供一种组合物，该组合物可以很容易地得到表面富含亲水基团的固化产品，以及一种组合物，该组合物可以在得到固化产品的同时确保表面富含亲水基团，而通过传统方法，亲水基团很难集中在表面上；提供由这种组合物得到的固化产品；提供一种组合物，该组合物适合生产具有高且持久亲水性的固化产品，同时还具有高表面光滑度；以及提供由该组合物得到的固化产品。本发明制备了一种单层膜，该单层膜包括通过聚合一种组合物而获得的交联树脂，该组合物包括一种化合物 (I)，该化合物具有至少一个亲水基团，该亲水基团选自阴离子亲水基团、阳离子亲水基团和羟基，以及至少一个具有可聚合碳碳双键的官能团（其中当亲水基团为含羟基基团时，具有可聚合碳碳双键的官能团的数目为一个）；具有两个或两个以上具有可聚合碳碳双键的官能团的化合物 (II)（其中该化合物可具有羟基，但不含阴离子亲水基团和阳离子亲水基团）；以及至少一种选自表面活性剂（III）的化合物，该表面活性剂具有包括阴离子亲水基团、阳离子亲水基团或两个或多个羟基在内的亲水分子，以及包括有机残留物在内的疏水分子，以及具有硅氧烷键且分子量在 200-1,000,000 之间的化合物（IV）（其中表面活性剂（III）和化合物（IV）不具有可聚合的碳碳双键）。单层膜的亲水基团浓度梯度（Sa/Da）不小于 1.1，其中 Sa 是选自阴离子亲水基团、阳离子亲水基团和羟基的至少一种亲水基团的表面浓度，Da 是亲水基团在单层膜厚度的 1/2 处的深度浓度。
• MODIFIED ACRYLIC RESIN CURED PRODUCT, AND LAMINATE THEREOF, AND PRODUCTION METHODS THEREFOR
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3263635A1

  公开（公告）日：2018-01-03

  The purpose of the present invention is to provide a modified acrylic resin cured product, particularly, a modified acrylic resin film, having excellent lubricity and excellent transparency, and a laminate including the modified acrylic resin film. The modified acrylic resin cured product (C) according to the present invention is obtained by treating the surface of a cured product (X) including an acrylic resin by using a compound (A) containing, in each molecule, one or more anionic hydrophilic groups forming an ion pair with an onium ion of an amino silicone, and one or more groups selected from the group consisting of a group containing a polymerizable carbon-carbon double bond, an amino group, a mercapto group and a hydroxy group.

  本发明的目的是提供一种改性丙烯酸树脂固化物，特别是改性丙烯酸树脂薄膜，它具有极佳的润滑性和极佳的透明度，以及一种包括改性丙烯酸树脂薄膜的层压板。根据本发明的改性丙烯酸树脂固化物（C）是通过使用化合物（A）处理包括丙烯酸树脂的固化物（X）的表面而获得的，化合物（A）在每个分子中含有一个或多个阴离子亲水基团，这些基团与氨基硅的鎓离子形成离子对，还含有一个或多个基团，这些基团选自由含有可聚合碳碳双键的基团、氨基、巯基和羟基组成的组。