2-(1,4-diazepan-1-yl)-N-(2,4-dimethoxyphenyl)acetamide | 1269499-71-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(1,4-diazepan-1-yl)-N-(2,4-dimethoxyphenyl)acetamide
• CAS: 1269499-71-9
• 化学式: C₁₅H₂₃N₃O₃
• 分子量: 293.366
• InChiKey: UCUIVJMIMONQRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  62.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  吡啶-2-磺酰氯 、 2-(1,4-diazepan-1-yl)-N-(2,4-dimethoxyphenyl)acetamide 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以36%的产率得到N-(2,4-dimethoxyphenyl)-2-(4-pyridin-2-ylsulfonyl-1,4-diazepan-1-yl)acetamide
  参考文献：
  名称：

  Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu₄

  摘要：

  Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu(4), a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase parallel synthesis and SAP, of analogs derived from this series will be presented. This series of positive allosteric modulators of mGlu(4) provide critical research tools to further probe the mGlu(4)-mediated effects in Parkinson's disease.

  DOI：

  10.1021/co1000508
• 作为产物：
  描述：

  2-bromo-N-(2,4-dimethoxyphenyl)acetamide 在 盐酸 、 水 、 caesium carbonate 作用下， 以 1,4-二氧六环 、 乙腈 为溶剂， 生成 2-(1,4-diazepan-1-yl)-N-(2,4-dimethoxyphenyl)acetamide
  参考文献：
  名称：

  Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu₄

  摘要：

  Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu(4), a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase parallel synthesis and SAP, of analogs derived from this series will be presented. This series of positive allosteric modulators of mGlu(4) provide critical research tools to further probe the mGlu(4)-mediated effects in Parkinson's disease.

  DOI：

  10.1021/co1000508

文献信息

• Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu₄
  作者：Yiu-Yin Cheung、Rocio Zamorano、Anna L. Blobaum、C. David Weaver、P. Jeffrey Conn、Craig W. Lindsley、Colleen M. Niswender、Corey R. Hopkins

  DOI：10.1021/co1000508

  日期：2011.3.14

  Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu(4), a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase parallel synthesis and SAP, of analogs derived from this series will be presented. This series of positive allosteric modulators of mGlu(4) provide critical research tools to further probe the mGlu(4)-mediated effects in Parkinson's disease.