N-[(E)-[1-amino-2-(4-methoxyphenoxy)ethylidene]amino]pyridine-4-carboxamide | 261362-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[(E)-[1-amino-2-(4-methoxyphenoxy)ethylidene]amino]pyridine-4-carboxamide
• CAS: 261362-97-4
• 化学式: C₁₅H₁₆N₄O₃
• 分子量: 300.317
• InChiKey: CEUOXLGOEFVAJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  98.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-吡啶甲醛 、 N-[(E)-[1-amino-2-(4-methoxyphenoxy)ethylidene]amino]pyridine-4-carboxamide 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以60%的产率得到
  参考文献：
  名称：

  Synthesis and antimycobacterial activity of some isonicotinoylhydrazones

  摘要：

  A series of isonicotinoylhydrazones 2 were prepared by addition of some aryloxyacetonitriles with isonicotinoylhydrazine in basic medium. These compounds have been further reacted with pyridinecarboxaldehydes to give the corresponding pyridylmethyleneamino derivatives 3-5. The new synthesized hydrazones and their pyridylmethyleneamino derivatives were tested for their activity against mycobacteria, Gram-positive and Gram-negative bacteria. The cytotoxicity was also tested. Several compounds showed a good activity against Mycobacterium tuberculosis H37Rv and some isonycotinoylhydrazones 2 showed a moderate activity against a clinically isolated M. tuberculosis which was isoniazid resistant. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(99)00124-5
• 作为产物：
  描述：

  异烟肼 、 4-甲氧基苯氧基乙腈 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以68%的产率得到N-[(E)-[1-amino-2-(4-methoxyphenoxy)ethylidene]amino]pyridine-4-carboxamide
  参考文献：
  名称：

  Synthesis and antimycobacterial activity of some isonicotinoylhydrazones

  摘要：

  A series of isonicotinoylhydrazones 2 were prepared by addition of some aryloxyacetonitriles with isonicotinoylhydrazine in basic medium. These compounds have been further reacted with pyridinecarboxaldehydes to give the corresponding pyridylmethyleneamino derivatives 3-5. The new synthesized hydrazones and their pyridylmethyleneamino derivatives were tested for their activity against mycobacteria, Gram-positive and Gram-negative bacteria. The cytotoxicity was also tested. Several compounds showed a good activity against Mycobacterium tuberculosis H37Rv and some isonycotinoylhydrazones 2 showed a moderate activity against a clinically isolated M. tuberculosis which was isoniazid resistant. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(99)00124-5

文献信息

• Synthesis and antimycobacterial activity of some isonicotinoylhydrazones
  作者：Maria T Cocco、Cenzo Congiu、Valentina Onnis、Maria C Pusceddu、Maria L Schivo、Alessandro De Logu

  DOI：10.1016/s0223-5234(99)00124-5

  日期：1999.12

  A series of isonicotinoylhydrazones 2 were prepared by addition of some aryloxyacetonitriles with isonicotinoylhydrazine in basic medium. These compounds have been further reacted with pyridinecarboxaldehydes to give the corresponding pyridylmethyleneamino derivatives 3-5. The new synthesized hydrazones and their pyridylmethyleneamino derivatives were tested for their activity against mycobacteria, Gram-positive and Gram-negative bacteria. The cytotoxicity was also tested. Several compounds showed a good activity against Mycobacterium tuberculosis H37Rv and some isonycotinoylhydrazones 2 showed a moderate activity against a clinically isolated M. tuberculosis which was isoniazid resistant. (C) 1999 Editions scientifiques et medicales Elsevier SAS.