5-bromo-2-(1H-1,2,3-triazol-1-yl)pyridine | 380380-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-bromo-2-(1H-1,2,3-triazol-1-yl)pyridine
• 英文别名: 5-bromo-2-(triazol-1-yl)pyridine
• CAS: 380380-69-8
• 化学式: C₇H₅BrN₄
• 分子量: 225.047
• InChiKey: FAUKVPVFFMMMBF-UHFFFAOYSA-N

物化性质

• 沸点：
  344.7±52.0 °C(Predicted)
• 密度：
  1.79±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-bromo-2-(1H-1,2,3-triazol-1-yl)pyridine 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium acetate 、 sodium carbonate 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 7.0h， 生成 tert-butyl (S)-3-(3-methyl-8-(6-(1H-1,2,3-triazol-1-yl)pyridin-3-yl)-2-oxy-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)pyrrolidine-1-carbamate
  参考文献：
  名称：

  KETONE DERIVATIVES OF IMIDAZOLES, PHARMACEUTICAL COMBINATIONS AND USES THEREOF

  摘要：

  公开号：

  EP3072893B1
• 作为产物：
  描述：

  1H-1,2,3-三氮唑 、 5-溴-2-氯吡啶 在 potassium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 2.0h， 生成 5-bromo-2-(1H-1,2,3-triazol-1-yl)pyridine
  参考文献：
  名称：

  [EN] OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS
  [FR] DERIVES D'OXAZOLIDINONE UTILISES COMME AGENTS ANTIMICROBIENS

  摘要：

  本发明涉及某些取代苯基噁唑烷酮以及其合成方法。本发明还涉及含有本发明化合物作为抗微生物药物的药物组合物。这些化合物是有用的抗微生物剂，对多种人类和兽医病原体有效，包括革兰氏阳性厌氧细菌，例如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧生物，例如Bacterioides属和Clostridia属物种，以及耐酸生物，例如结核分枝杆菌、埃维分枝杆菌和分枝杆菌属。

  公开号：

  WO2006038100A1

文献信息

• Novel oxazolidinone derivatives and a process for the preparation thereof
  申请人：——

  公开号：US20030166620A1

  公开（公告）日：2003-09-04

  The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

  本发明涉及新颖的噁唑烷酮衍生物，其药用盐以及其制备方法。更具体地，本发明涉及在苯环的4位被杂环和杂芳环取代的噁唑烷酮衍生物。本发明的化合物具有广泛的抗菌谱、优越的抗菌活性和低毒性，因此本发明的化合物可用作抗菌剂。
• [EN] NOVEL OXAZOLIDINONE DERIVATIVES<br/>[FR] NOUVEAUX DERIVES D'OXAZOLIDINONE
  申请人：DONG A PHARM CO LTD

  公开号：WO2005058886A1

  公开（公告）日：2005-06-30

  The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

  本发明涉及新型氧唑啉酮衍生物，其方法以及包含这些衍生物的制药组合物，用于抗生素。本发明的氧唑啉酮衍生物显示出对广谱细菌的抑制活性和较低的毒性。通过将具有羟基的化合物与氨基酸或磷酸反应制备的前药，在其溶解度对水表现出优异效率。此外，本发明的衍生物可能对各种人类和动物病原体发挥强效的抗菌活性，包括革兰氏阳性细菌如葡萄球菌、肠球菌和链球菌，厌氧微生物如拟杆菌和梭菌，以及耐酸微生物如结核分枝杆菌和分枝杆菌。因此，含有氧唑啉酮的组合物用作抗生素。
• Copper-Catalyzed C–N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine Cores
  作者：Sheng Tao、Enhui Ji、Lei Shi、Ning Liu、Liang Xu、Bin Dai

  DOI：10.1055/s-0036-1590893

  日期：2017.12

  copper-catalyzed transfer N-heteroarylation strategy using a C–N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents. A copper-catalyzed

  S. Tao和E. Ji的贡献相等。 抽象的 描述了使用C–N键交换反应的铜催化转移N-杂芳基化策略。该反应可容纳范围广泛的带有卤素原子的吡啶和嘧啶环，它们对于随后的转化具有广泛的用途。该方法提供了直接且操作简单的方法，用于通过交换N杂环取代基来修饰复杂分子。 描述了使用C–N键交换反应的铜催化转移N-杂芳基化策略。该反应可容纳范围广泛的带有卤素原子的吡啶和嘧啶环，它们对于随后的转化具有广泛的用途。该方法提供了直接且操作简单的方法，用于通过交换N杂环取代基来修饰复杂分子。
• Synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring
  作者：Yeong Woo Jo、Weon Bin Im、Jae Keol Rhee、Mi Ja Shim、Won Bae Kim、Eung Chil Choi

  DOI：10.1016/j.bmc.2004.08.025

  日期：2004.11

  group of linezolid was replaced with heteroaromatic ring substituted pyridine moiety, were newly synthesized, and their substituted effects on in vitro and in vivo antibacterial activities were evaluated against four problematic gram-positive strains including drug resistant strains and two gram-negative strains. Most compounds exhibited the enhanced in vitro activities with 4-16-fold and three compounds

  新合成了一系列恶唑烷酮衍生物，其中的利奈唑胺的吗啉代基团被杂芳环取代的吡啶部分取代，并评估了它们对四种有问题的革兰氏阳性菌株的体外和体内抗菌活性的取代作用，包括耐药菌株和两个革兰氏阴性菌株。大多数化合物具有4-16倍的增强的体外活性，三种化合物的体内功效比利奈唑胺高2倍以上。
• [EN] NOVEL OXAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX DERIVES OXAZOLIDINONE ET PROCESSUS DE PREPARATION DE CES DERIVES
  申请人：DONG A PHARM CO LTD

  公开号：WO2001094342A1

  公开（公告）日：2001-12-13

  The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

  本发明涉及新型噁唑烷衍生物，其药学上可接受的盐以及其制备方法。更具体地说，本发明涉及在苯环的4位上以杂环和杂芳环取代的吡啶或嘧啶基团的噁唑烷衍生物。本发明的化合物具有广泛的抗菌谱、优越的抗菌活性和低毒性，因此本发明的化合物可用作抗菌剂。