4-(2-bromoethoxy)-4-oxobutanoic acid | 199982-32-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(2-bromoethoxy)-4-oxobutanoic acid
• 英文别名: 3-((2-Bromoethyl)oxycarbonyl)propanoic acid
• CAS: 199982-32-6
• 化学式: C₆H₉BrO₄
• 分子量: 225.039
• InChiKey: MEQSLFRDECNCTH-UHFFFAOYSA-N

物化性质

• 沸点：
  150 °C(Press: 1-2 Torr)
• 密度：
  1.620±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2-bromoethoxy)-4-oxobutanoic acid 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以99%的产率得到
  参考文献：
  名称：

  Grafting Efficiency of Synthetic Polymers onto Biomaterials: A Comparative Study of Grafting-from versus Grafting-to

  摘要：

  In the present study, the two grafting techniques grafting-from - by activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) - and grafting-to - by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) - were systematically compared, employing cellulose as a substrate. In order to obtain a meaningful comparison, it is crucial that the graft lengths of the polymers that are grafted from and to the substrates are essentially identical. Herein, this was achieved by utilizing the free polymer formed in parallel to the grafting from reaction as the polymer for the grafting-to reaction. Four graft lengths were investigated, and the molar masses of the four free polymers (21 <= M-n <= 100 kDa; 1.07 <= D-M <= 1.26), i.e. the polymers subsequently employed in the grafting to reaction, were shown to be in the same range as the molar masses of the polymers grafted from the surface (23 <= M-n <= 87 kDa; 1.08 <= D-M <= 1.31). The molecular weights of the chains grafted from the surface were established after cleavage from the cellulose substrates via size exclusion chromatography (SEC). High-resolution Fourier transform infrared microscopy (FT-IRM) was employed as an efficient tool to study the spatial distribution of the polymer content on the grafted substrates. In addition, the functionalizeid substrates were analyzed by X-ray photoelectron spectroscopy (XPS), contact angle (CA) measurements, and field-emission scanning electron microscopy (FE-SEM). For cellulose substrates modified via the grafting-from approach, the content of polymer on the surfaces increased with increasing graft length, confirming the possibility to tailor not only the length of the polymer grafts but also the polymeric content on the surface. In comparison, for the grafting to reaction, the grafted content could not be controlled by varying the length of the preformed polymer: the polymer content was essentially the same for the four graft lengths. Consequently, the obtained results, when employing cellulose as a substrate and under these conditions, suggest that the grafting-from approach is superior to the grafting-to technique with respect to controlling the distribution of the polymeric content on the surface.

  DOI：

  10.1021/bm3013132
• 作为产物：
  描述：

  丁二酸酐 、 2-溴乙醇 在 4-二甲氨基吡啶 作用下， 以 氯仿 为溶剂， 反应 63.0h， 以48%的产率得到4-(2-bromoethoxy)-4-oxobutanoic acid
  参考文献：
  名称：

  Nitrosated and nitrosylated diuretic compounds, compositions and methods of use

  摘要：

  该发明描述了新颖的亚硝基化和/或亚硝酰化利尿化合物或其药用盐，以及包含至少一种亚硝基化和/或亚硝酰化利尿化合物的新型组合物，以及可选地至少一种一氧化氮供体和/或至少一种治疗剂。该发明还提供了包含该发明中至少一种利尿化合物的新型组合物和试剂盒，该利尿化合物可选择地亚硝基化和/或亚硝酰化，并且可选地至少一种一氧化氮供体化合物和/或至少一种治疗剂。该发明还提供了用于(a)治疗由于过多水分和/或电解贮留引起的疾病；(b)治疗心血管疾病；(c)治疗肾血管疾病；(d)治疗糖尿病；(e)治疗由氧化应激引起的疾病；(f)治疗内皮功能障碍；(g)治疗由内皮功能障碍引起的疾病；(h)治疗肝硬化；(j)治疗子痫前期；(k)治疗骨质疏松症；和(l)治疗肾病的方法。

  公开号：

  US20050059655A1

文献信息

• Convergent Synthesis of Glycodendropeptides by Click Chemistry Approaches
  作者：Wioleta Kowalczyk、Ainhoa Mascaraque、Macarena Sánchez-Navarro、Javier Rojo、David Andreu

  DOI：10.1002/ejoc.201200428

  日期：2012.8

  We thank the Spanish Ministry of Science and Innovation (MICINN) for financial support (BIO2008-04487-CO3-02 and SAF2009-24899 to D. A. and CTQ2008-01694/BQU and CTQ2011-23410 to J. R). W. K., and A. M. thank MICINN for Juan de la Cierva and FPI fellowships, respectively.

  我们感谢西班牙科学与创新部 (MICINN) 的财政支持 (BIO2008-04487-CO3-02 和 SAF2009-24899 到 DA 和 CTQ2008-01694/BQU 和 CTQ2011-23410 到 J. R)。WK 和 AM 分别感谢 MICINN 为 Juan de la Cierva 和 FPI 奖学金。
• KINASE MODULATORS FOR THE TREATMENT OF CANCER
  申请人：Burnet Michael W.

  公开号：US20130045938A1

  公开（公告）日：2013-02-21

  A method of treating cancer in which a compound that inhibits the expression, production or release of IL-10 by immune cells is combined with a compound that stimulates the production of IL-12 when given in combination with, or in the presence of TNFa. Said method is effective when provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.

  一种治疗癌症的方法，其中抑制免疫细胞表达、产生或释放IL-10的化合物与在与或存在TNFa时刺激IL-12产生的化合物结合。该方法在标准治疗（特别是使用细胞毒性药物的化疗和其他形式的免疫疗法，包括治疗性疫苗）之外提供时是有效的。
• NITROSATED AD NITROSYLATED DIURETIC COMPOUDS, COMPOSITIONS AND METHODS OF USE
  申请人：Nitromed, Inc.

  公开号：EP1668008A2

  公开（公告）日：2006-06-14
• EP1668008A4
  申请人：——

  公开号：EP1668008A4

  公开（公告）日：2009-02-25
• US7282519B2
  申请人：——

  公开号：US7282519B2

  公开（公告）日：2007-10-16