α-oxy-β-m-cresyloxy-propane | 6773-95-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: α-oxy-β-m-cresyloxy-propane
• 英文别名: α-Oxy-β-m-kresoxy-propan；Propylenglykol-β-m-tolyl-aether；2-(3-Methylphenoxy)propan-1-ol
• CAS: 6773-95-1
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: GUCYUBUHYYOCKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯-1-丙醇 、 alkaline earth salt of/the/ methylsulfuric acid 生成 α-oxy-β-m-cresyloxy-propane
  参考文献：
  名称：

  DE282991

  摘要：

  公开号：

文献信息

• 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES
  申请人：Galley Guido

  公开号：US20100029589A1

  公开（公告）日：2010-02-04

  The invention relates to compounds of formula I wherein R 1 , R 2 , X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of such compounds. The compounds are useful for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

  该发明涉及公式I的化合物，其中R1、R2、X、Y和n在规范中定义，并且其药学上可接受的酸盐。该发明还提供了制备这种化合物的药物组合物和方法。这些化合物可用于治疗与痕量胺相关受体的生物功能相关的疾病，这些疾病包括抑郁症、焦虑症、躁郁症、注意缺陷多动障碍、与压力有关的疾病、精神疾病、精神分裂症、神经系统疾病、帕金森病、神经退行性疾病、阿尔茨海默病、癫痫、偏头痛、物质滥用和代谢紊乱、进食障碍、糖尿病、糖尿病并发症、肥胖症、脂质代谢异常、能量消耗和吸收异常、体温稳态异常、睡眠和昼夜节律异常、心血管疾病。
• An efficient catalyst for ring opening of epoxides with phenol and thiophenol under solvent-free conditions
  作者：Hong-fei Lu、Jun-tao Zhou、He-long Cheng、Lei-lei Sun、Fei-fei Yang、Run-ze Wu、Yu-hua Gao、Zhi-bin Luo

  DOI：10.1016/j.tet.2013.10.098

  日期：2013.12

  An efficient and rapid procedure for ring opening reaction of various epoxides with phenol and thiophenol derivatives was developed. The procedure can be obtained at room temperature under solvent-free condition in presence of (C4H12N2)(2)[Bicl(6)]Cl center dot H2O (1 mol %). This catalyst can be reused several times without significant loss of activity. (C) 2013 Elsevier Ltd. All rights reserved.
• Benzoxazol- and benzothiazolamine derivatives
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0184257B1

  公开（公告）日：1990-07-25
• 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2321287B1

  公开（公告）日：2015-11-11
• US4861785A
  申请人：——

  公开号：US4861785A

  公开（公告）日：1989-08-29