p-2,2,3,3-Tetrafluoropropoxy-m-nitrobenzoic acid | 364379-57-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-2,2,3,3-Tetrafluoropropoxy-m-nitrobenzoic acid
• 英文别名: 3-Nitro-4-(2,2,3,3-tetrafluoropropoxy)benzoic acid
• CAS: 364379-57-7
• 化学式: C₁₀H₇F₄NO₅
• mdl: MFCD02852993
• 分子量: 297.163
• InChiKey: OGYSMSSZAZVKME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  胆固醇 、 p-2,2,3,3-Tetrafluoropropoxy-m-nitrobenzoic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以88%的产率得到Cholesteryl p-2,2,3,3-Tetrafluoropropoxy-m-nitrobenzoate
  参考文献：
  名称：

  Synthesis and mesomorphic properties of cholesteryl p-polyfluoroalkoxy-m-nitrobenzoate

  摘要：

  Homologous cholesteryl p-polyRuoroalkoxy-m-nitrobenzoate were synthesized and their phase transition behaviours were studied. Due to the activation of chlorine atom in aromatic ring by introducing o-nitro and p-trifluoromethyl groups, the fluoroalkoxylation can directly be processed using potassium carbonate as base. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00386-4
• 作为产物：
  描述：

  4-氯-3-硝基三氟甲苯 在 硫酸 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 p-2,2,3,3-Tetrafluoropropoxy-m-nitrobenzoic acid
  参考文献：
  名称：

  Synthesis and mesomorphic properties of cholesteryl p-polyfluoroalkoxy-m-nitrobenzoate

  摘要：

  Homologous cholesteryl p-polyRuoroalkoxy-m-nitrobenzoate were synthesized and their phase transition behaviours were studied. Due to the activation of chlorine atom in aromatic ring by introducing o-nitro and p-trifluoromethyl groups, the fluoroalkoxylation can directly be processed using potassium carbonate as base. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00386-4

文献信息

• Synthesis and mesomorphic properties of cholesteryl p-polyfluoroalkoxy-m-nitrobenzoate
  作者：Kan Wang、Hengfeng Li、Jianxun Wen

  DOI：10.1016/s0022-1139(01)00386-4

  日期：2001.7

  Homologous cholesteryl p-polyRuoroalkoxy-m-nitrobenzoate were synthesized and their phase transition behaviours were studied. Due to the activation of chlorine atom in aromatic ring by introducing o-nitro and p-trifluoromethyl groups, the fluoroalkoxylation can directly be processed using potassium carbonate as base. (C) 2001 Elsevier Science B.V. All rights reserved.