(4-bromomethyl)benzaldehyde dimethyl acetal | 138498-84-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-bromomethyl)benzaldehyde dimethyl acetal
• 英文别名: 4-(dimethoxymethyl)benzyl-bromide；1-(Bromomethyl)-4-(dimethoxymethyl)benzene
• CAS: 138498-84-7
• 化学式: C₁₀H₁₃BrO₂
• 分子量: 245.116
• InChiKey: IAMBDSVJPKYULF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-bromomethyl)benzaldehyde dimethyl acetal 在 硫酸 、 sodium hydride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 44.0h， 生成 [4-((1,2:3,4-di-O-isopropylidene-α-D-galactopyranos-6-oxy)methyl)phenyl]-bis(5-ethoxycarbonyl-4-ethyl-3-methyl-2-pyrryl)methane
  参考文献：
  名称：

  Synthesis and investigation of glycosylated mono- and diarylporphyrins for photodynamic therapy

  摘要：

  The synthesis of a diaryl substituted porphyrin bearing a galactosyl and a cholesteryloxy substituent and of a galactosyl substituted monoaryl porphyrin is described. The spectroscopic and aggregation properties of both compounds were investigated. The galactosyl substituted monoaryl porphyrin (12) was efficiently incorporated into liposomes and lipoproteins whereas the diaryl porphyrin showed no interaction with these lipids. Furthermore the binding constants of compound 12 to HDL, LDL, VLDL, and PE and DMPC liposomes were estimated.

  DOI：

  10.1016/s0968-0896(99)00133-9
• 作为产物：
  描述：

  甲醇 、 4-溴甲基苯甲醛 在 对甲苯磺酸 作用下， 反应 2.0h， 以100%的产率得到(4-bromomethyl)benzaldehyde dimethyl acetal
  参考文献：
  名称：

  Dynamic combinatorial chemistry with hydrazones: libraries incorporating heterocyclic and steroidal motifs

  摘要：

  我们通过一系列引入杂环基序的新型构建单元，拓展了基于脒的动态组合化学的可能性。合成程序可以高效地获得具有通用结构 (MeO)2CH-杂环-C(O)NHNH2 的构建单元，这些构建单元源自含有胺和酯官能团的杂环化合物。我们还报道了在有机溶剂中用三氟乙酸对这些构建单元进行去保护后形成的宏环 N-酰基脒的平衡分布情况。此外，描述了这些基于杂环的构建单元与我们基于胆酸盐的构建单元的混合行为，特别是观察到在“校对”后消失的动力学中间体。

  DOI：

  10.1039/b917146k

文献信息

• [EN] SUBSTITUTED BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSÉS DE BENZOPYRAN SUBSTITUÉS, LEURS COMPOSITIONS ET UTILISATIONS
  申请人：OLEMA PHARMACEUTICALS INC

  公开号：WO2014203132A1

  公开（公告）日：2014-12-24

  Benzopyran compounds with anti-estrogenic activity are provided as Formula I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII, XIV, XV, XVI, XVII and XVIII. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.

  提供具有抗雌激素活性的苯并吡喃化合物，其化学式为I、II、III、IV、V、VI、VII、VIII、IX、X、XI、XII、XIII、XIV、XV、XVI、XVII和XVIII。这些化合物对于治疗或预防哺乳动物，包括人类，通过雌激素受体调节的各种疾病是有用的。
• "Living" polymers and process for their preparation
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0068887A1

  公开（公告）日：1983-01-05

  Process for preparing «living» polymers from acrylic- type or maleimide monomers and organosilicon, -tin or -germanium initiators, and the «living» polymers prepared thereby.

  用丙烯酸类或马来酰亚胺类单体和有机硅、锡或锗引发剂制备 "活 "聚合物的工艺，以及由此制备的 "活 "聚合物。
• Living polymers and process for their preparation
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0145263A1

  公开（公告）日：1985-06-19

  Process for preparing "living" polymers from acrylic- type or maleimide monomers and organosilicon, -tin, or -germanium initiators, the "living" polymers prepared thereby, and coating compositions comprising them.

  用丙烯酸类或马来酰亚胺类单体和有机硅、锡或锗引发剂制备 "活 "聚合物的工艺，由此制备的 "活 "聚合物，以及包含这些聚合物的涂料组合物。
• HIV protease inhibitors useful for the treatment of aids
  申请人：MERCK & CO. INC.

  公开号：EP0434365A2

  公开（公告）日：1991-06-26

  Compounds of the form, A-G-B-B-J wherein A is an amine protecting group or urethane, G a dipeptide isostere substituted with a basic amine nitrogen, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

  A-G-B-B-J 形式的化合物 其中 A 是胺保护基团或氨基甲酸乙酯，G 是被碱性胺氮取代的二肽异构体，B 是氨基酸或其类似物，J 是小的末端基团。这些化合物作为化合物、药学上可接受的盐、药物组合成分，无论是否与其他抗病毒药物、免疫调节剂、抗生素或疫苗结合使用，都可用于抑制 HIV 蛋白酶、预防或治疗 HIV 感染和治疗 AIDS。还描述了治疗艾滋病的方法和预防或治疗艾滋病毒感染的方法。
• PORPHYRIN AND CONDUCTIVE POLYMER COMPOSITIONS FOR USE IN SOLID-STATE ELECTRONIC DEVICES
  申请人：Laird Darin W.

  公开号：US20090023842A1

  公开（公告）日：2009-01-22

  Compositions comprising porphyrinic macrocycles and conjugated polymers such as polythiophene for use in organic electronic devices including solar cells are presented. Covalent linkage of a porphyrinic macrocycle to a polymer allows tuning of electronic and spectroscopic properties of conjugated polymers and can improve the heat stability of the system relative to a blended comparison. A composition comprising: at least one polymer comprising at least one porphyrinic macrocycle covalently linked to at least one conjugated polymer, wherein the porphyrinic macrocycle is metal-free is also presented. Inks can be formulated. Methods of making are provided.