2-(5-(benzyloxy)-1H-indol-3-yl)-1,4-naphthoquinone | 1027340-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(5-(benzyloxy)-1H-indol-3-yl)-1,4-naphthoquinone
• 英文别名: 2-(5-phenylmethoxy-1H-indol-3-yl)naphthalene-1,4-dione
• CAS: 1027340-43-7
• 化学式: C₂₅H₁₇NO₃
• 分子量: 379.415
• InChiKey: UDWHUSLDAKSAHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  59.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-苄氧基吲哚 、 1,4-萘醌 在 碘 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以70%的产率得到2-(5-(benzyloxy)-1H-indol-3-yl)-1,4-naphthoquinone
  参考文献：
  名称：

  Novel Synthesis of 3‐Indolylquinones catalyzed by Molecular Iodine under Ultrasonic Irradiation

  摘要：

  The conjugate addition reactions of indoles with quinones were catalyzed efficiently by molecular iodine under ultrasonic irradiation to afford 3-indolylquinones in good to excellent yields, which provided a novel, mild, convenient approach for the preparation of 3-indolylquinones.

  DOI：

  10.1080/00397910701873490

文献信息

• Novel Synthesis of 3‐Indolylquinones catalyzed by Molecular Iodine under Ultrasonic Irradiation
  作者：Bing Liu、Shun‐Jun Ji、Xiao‐Ming Su、Shun‐Yi Wang

  DOI：10.1080/00397910701873490

  日期：2008.3.28

  The conjugate addition reactions of indoles with quinones were catalyzed efficiently by molecular iodine under ultrasonic irradiation to afford 3-indolylquinones in good to excellent yields, which provided a novel, mild, convenient approach for the preparation of 3-indolylquinones.