2,3,4-trichloro-thiophenol | 57730-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 2,3,4-trichloro-thiophenol
• 英文别名: 2.3.4-Trichlor-1-mercapto-benzol；2.3.4-Trichlor-phenylmercaptan；2,3,4-Trichlor-thiophenol；2,3,4-Trichlor-phenylmercaptan；2,3,4-Trichlorobenzenethiol
• CAS: 57730-95-7
• 化学式: C₆H₃Cl₃S
• 分子量: 213.515
• InChiKey: PJFUHFZHSSLCTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3,4-trichloro-thiophenol 、 氯乙酸 在 sodium hydroxide 作用下， 生成 C.I.溶剂蓝98
  参考文献：
  名称：

  US1763556

  摘要：

  公开号：
• 作为产物：
  描述：

  三氯苯 在 二氯化二硫 、 三氯化铁 作用下， 生成 2,3,4-trichloro-thiophenol
  参考文献：
  名称：

  DE745270

  摘要：

  公开号：

文献信息

• DEUTERATED NUCLEOSIDE PRODRUGS USEFUL FOR TREATING HCV
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20140309164A1

  公开（公告）日：2014-10-16

  Deuterated nucleoside analogs of Formula (I) and the pharmaceutically acceptable salts thereof are provided by this disclosure The variables, e.g., B 1 , Y, R 1 , R 2 , R 3 , R 3 ′, R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 carry definitions set forth in the disclosure. Compounds of Formula (I) are deuterated at one or more positions and the deuterium enrichment at each deuterated positions is at least 50%. Compounds and salts of Formula (I) are useful for treating viral infections, including HCV infections.

  本公开提供了式（I）的氘代核苷类似物及其药用盐。变量，例如B1、Y、R1、R2、R3、R3'、R4、R5、R6、R7、R8和R9在本公开中有定义。式（I）的化合物在一个或多个位置上被氘代，且每个氘代位置的氘富集度至少为50%。式（I）的化合物和盐对治疗病毒感染，包括HCV感染，具有用处。
• [EN] METHODS FOR THE PREPARATION OF DIASTEREOMERICALLY PURE PHOSPHORAMIDATE PRODRUGS<br/>[FR] PROCÉDÉS POUR LA PRÉPARATION DE PROMÉDICAMENTS DE PHOSPHORAMIDATE DIASTÉRÉOMÉRIQUEMENT PUR
  申请人：MEDIVIR AB

  公开号：WO2016041877A1

  公开（公告）日：2016-03-24

  Methods for the preparation of diastereomerically pure phosphoramidate prodrugs of nucleosides, and intermediates useful for the preparation are provided. The nucleosides are useful for the treatment of hepatitis C and cancer.

  提供了用于制备核苷酸磷酰胺酯前药的对映异构纯净方法，以及用于制备的中间体。这些核苷酸对治疗丙型肝炎和癌症具有用途。
• [EN] 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS<br/>[FR] COMPOSES 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE POUR LE TRAITEMENT DE LA TUBERCULOSE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005042542A1

  公开（公告）日：2005-05-12

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

  本发明提供了一种由以下一般式表示的2,3-二氢-6-硝基咪唑[2,1-b]噁唑化合物：(1)在上述式(1)中，R1代表氢原子或C1-C6烷基，n代表0至6的整数，R1和-(CH2)nR2可以与下面的式(30)一起形成一个螺环，与相邻的碳原子一起（在下面的式中，RRR代表可能在哌啶环上具有取代基的哌啶基），(30)和R2代表苯并噻唑氧基、喹啉氧基、吡啶氧基或类似物。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型耐酸细菌具有出色的杀菌作用。
• Phenothiazine derivatives and their method of use
  申请人：Rozman K. Karl

  公开号：US20050288279A1

  公开（公告）日：2005-12-29

  Novel phenothiazine derivatives and their use in the treatment of diabetes mellitus (type I and type II), and as an ovulation inhibitor (contraceptive), cancer chemotherapeutic and/or prophylactic agent, anti-obesity drug (body weight regulator), and immunostimulant.

  新型苯并噻嗪衍生物及其在糖尿病（I型和II型）治疗、作为排卵抑制剂（避孕药）、癌症化疗和/或预防药、抗肥胖药（体重调节剂）和免疫刺激剂方面的应用。
• Cyanoalkylamino derivatives as protease inhibitors
  申请人：Black Cameron

  公开号：US20050014941A1

  公开（公告）日：2005-01-20

  The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by unregulated cysteine protease activity, in particular cathepsin K utilizing these compounds and methods of preparing these compounds are also disclosed.

  本发明涉及一种新型的氰基烷基氨基衍生物，其为半胱氨酸蛋白酶抑制剂，例如cathepsin K、S、B和L，特别是cathepsin K。本发明还涉及包含这些化合物的药物组合物，治疗由不受调节的半胱氨酸蛋白酶活性介导的疾病的方法，特别是利用这些化合物治疗cathepsin K，以及制备这些化合物的方法。