4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid | 124168-73-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid
• 英文别名: (2S)-1-[2-[(4-aminobenzoyl)amino]acetyl]-N-[(2R)-1-[[(2R)-1-(hydroxyamino)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
• CAS: 124168-73-6
• 化学式: C₂₃H₃₄N₆O₆
• 分子量: 490.6
• InChiKey: WWHUHFFMOPIVKB-OLMNPRSZSA-N

物化性质

• 密度：
  1.288±0.06 g/cm3(Predicted)
• 溶解度：
  H2O：1 mg/mL
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解，也未有已知的危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  183
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• SURGICAL STAPLER WITH END EFFECTOR COATING
  申请人：Ethicon LLC

  公开号：EP3415176A1

  公开（公告）日：2018-12-19

  Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

  提供了促进伤口愈合的方法和设备。一般来说，提供的手术订书机和订书机组件上有一层涂层，该涂层可选择性地控制至少一种基质金属蛋白酶（MMP）抑制剂与订书机或订书机组件外表面之间的相互作用。
• SURGICAL FASTENER DEVICE FOR THE PREVENTION OF ECM DEGRADATION
  申请人：Ethicon LLC

  公开号：EP3415179A1

  公开（公告）日：2018-12-19

  Methods and devices are provided for promoting wound healing. In general, surgical staplers and staple components are provided having an effective amount of at least matrix metalloproteinase (MMP) inhibitor being effective to prevent MMP-mediated extracellular matrix degeneration during wound healing in tissue.

  提供了促进伤口愈合的方法和设备。一般来说，提供的手术订书机和订书机组件至少含有有效量的基质金属蛋白酶（MMP）抑制剂，可有效防止组织伤口愈合过程中 MMP 介导的细胞外基质变性。
• SURGICAL STAPLER WITH CONTROLLED HEALING
  申请人：Ethicon LLC

  公开号：EP3415178A1

  公开（公告）日：2018-12-19

  Methods and devices are provided for promoting wound healing. In general, surgical staplers and staple components are provided having an effective amount of at least matrix metalloproteinase (MMP) inhibitor being effective to prevent MMP-mediated extracellular matrix degeneration during wound healing in tissue.

  提供了促进伤口愈合的方法和设备。一般来说，提供的手术订书机和订书机组件至少含有有效量的基质金属蛋白酶（MMP）抑制剂，可有效防止组织伤口愈合过程中 MMP 介导的细胞外基质变性。
• Surgical stapler with end effector coating
  申请人：Ethicon LLC

  公开号：US10939911B2

  公开（公告）日：2021-03-09

  Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

  提供了促进伤口愈合的方法和设备。一般来说，提供的手术订书机和订书机组件上有一层涂层，该涂层可选择性地控制至少一种基质金属蛋白酶（MMP）抑制剂与订书机或订书机组件外表面之间的相互作用。
• Surgical fastener device for the prevention of ECM degradation
  申请人：Ethicon LLC

  公开号：US11058804B2

  公开（公告）日：2021-07-13

  Methods and devices are provided for promoting wound healing. In general, surgical staplers and staple components are provided having an effective amount of at least matrix metalloproteinase (MMP) inhibitor being effective to prevent MMP-mediated extracellular matrix degeneration during wound healing in tissue.

  提供了促进伤口愈合的方法和设备。一般来说，提供的手术订书机和订书机组件至少含有有效量的基质金属蛋白酶（MMP）抑制剂，可有效防止组织伤口愈合过程中 MMP 介导的细胞外基质变性。