lithium N-ethylanilide | 54962-15-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: lithium N-ethylanilide
• 英文别名: Lithium-N-aethyl-anilid；lithium N-ethyl-N-phenylamide；lithium;ethyl(phenyl)azanide
• CAS: 54962-15-1
• 化学式: C₈H₁₀LiN
• 分子量: 127.115
• InChiKey: ADOHEESZLPHEMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.28
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  lithium N-ethylanilide 在 甲醇 、 氢氧化钾 、 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 生成 N-乙基苯胺
  参考文献：
  名称：

  Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks

  摘要：

  Anodic methoxylation of various types of N-(fluoroethyl)amines, ArRNCH(2)R(f) (R(f) = CF3, CHF2, CH2F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position a to the fluoromethyl (R(f)) group, depending on the R(f) and R groups. The effect of the R(f) group on the promotion of the anodic alpha-methoxylation decreased in the order CF3, CHF2, and CH2F. This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the alpha-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines. The alpha-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds alpha to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods.

  DOI：

  10.1021/jo00082a018
• 作为产物：
  描述：

  N-乙基苯胺 生成 lithium N-ethylanilide
  参考文献：
  名称：

  CRISTAN H.-J.; CHENE A.; CHRISTOL H., SYNTHESIS, 1980, NO 7, 551-554

  摘要：

  DOI：
• 作为试剂：
  描述：

  十二腈 在 lithium N-ethylanilide 作用下， 生成 3-amino-2-decyl-tetradec-2-enenitrile
  参考文献：
  名称：

  McCorkle, Iowa State College Journal of Science, 1939, vol. 14, p. 64

  摘要：

  DOI：

文献信息

• Preparation of Tertiary Amines via the Oxidative Coupling of Polyfunctional Aryl and Heteroaryl Amidocuprates
  作者：Paul Knochel、Marcel Kienle、Srinivas Reddy Dubbaka、Vicente del Amo

  DOI：10.1055/s-2007-965941

  日期：2007.4

  Highly functionalized tertiary amines can be prepared by the oxidative coupling of polyfunctional lithium amidocuprates using chloranil as an oxidant. A high functional group tolerance and insensibility to steric hindrance characterize this general amination reaction. Herein, we report a practical procedure for the preparation of aryl and heteroaryl tertiary amines.

  高度官能化的叔胺可以通过使用四氯苯醌作为氧化剂的多官能氨基铜酸锂的氧化偶联来制备。这种通用胺化反应具有高官能团耐受性和对空间位阻不敏感的特点。在此，我们报告了一种制备芳基和杂芳基叔胺的实用程序。
• Origin of Stereochemistry in the α-Amino Acid Esters and Amides Generated from Optically Active Zirconaaziridine Complexes¹
  作者：Daniel A. Gately、Jack R. Norton

  DOI：10.1021/ja953893h

  日期：1996.1.1

  Methane elimination from ethylenebis(tetrahydroindenyl)(methyl)zirconium amides (R = alkyl or aryl, R‘ = aryl) (S,S)-26 gives a mixture of epimeric zirconaaziridines 25 and 30. When zirconaaziridines with R = alkyl are trapped with ethylene carbonate as they are formed, methyl α-amino acid esters 16 are obtained in poor ee (+14% to −56%); the ee's of 16 reflect the kinetic ratio of 25 to 30. When epimeric

  从亚乙基双（四氢茚基）（甲基）锆酰胺（R = 烷基或芳基，R' = 芳基）(S,S)-26 中消除甲烷得到差向异构锆氮丙啶 25 和 30 的混合物。在形成碳酸亚乙酯时，在较差的ee（+14%至-56%）下获得α-氨基酸甲酯16；16 的 ee 反映了 25 到 30 的动力学比。当在加入碳酸亚乙酯之前允许具有 R = 芳基的差向异构锆氮丙啶平衡时，酯 16 的 ee 大于 96%。当 R = 烷基的差向异构 zirconaaziridines 在加入碳酸亚乙酯之前被允许平衡时，在 21-97% ee 中获得 16。当异氰酸酯加入到锆氮丙啶差向异构体 25 和 30 中时，得到的苯基甘氨酰胺的 ee 为 80-99%。ee' 当 R' 为邻茴香基时，酯和酰胺的 s 比当 R' 为 Ph 时更好。 Curtin-Hammett-Winstein-Holness 分析解释了酯和酰胺的立体化学。当差向异构体的平衡混合物
• From allylic alcohols to chiral tertiary homoallylic alcohol: palladium-catalyzed asymmetric allylation of isatins
  作者：Xiang-Chen Qiao、Shou-Fei Zhu、Qi-Lin Zhou

  DOI：10.1016/j.tetasy.2009.04.012

  日期：2009.6

  A palladium-catalyzed asymmetric allylation of isatins with allylic alcohols as an allyl donor was developed by using chiral spiro phosphoramidite ligands. A variety of chiral tertiary homoallylic alcohols 3-allyl-3-hydroxy-2-oxindoles were prepared directly from allylic alcohols in one step with excellent yields and moderate enantioselectivities. This represents the first catalytic asymmetric allylation

  通过使用手性螺环亚磷酰胺配体，开发了钯催化的靛红与烯丙基醇作为烯丙基供体的不对称烯丙基化反应。一步一步直接从烯丙基醇制备各种手性叔均烯丙基醇3-烯丙基-3-羟基-2-氧吲哚，并具有优异的收率和中等的对映选择性。这代表用烯丙基醇作为烯丙基化剂的酮的第一次催化不对称烯丙基化。
• Method for producing titanium complex
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0970964A2

  公开（公告）日：2000-01-12

  There is disclosed a method for producing an alkoxytitanium complex of formula ( I ),    wherein Cp is a group having cyclopentadiene-type anion skeleton, A represents a carbon atom or silicon atom, R1, R2, R3, R4, R5 and R6 each independently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms which optionally may be substituted and the like, and R7 each independently represents an alkyl group having 1 to 10 carbon atoms which may be substituted and the like.

  本发明公开了一种生产式 ( I ) 烷氧基钛络合物的方法、 其中 Cp 是具有环戊二烯型阴离子骨架的基团，A 代表碳原子或硅原子，R1、R2、R3、R4、R5 和 R6 各自独立地代表氢原子、具有 1 至 10 个碳原子且可被取代的烷基等，R7 各自独立地代表具有 1 至 10 个碳原子且可被取代的烷基等。
• Enantioselective alkylation of tricyclic compounds
  申请人：Schering Corporation

  公开号：EP2189447A1

  公开（公告）日：2010-05-26

  A process for the preparation of a compound represented by formula I is disclosed.

  一种制备式 I 所代表化合物的工艺 的化合物的制备工艺。