3-Hydroxy-5-methoxy-3-methylpentansaeure-(1) | 819-33-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxy-5-methoxy-3-methylpentansaeure-(1)
• 英文别名: 3-Hydroxy-5-methoxy-3-methylpentanoic acid
• CAS: 819-33-0
• 化学式: C₇H₁₄O₄
• 分子量: 162.186
• InChiKey: GCCJLROHIOHEBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基丁-2-酮 在 sodium hydroxide 、 锌 作用下， 以 乙醚 、 乙醇 为溶剂， 生成 3-Hydroxy-5-methoxy-3-methylpentansaeure-(1)
  参考文献：
  名称：

  影响脂质代谢的药物。二。酸的类似物。

  摘要：

  DOI：

  10.1021/jm00338a033

文献信息

• ANTIBODIES DIRECTED TO GPNMB AND USES THEREOF
  申请人：Pollack Vincent A.

  公开号：US20130244255A1

  公开（公告）日：2013-09-19

  The present invention relates to antibodies with specificity to GPNMB, and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides biomarkers for evaluating the effects of therapeutic methods and uses of the antibodies with specificity to GPNMB.
• Agents Affecting Lipid Metabolism. II. Analogs of Mevalonic Acid¹
  作者：Leslie G. Humber、Michael Kraml、Jean Dubuc、Roger Gaudry

  DOI：10.1021/jm00338a033

  日期：1963.3