DL-N-benzoylhomocysteine thiolactone | 39837-09-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-N-benzoylhomocysteine thiolactone
• 英文别名: N-benzoyl homocysteine thiolactone；N-Benzoyl-DL-homocystein-thiolacton；N-Benzoyl-homocysteinlacton；3-benzoylamino-dihydro-thiophen-2-one；(+/-)-3-Benzoylamino-dihydro-thiophen-2-on；N-(2-oxotetrahydrothiophen-3-yl)benzamide；N-(2-oxothiolan-3-yl)benzamide
• CAS: 39837-09-7
• 化学式: C₁₁H₁₁NO₂S
• 分子量: 221.28
• InChiKey: GHUVBMYECVDQDY-UHFFFAOYSA-N

物化性质

• 沸点：
  498.2±38.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  DL-N-benzoylhomocysteine thiolactone 在 sodium hydroxide 、 air 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 生成 Bis-α-N-benzoyl-DL-homocystin-dihydroxamsaeure
  参考文献：
  名称：

  Knobler,Y. et al., Israel Journal of Chemistry, 1970, vol. 8, p. 639 - 645

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 tin 、 丙酮 作用下， 生成 DL-N-benzoylhomocysteine thiolactone
  参考文献：
  名称：

  du Vigneaud; Patterson; Hunt, Journal of Biological Chemistry, 1938, vol. 126, p. 217,225

  摘要：

  DOI：

文献信息

• Method of preparing ligands for hydrophobic interaction chromatography
  申请人：Johansson Bo-Lennart

  公开号：US20060175258A1

  公开（公告）日：2006-08-10

  The invention is a method of preparing multimodal ligands for hydrophobic interaction chromatography (HIC), which comprises providing a cyclic scaffold comprising a thiol, an amine and a carbonyl group; derivatisation of the nitrogen with a reagent to introduce a primary interaction; and aminolysis of the resulting derivative, whereby a secondary interaction is introduced next to the carbonyl; wherein at least one of the primary interaction and the secondary interaction comprises a hydrophobic group and wherein non of said interactions comprises charged groups, i.e. ion exchange ligands. The invention also encompasses a separation medium comprising such multimodal ligands immobilised to a base matrix.

  这项发明是一种制备用于疏水相互作用色谱（HIC）的多模态配体的方法，包括提供一个包含硫醇、胺和羰基的环状支架；将氮基衍生化以引入一种初级相互作用；以及氨解作用于所得衍生物，从而在羰基旁引入一种次级相互作用；其中初级相互作用和/或次级相互作用中至少有一种包括疏水基团，且所述相互作用均不包括带电团，即离子交换配体。该发明还包括一种分离介质，其包括将这种多模态配体固定到基质上。
• Process for the purification of antibodies
  申请人：Johansson Bo-Lennart

  公开号：US20070167613A1

  公开（公告）日：2007-07-19

  The present invention relates to a process for the purification of antibodies from one or more impurities in a liquid, which process comprises contacting said liquid with a first chromatography resin comprised of a support to which multi-modal ligands have been immobilised to adsorb the antibodies to the resin, wherein each multi-modal ligand comprises at least one cation-exchanging group and at least one aromatic or heteroaromatic ring system; adding an eluent to release the antibodies from the resin; and contacting the eluate so obtained with a second chromatography resin. In one embodiment, the ring-forming atoms of the aromatic or heteroaromatic entity are selected from the group consisting of C, S and O, and the cation exchanging group is a weak cation exchanger.

  本发明涉及一种从液体中纯化抗体并去除一种或多种杂质的方法，该方法包括将所述液体与第一色谱树脂接触，该色谱树脂由支持体和多模态配体组成，其中每个多模态配体包括至少一个阳离子交换基团和至少一个芳香或杂芳环系统，以吸附抗体到树脂上；加入洗脱剂以从树脂中释放抗体；并将所得的洗脱物与第二色谱树脂接触。在一种实施例中，芳香或杂芳实体的环形原子选择自C、S和O组成的群体，并且阳离子交换基团是弱阳离子交换剂。
• Synthesis of S-linked carbohydrate analogues via a Ferrier reaction
  作者：David Ellis、Sarah E. Norman、Helen M.I. Osborn

  DOI：10.1016/j.tet.2008.01.042

  日期：2008.3

  In this work, the synthetic utility of the Ferrier reaction to access S-linked disaccharides and S-linked glycoamino acids has been probed. Significantly, entry to a range of 1,4- and 1,6-S-linked disaccharides has been achieved using glycals derived from glucose and galactose, and sulfur containing coupling partners derived from methyl alpha-D-glucopyranoside. Access to S-linked glycoamino acids and glycopeptides has also been achieved using protected cysteine and homocysteine coupling partners within the Ferrier reaction. Functionalisation of the Ferrier products, for example, via dihydroxylation using OsO4 or amino acid coupling, and deprotection of the targets have also been achieved. In this way, entry to materials of interest as mimics of biologically interesting disaccharides and glycopeptides has been realised, including targets derived from rare sugars such as talopyranose and gulopyranose. (C) 2008 Elsevier Ltd. All rights reserved.
• A PROCESS FOR THE PURIFICATION OF ANTIBODIES
  申请人：GE Healthcare Bio-Sciences AB

  公开号：EP1718386A1

  公开（公告）日：2006-11-08
• US7750129B2
  申请人：——

  公开号：US7750129B2

  公开（公告）日：2010-07-06