2-methylpropane-1,1-diyl diacetate | 6283-77-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methylpropane-1,1-diyl diacetate
• 英文别名: 1,1-diacetoxy-2-methylpropane；isobutylidene diacetate；1,1-diacetoxy-2-methyl-propane；1,1-Diacetoxy-2-methyl-propan；1,1-Diacetoxy-2-methylprop-1-en；(1-acetyloxy-2-methylpropyl) acetate
• CAS: 6283-77-8
• 化学式: C₈H₁₄O₄
• 分子量: 174.197
• InChiKey: YZJNLSNJLRWSOW-UHFFFAOYSA-N

物化性质

• 沸点：
  180-185 °C(Press: 1.5 Torr)
• 密度：
  1.034±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methylpropane-1,1-diyl diacetate 在 水 作用下， 反应 0.33h， 以90%的产率得到异丁醛
  参考文献：
  名称：

  Green procedures for the chemoselective synthesis of acylals and their cleavage promoted by recoverable sulfonic acid based nanoporous carbon (CMK-5-SO3H)

  摘要：

  报道了一种在无溶剂反应条件下，使用可回收的纳米多孔固体磺酸（CMK-5-SO3H）作为催化剂，从醛和乙酸酐反应中选择性合成二乙酸酯的方法。研究发现，该催化剂对水中的所得乙缩醛脱保护反应也具有高度活性。

  DOI：

  10.1007/s12039-015-0884-0
• 作为产物：
  描述：

  异丁醛 以90%的产率得到
  参考文献：
  名称：

  Kumar Pradeep, Hegde Vishnumurthy R., Kumar T. Pavan, Tetrahedron Lett, 36 (1995) N 4, S 601-602

  摘要：

  DOI：

文献信息

• Zinc Tetrafluoroborate-Catalyzed Efficient Conversion of Aldehydes to Geminal Diacetates and Cyanoacetates
  作者：Brindaban C. Ranu、Jyotirmoy Dutta、Arijit Das

  DOI：10.1246/cl.2003.366

  日期：2003.4

  A trace of an aqueous solution of zinc tetrafluoroborate was demonstrated to catalyze the conversion of an aldehyde to its 1,1-diacetate by acetic anhydride without any solvent. A similar reaction of an aldehyde with a mixture of potassium cyanide and acetic anhydride in methylene chloride was also catalyzed by Zn(BF4)2 to provide the corresponding geminal cyanoacetate.

  演示了一种含锌四氟硼酸盐的水溶液在无任何溶剂的情况下催化醛向其1,1-二乙酸酯的转化，该转化是通过乙酸酐实现的。类似地，在二氯甲烷中，醛与氰化钾和乙酸酐的混合反应也受到Zn(BF₄)₂的催化，生成相应的乙二酸酯。
• Nickel boride mediated chemoselective deprotection of 1,1-diacetates to aldehydes and deprotection with concomitant reduction to alcohols at ambient temperature
  作者：Gaurav Bartwal、Mohit Saroha、Jitender M. Khurana

  DOI：10.1080/00397911.2017.1390687

  日期：2018.1.2

  aldehydes as well as deprotected and concomitantly reduced to the corresponding alcohols in high yields at ambient temperature with nickel boride generated in situ using different molar ratios of sodium borohydride and nickel (II) chloride in methanol at room temperature. Deprotection and reduction of a variety of aromatic, aliphatic and heterocyclic acylals have been achieved efficiently. Mild reaction conditions

  摘要 使用不同摩尔比的硼氢化钠和硼化镍原位生成硼化镍，多种 1,1-二乙酸盐已被化学选择性和有效地脱保护为相应的醛，并在环境温度下以高产率脱保护并伴随还原为相应的醇。室温下在甲醇中的氯化镍 (II)。已经有效地实现了各种芳香族、脂肪族和杂环酰基的脱保护和还原。温和的反应条件、易于处理、高产率和化学选择性证明了这种新方法的有效性。图形概要
• Microwave-assisted green synthesis of 1,1-diacetates (acylals) using selectfluor™ as an environmental-friendly catalyst under solvent-free conditions
  作者：Sobhan Rezayati、Rahimeh Hajinasiri、Zahra Erfani

  DOI：10.1007/s11164-015-2168-1

  日期：2016.3

  An efficient and simple procedure has been developed for the acetylation of aldehyde by selectfluor™ [1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2,2,2]octane bis(tetrafluoroborate)] as a chemoselective and environmentally friendly catalyst under solvent-free conditions or microwave irradiation. The application of microwave irradiation improved the yields and reduced the reaction times. In this study

  已开发出一种有效而简单的方法，可通过selectfluor™[1-（氯甲基）-4-氟-1,4-二氮杂双环[2,2,2]辛烷双（四氟硼酸酯）]进行乙酰化，对环境具有化学选择性。无溶剂条件下或微波辐射下作为友好催化剂。微波辐射的应用提高了收率并缩短了反应时间。在这项研究中，在酮存在下观察到醛的选择性转化，并且在回流条件下使用selectfluor™在水中作为绿色溶剂也实现了1,1-二乙酸酯的脱保护。该方法提供了微波辐射的协同作用，该协同作用具有几个优点，例如后处理简单，反应时间短，产率高以及对环境有益。
• SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS
  申请人：CONFLUENCE LIFE SCIENCES, INC.

  公开号：US20130143906A1

  公开（公告）日：2013-06-06

  The present disclosure provides pyrimidinone-phenyl-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and inflammatory disease, having the structure of Formula (I): wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.

  本公开提供了在治疗p38激酶介导的疾病（如淋巴瘤和炎症性疾病）中有用的嘧啶酮-苯基-嘧啶基化合物，其具有如下式（I）的结构： 其中R1、R2、R3、R4和R5如详细描述中所定义；包括至少一种该化合物的药物组合物；以及使用该化合物治疗p38激酶介导的疾病的方法。
• Silica Phosphoric Acid: An Efficient and Recyclable Catalyst for the Solvent-Free Synthesis of Acylals and Their Deprotection in MeOH
  作者：Fuyi Zhang、Hong Liu、Qing-Ju Zhang、Yu-Fen Zhao、Feng-Ling Yang

  DOI：10.1080/00397910903398650

  日期：2010.9.30

  Silica phosphoric acid was used as an efficient, mild, and recyclable solid catalyst for the synthesis of acylals from various structurally diverse aldehydes and acetic anhydride under solvent-free conditions. The acylation of aldehydes was highly chemoselective, and no ketone was acylated, which provided a method for the synthesis of acylals from aldehydes in the presence of ketones. Silica phosphoric

  二氧化硅磷酸被用作一种高效、温和且可回收的固体催化剂，用于在无溶剂条件下从各种结构不同的醛和乙酸酐合成酰基。醛的酰化具有很强的化学选择性，没有酮被酰化，这为在酮存在下由醛合成酰基提供了一种方法。二氧化硅磷酸催化脱保护酰基醛为甲醇中的相应醛类也已开发出优异的产率。芳香醛酰基的脱保护优先于脂肪醛的脱保护。