4-(3-(piperidin-1-yl)propoxy)benzoic acid hydrochloride | 685565-09-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-(piperidin-1-yl)propoxy)benzoic acid hydrochloride
• 英文别名: 4-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride；4-(3-piperidin-1-ylpropoxy)benzoic acid;hydrochloride
• CAS: 685565-09-7
• 化学式: C₁₅H₂₁NO₃*ClH
• 分子量: 299.798
• InChiKey: GTNXJNORCIPAAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.06
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(3-(piperidin-1-yl)propoxy)benzoic acid hydrochloride 以 氯化亚砜 为溶剂， 反应 1.0h， 以to give the title compound (D3) as a white powder (0.24 g)的产率得到4-(3-(piperidin-1-yl)propoxy)benzoyl chloride hydrochloride
  参考文献：
  名称：

  Bicyclic Benzamide Compoundssa as Histamine H3 Receptor Ligand Useful in the Treatment of Neurological Diseases

  摘要：

  本发明涉及具有药理活性的新型双环苯甲酰胺衍生物，其制备方法，包含它们的组合物以及它们在治疗神经和精神障碍方面的应用。

  公开号：

  US20070105838A1
• 作为产物：
  描述：

  1-(3-氯丙基)哌啶 单盐酸盐 在 potassium carbonate 、 potassium iodide 、 lithium hydroxide 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 反应 73.0h， 生成 4-(3-(piperidin-1-yl)propoxy)benzoic acid hydrochloride
  参考文献：
  名称：

  Bodilisant—A Novel Fluorescent, Highly Affine Histamine H₃ Receptor Ligand

  摘要：

  A piperidine-based lead structure for the human histamine H-3 receptor (hH(3)R) was coupled with the BODIPY fluorophore and resulted in a strong green fluorescent (quantum yield, 0.92) hH(3)R ligand with affinity in the nanomolar concentration range (K-i hH(3)R = 6.51 +/- 3.31 nM), named Bodilisant. Screening for affinities at histamine and dopamine receptor subtypes showed high hH(3)R preference. Bodilisant was used for visualization of hH(3)R in hH(3)R overexpressing HEK-293 cells with fluorescence confocal laser scanning microscopy. In addition, in native human brain tissues, Bodilisant showed clear and displaceable images of labeled hH(3)R.

  DOI：

  10.1021/ml300383n

文献信息

• [EN] BICYCLIC BENZAMIDE COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGAND USEFUL IN THE TREATMENT OF NEUROLOGICAL DISEASES<br/>[FR] COMPOSES BENZAMIDE BICYCLIQUES TENANT LIEU DE LIGANDS DU RECEPTEUR H3 DE L'HISTAMINE, UTILES DANS LE TRAITEMENT DES MALADIES NEUROLOGIQUES
  申请人：GLAXO GROUP LTD

  公开号：WO2004037788A1

  公开（公告）日：2004-05-06

  The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型双环苯甲酰胺衍生物，其制备方法，含有它们的组合物以及它们在治疗神经系统和精神疾病中的应用。
• [EN] ARYLOXYALKYLAMINE DERIVATES AS H3 RECEPTOR LIGANDS<br/>[FR] DERIVES D'ARYLOXYALKYLAMINE TELS QUE DES LIGANDS DU RECEPTEUR H3
  申请人：GLAXO GROUP LTD

  公开号：WO2004037800A1

  公开（公告）日：2004-05-06

  The present invention relates to novel benzyloxy derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型苄氧基衍生物，其制备方法，含有它们的组合物以及它们在治疗神经系统和精神疾病中的用途。
• Aryloxyalkylamine derivatives as h3 receptor ligands
  申请人：Best John Desmond

  公开号：US20060052597A1

  公开（公告）日：2006-03-09

  The present invention relates to novel benzyloxy derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型苯甲氧基衍生物，其制备过程，包含它们的组合物以及它们在治疗神经病学和精神病学疾病中的应用。
• Bicyclic Benzamide Compoundssa as Histamine H3 Receptor Ligand Useful in the Treatment of Neurological Diseases
  申请人：Best John Desmond

  公开号：US20070105838A1

  公开（公告）日：2007-05-10

  The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型双环苯甲酰胺衍生物，其制备方法，包含它们的组合物以及它们在治疗神经和精神障碍方面的应用。
• NOVEL COMPOUNDS
  申请人：Best Desmond John

  公开号：US20090042862A1

  公开（公告）日：2009-02-12

  The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型双环苯甲酰胺衍生物，其制备过程，包含它们的组合物以及它们在治疗神经系统和精神疾病方面的应用。