trimethylsulfonium iodide | 1030268-21-3

• 分子结构分类: 有机化合物 - 有机硫化合物
• 英文名称: trimethylsulfonium iodide
• 英文别名: trimethylsulfur iodide；Me₃SI；Iodo(trimethyl)-lambda4-sulfane；iodo(trimethyl)-λ4-sulfane
• CAS: 1030268-21-3
• 化学式: C₃H₉IS
• 分子量: 204.075
• InChiKey: SMZORVKKJCIPCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  trimethylsulfonium iodide 以96%的产率得到
  参考文献：
  名称：

  BORREDON, E.;DELMAS, M.;GASET, A., TETRAHEDRON LETT., 1982, 23, N 50, 5283-5286

  摘要：

  DOI：
• 作为产物：
  描述：

  thiiranemethanethiol 、 碘甲烷 生成 trimethylsulfonium iodide
  参考文献：
  名称：

  532.抗结核硫化合物。第二部分 衍生自二巯基链烷醇的某些环状硫化物

  摘要：

  DOI：

  10.1039/jr9600002660
• 作为试剂：
  描述：

  对氰基苯乙酮 在 盐酸 、 sodium hydroxide 、 trimethylsulfonium iodide 、 溴 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 、 二甲基亚砜 为溶剂， 反应 85.5h， 生成 2,4-bis(4-ethoxyiminoylphenyl)furan dihydrochloride
  参考文献：
  名称：

  2,4-Diphenyl Furan Diamidines as Novel Anti-Pneumocystis carinii Pneumonia Agents

  摘要：

  Dicationic 2,4-bis(4-amidinophenyl)furans 5-10 and 2,4-bis(4-amidinophenyl)-3,5-dimethylfurans 14 and 15 have been synthesized. Thermal melting studies revealed high binding affinity of the compounds to poly(dA-dT) and to the duplex oligomer d(CGCGAATTCGCG)(2). All of the new compounds were effective against Pneumocystis carinii pneumonia in the immunosuppressed rat model with up to 200-fold increase in activity compared to the control compound pentamidine. No toxicity was noted for 5, 7-10 at the dose of 10 mu mol/kg/d; however, the isopropyl analogue 7 showed toxicity comparable to pentamidine at the dosage of 20 mu mol/kg/d. Dimethylation of the parent compound on the furan ring resulted in reduced activity and increased toxicity.

  DOI：

  10.1021/jm990071c

文献信息

• [EN] C7 SUBSTITUTED OXYSTEROLS AND METHODS AS NMDA MODULATORS<br/>[FR] OXYSTÉROLS SUBSTITUÉS EN C7 ET PROCÉDÉS EN TANT QUE MODULATEURS NMDA
  申请人：SAGE THERAPEUTICS INC

  公开号：WO2018064649A1

  公开（公告）日：2018-04-05

  Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1A, R1B, n, R2A, R2B, R3, and R4 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

  根据公式(A)提供化合物：以及药用可接受的盐和药物组合物；其中R1A，R1B，n，R2A，R2B，R3和R4如本文所述定义。本发明的化合物被认为可用于预防治疗各种疾病。
• A Radical Cascade Enabling Collective Syntheses of Natural Products
  作者：Xiaobei Wang、Dongliang Xia、Wenfang Qin、Ruijie Zhou、Xiaohan Zhou、Qilong Zhou、Wentao Liu、Xiang Dai、Huijing Wang、Shuqing Wang、Ling Tan、Dan Zhang、Hao Song、Xiao-Yu Liu、Yong Qin

  DOI：10.1016/j.chempr.2017.04.007

  日期：2017.6

  Natural products have long been important inspirations for the development of chemical methodologies, theories, and technologies, and ultimately, discoveries of new drugs and materials. Chemical syntheses have traditionally yielded individual or small groups of natural products; however, methodology development allowing the synthesis of a large collection of natural products remains scarce. Here, we

  长期以来，天然产物一直是化学方法论，理论和技术发展以及最终发现新药物和新材料的重要灵感。传统上，化学合成产生单个或一小群天然产物。但是，仍然缺乏方法学的发展以允许合成大量天然产物。在这里，我们报告了一种有效的光催化自由基级联方法，该方法可以访问手性和多环稠合的四氢咔啉酮的文库。自由基级联可以可控制地将复杂性和功能性引入具有出色的化学选择性，区域选择性和非对映选择性的产品中。这种独特方法的强大功能已通过有效合成属于四个家族的33种单萜类吲哚生物碱得到了证明。
• Synthesis of bifunctionalized nitroxyls via intramolecular epoxide ring opening
  作者：Olga A Ozhogina

  DOI：10.1016/s0040-4039(01)02215-8

  日期：2002.1

  The syntheses of nitroxyl oxirane and further functionalized derivatives are described. Ring-cleavage reactions of this epoxide have been carried out with a variety of nucleophiles in order to show the general synthetic utility for preparing nitroxyls bearing two functional groups. The relatively facile synthesis of the nitroxyl amino alcohol should prove to be valuable in various spin labeling applications

  描述了硝酰基环氧乙烷和其他官能化衍生物的合成。为了显示用于制备带有两个官能团的硝酰基的一般合成用途，已经用多种亲核试剂进行了该环氧化物的环裂解反应。硝基氧基氨基醇的相对容易的合成应该在各种旋转标记应用中被证明是有价值的。
• Formation of Ketenimines via the Palladium-Catalyzed Decarboxylative π-Allylic Rearrangement of <i>N</i>-Alloc Ynamides
  作者：Juliana R. Alexander、Matthew J. Cook

  DOI：10.1021/acs.orglett.7b02780

  日期：2017.11.3

  A new approach for the formation of ketenimines via a decarboxylative allylic rearrangement pathway that does not require strong stabilizing or protecting groups has been developed. The products can be readily hydrolyzed into their corresponding secondary amides or reacted with sulfur ylides to perform an additional [2,3]-Wittig process. Mechanistic studies suggest an outer-sphere process in which

  已经开发了通过脱羧基的烯丙基重排途径形成酮亚胺的新方法，该方法不需要强的稳定基团或保护基团。产物可以容易地水解成它们相应的仲酰胺或与硫酰化物反应以进行另外的[2，3] -Wittig方法。机理研究表明，其中还原烷基化是限速的外球过程。
• Structural and Configurational Dependence of the Sensory Process in Steroids
  作者：G�nther Ohloff、Bruno Maurer、Beat Winter、Wolfgang Giersch

  DOI：10.1002/hlca.19830660121

  日期：1983.2.2

  19-nortestosterone have led to the synthesis of over 60 androstane and estrane derivatives whose sensory evaluation has allowed molecular parameters to be established for release of a ‘steroid-type’ scent. Odor perception with O-containing compounds in both classes has been found to be regioselective1. Osmophoric groups at C(3) were found to be the most active and specific. Functionality at C(2) is accompanied

  睾丸激素和19-去甲睾丸激素的结构修饰已导致合成了60多种雄甾烷和雌二醇衍生物，其感官评估已为释放“类固醇型”气味建立了分子参数。两种类别的含O化合物的气味感知都具有区域选择性1。C（3）处的渗透基团是最活跃和最特异的。C（2）处的功能在很大程度上伴随着原子缺陷，并且在特殊情况下，C（1）和C（4）处的含O取代基似乎会影响受体膜。