2,4-Dibrom-isopropylbenzol | 58683-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-Dibrom-isopropylbenzol
• 英文别名: 2,4-dibromo-1-isopropyl-benzene；2,4-Dibrom-1-isopropyl-benzol；2,4-Dibromo-1-isopropylbenzene；2,4-dibromo-1-propan-2-ylbenzene
• CAS: 58683-73-1
• 化学式: C₉H₁₀Br₂
• 分子量: 277.986
• InChiKey: CWZVGUOYTWYNJC-UHFFFAOYSA-N

物化性质

• 熔点：
  242-245 °C
• 沸点：
  274.6±20.0 °C(Predicted)
• 密度：
  1.6939 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,4-Dibrom-isopropylbenzol 在 硝酸 作用下， 生成 1,5-二溴-2,4-二硝基苯
  参考文献：
  名称：

  Qvist, Acta Academiae Aboensis, Series B: Mathematica et Physica, 1936, vol. 10, # 5, p. 3,27

  摘要：

  DOI：
• 作为产物：
  描述：

  异丙苯 在 碘 、 铁粉 作用下， 生成 2,4-Dibrom-isopropylbenzol 、 1,2-dibromo-4-isopropylbenzene
  参考文献：
  名称：

  Qvist, Acta Academiae Aboensis, Series B: Mathematica et Physica, 1936, vol. 10, # 5, p. 3,27

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED GEMCITABINE ARYL AMIDE ANALOGS<br/>[FR] ANALOGUES ARYLAMIDES SUBSTITUÉS DE GEMCITABINE
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2014074725A1

  公开（公告）日：2014-05-15

  In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating viral disorders and disorders of uncontrolled cellular proliferation using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及替代的吉西他滨芳基酰胺类似物，其衍生物和相关化合物；合成制备这些化合物的方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗病毒性疾病和细胞不受控制增殖的疾病的方法。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：EP3611165A1

  公开（公告）日：2020-02-19

  This is to provide a novel compound capable of treating or preventing plant diseases. The pyridone compounds of the present invention are novel compounds and can treat or prevent plant diseases.

  这是为了提供一种能够治疗或预防植物病害的新型化合物。 本发明的吡啶酮化合物属于新型化合物，可以治疗或预防植物病害。
• SUBSTITUTED GEMCITABINE ARYL AMIDE ANALOGS
  申请人：NUCORION PHARMACEUTICALS, INC.

  公开号：EP2916840B1

  公开（公告）日：2017-11-01
• CONTROL OF SUSTAINED CASING PRESSURE IN WELLBORE ANNULI
  申请人：Albemarle Corporation

  公开号：EP3087155A1

  公开（公告）日：2016-11-02
• INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20180105508A1

  公开（公告）日：2018-04-19

  The present invention provides compounds pounds of Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, pro-drugs, and compositions thereof. Also provided are methods and kits involving the compounds of Formula (I), (II) or (III) for treating diseases associated with the over-expression of phosphoglycerate dehydrogenase (PHGDH) in a subject, such as proliferative diseases (e.g., cancers (e.g., breast cancer, ER negative breast cancer, melanoma, cervical cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases). Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the activity of PHGDH or inhibit the serine biosynthetic pathway, or both.