Morphine oleate | 6033-05-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: Morphine oleate
• 英文别名: (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;(Z)-octadec-9-enoic acid
• CAS: 6033-05-2
• 化学式: C35H53NO5
• 分子量: 567.8
• InChiKey: KPSMEDRDTQAZOY-QWJUXTQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.31
• 重原子数：
  41
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  90.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Methods and compositions for reducing the development of drug tolerance and/or physical dependence
  申请人：The Regents of the University of California

  公开号：US20040024005A1

  公开（公告）日：2004-02-05

  The present invention provides methods for reducing, preventing or delaying the development of tolerance to certain drugs that target G-protein coupled receptors (GPCR). The methods are generally carried out by co-administering with the drug an agonist for the drug-target GPCR that promotes the endocytosis of the targetted receptor. The methods are particularly useful for drugs that target the opioid receptors, for example morphine. The present invention also provides compositions comprising a drug and an agonist that are advantageous in preventing the development of tolerance to the drug that can develop when the drug is administered alone.

  本发明提供了减少、预防或延缓对某些靶向 G 蛋白偶联受体（GPCR）的药物产生耐受性的方法。这些方法通常是通过与药物共同施用促进靶向受体内吞的药物靶 GPCR 激动剂来实现的。这些方法尤其适用于靶向阿片受体的药物，例如吗啡。本发明还提供了由药物和激动剂组成的组合物，这种组合物在防止对药物产生耐受性方面具有优势，因为在单独给药时可能会产生耐受性。
• Dynorphin amide analogs
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP0096592B1

  公开（公告）日：1986-09-24
• OLIGONUCLEOTIDE SEQUENCES AND TRANSGENIC ANIMALS TRANSFECTED THEREWITH HAVING REDUCED SENSITIVITY TO NARCOTIC ANALGESICS
  申请人：DUZ PARTNERSHIP

  公开号：EP0643768A1

  公开（公告）日：1995-03-22
• DES-TYR DYNORPHIN ANALOGUES
  申请人：DES-TYR DYNORPHIN PARTNERSHIP

  公开号：EP0652765A1

  公开（公告）日：1995-05-17
• EP0652765A4
  申请人：——

  公开号：EP0652765A4

  公开（公告）日：1997-04-09