(E)-1-methoxy-2-phenylbutene | 141739-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-methoxy-2-phenylbutene
• 英文别名: (E)-1-methoxy-2-phenyl-1-butene；[(E)-1-methoxybut-1-en-2-yl]benzene
• CAS: 141739-70-0
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: NHPUVJVMZGEGAU-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-1-bromo-2-phenyl-1-butene 、 sodium methylate 在 甲醇 、 copper(I) bromide 作用下， 反应 1.0h， 以85%的产率得到(E)-1-methoxy-2-phenylbutene
  参考文献：
  名称：

  铜催化从未活化的乙烯基卤化物制备乙烯基醚

  摘要：

  乙烯基卤化物已在10摩尔％的溴化铜存在下用甲醇钠处理过。因此，可以高收率获得大多数乙烯基甲基醚。反应以100％保留构型进行。简短地讨论了该过程的机制。

  DOI：

  10.1016/s0040-4020(01)88528-8

文献信息

• [EN] AGONISTS OF GPR40<br/>[FR] AGONISTES DE GPR40
  申请人：CONNEXIOS LIFE SCIENCES PVT LTD

  公开号：WO2012011125A1

  公开（公告）日：2012-01-26

  The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are therefore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders related to GPR40 activity.

  本发明涉及具有调节GPR40活性能力的化合物，因此在治疗与GPR40相关的疾病方面具有用处。此外，该发明涉及这些化合物、其制备方法、含有这些化合物的药物组合物以及在治疗与GPR40活性相关的某些疾病方面使用这些化合物的用途。
• A Simple Primary Amine Catalyst for Enantioselective α-Hydroxylations and α-Fluorinations of Branched Aldehydes
  作者：Michael R. Witten、Eric N. Jacobsen

  DOI：10.1021/acs.orglett.5b01193

  日期：2015.6.5

  A new primary amine catalyst for the asymmetric a-hydroxylation and a-fluorination of alpha-branched aldehydes is described. The products of the title transformations are generated in excellent yields with high enantioselectivities. Both processes can be performed within short reaction times and on gram scale. The similarity in results obtained in both reactions, combined with computational evidence, implies a common basis for stereoinduction and the possibility of a general catalytic mechanism for a-functionalizations. Promising initial results in alpha-amination and alpha-chlorination reactions support this hypothesis.
• Copper catalysed preparation of vinyl ethers from unactivated vinylic halides
  作者：Menno A. Keegstra

  DOI：10.1016/s0040-4020(01)88528-8

  日期：1992.3

  Vinylic halides have been treated with sodium methoxide in the presence of 10 mol% of copper bromide. Most of the vinylic methyl ethers could thus be obtained in a good yield. The reaction proceeds with a 100% retention of configuration. The mechanism of the process is shortly discussed.

  乙烯基卤化物已在10摩尔％的溴化铜存在下用甲醇钠处理过。因此，可以高收率获得大多数乙烯基甲基醚。反应以100％保留构型进行。简短地讨论了该过程的机制。