ethyl N-[2-(2-methoxyphenoxy)ethyl]carbamate | 1218777-36-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ethyl N-[2-(2-methoxyphenoxy)ethyl]carbamate
• CAS: 1218777-36-6
• 化学式: C₁₂H₁₇NO₄
• 分子量: 239.271
• InChiKey: HVUGQXKHENDVOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  potassium cyanate 、 乙醇 、 愈创木酚 2-氯乙基醚 在 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以78%的产率得到ethyl N-[2-(2-methoxyphenoxy)ethyl]carbamate
  参考文献：
  名称：

  DMAP-catalyzed synthesis of 2-oxazolidinones from corresponding halohydrins using KOCN/DMF

  摘要：

  We report facile and simple synthesis of a variety of 2-oxazolidinones from the corresponding halohydrins by reaction with KOCN in DMF catalyzed by DMAP. DMAP and temperature play key roles in enriching the yield of 2-oxazolidinones. A few examples in this Letter are applicable to pharmaceutically important processes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.115

文献信息

• DMAP-catalyzed synthesis of 2-oxazolidinones from corresponding halohydrins using KOCN/DMF
  作者：K. Chinnam Naidu、G. Ravi Babu、L. Gangaiah、K. Mukkanti、G. Madhusudhan

  DOI：10.1016/j.tetlet.2009.12.115

  日期：2010.2

  We report facile and simple synthesis of a variety of 2-oxazolidinones from the corresponding halohydrins by reaction with KOCN in DMF catalyzed by DMAP. DMAP and temperature play key roles in enriching the yield of 2-oxazolidinones. A few examples in this Letter are applicable to pharmaceutically important processes. (C) 2009 Elsevier Ltd. All rights reserved.