(2-nitrophenyl) (pentyl) sulfane | 76697-40-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-nitrophenyl) (pentyl) sulfane
• 英文别名: o-nitrophenyl pentyl sulfide；2-Nitrophenyl-pentyl-sulfid；(2-nitrophenyl)thiopentane；(2-nitro-phenyl)-pentyl sulfide；(2-Nitro-phenyl)-pentyl-sulfid；1-Nitro-2-pentylsulfanylbenzene
• CAS: 76697-40-0
• 化学式: C₁₁H₁₅NO₂S
• 分子量: 225.312
• InChiKey: AISASUOKIFASEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-nitrophenyl) (pentyl) sulfane 在 乙醇 、 镍 作用下， 生成 2-aminophenyl pentyl sulphide
  参考文献：
  名称：

  Gialdi; Baruffini, Farmaco, Edizione Scientifica, 1957, vol. 12, p. 206,212

  摘要：

  DOI：
• 作为产物：
  描述：

  2-硝基碘苯 在 copper(I) oxide 、 potassium hydroxide 作用下， 以 水 为溶剂， 反应 48.0h， 生成 (2-nitrophenyl) (pentyl) sulfane
  参考文献：
  名称：

  Ligand-Free Copper-Catalyzed Synthesis of Asymmetrical Thioethers by Coupling Aryl or Alkyl Halides Using an Acetyl Thiourea Precursor in Wet Polyethylene Glyol (PEG 400)

  摘要：

  Asymmetrical diaryl or aryl alkyl thioethers can be prepared in good to excellent yields by coupling the appropriate aryl iodides and aryl or alkyl bromines using acetyl thiourea as a thiolprecursor, Cu2O as a catalyst, KOH as a base, and PEG 400-H2O as a solvent under ligand-free conditions.

  DOI：

  10.1080/10426507.2014.906428

文献信息

• Air-stable binuclear Titanium(IV) salophen perfluorobutanesulfonate with zinc power catalytic system and its application to C–S and C–Se bond formation
  作者：Lingxiao Wang、Jie Qiao、Jiancong Wei、Zhiwu Liang、Xinhua Xu、Ningbo Li

  DOI：10.1016/j.tet.2019.130750

  日期：2020.1

  An air-stable μ-oxo-bridged binuclear Lewis acid of titanium(IV) salophen perfluorooctanesulfonate [Ti(salophen)H2O}2O][OSO2C4F9]2 (1) was successfully synthesized by the reaction of TiIV(salophen)Cl2 with AgOSO2C4F9 and characterized by techniques such as IR, NMR and HRMS. This complex was stable open to air over a year, and exhibited good thermal stability and high solubility in polar organic solvents

  通过反应成功合成了稳定的空气稳定的μ-氧桥双核路易斯酸钛（IV）Salophen全氟辛烷磺酸[Ti（salophen）H 2 O} 2 O] [OSO 2 C 4 F 9 ] 2（1）。AgOSO 2 C 4 F 9制备Ti IV（盐基）Cl 2并通过IR，NMR和HRMS等技术进行表征。该复合物可在一年中稳定地暴露于空气中，并具有良好的热稳定性和在极性有机溶剂中的高溶解度。该配合物还具有相对较强的酸度，强度为0.8
• Efficient CS Cross-Coupling of Thiols with Aryl Iodides Catalyzed by Cu(OAc)₂·H₂O and 2,2′-Biimidazole
  作者：Chenglong Zong、Jianli Liu、Shengyan Chen、Runsheng Zeng、Jianping Zou

  DOI：10.1002/cjoc.201300830

  日期：2014.3

  The classical Ullmann CS cross coupling reaction of aryl iodides with aromatic/alkyl thiols under catalysis of 15 mol% Cu(OAc)2·H2O and 15 mol% 2,2′‐biimidazole works at 80°C in DMSO for 3 h to provide a variety of aryl sulfides in good to excellent yields.

  经典的乌尔曼Ç  S的交叉偶联反应芳基碘与芳族/烷基硫醇在15％（摩尔）的Cu（OAc）的催化2 ·H 2在80℃下O和15摩尔％的2,2'-联咪唑作品在DMSO为3小时后即可提供各种芳基硫化物，收率好至极好。
• Notizen zur Synthese von 2-Aminophenylsulfonen
  作者：Alfred Courtin、Hans-Rudolf von Tobel、G�nther Auerbach

  DOI：10.1002/hlca.19800630610

  日期：1980.9.17

  Syntheses of some Alkyl, Cycloalkyl and Aryl 2-Aminophenyl Sulfones

  某些烷基，环烷基和芳基2-氨基苯基砜的合成
• Aryl carbonyl derivatives as therapeutic agents
  申请人：——

  公开号：US20040122235A1

  公开（公告）日：2004-06-24

  This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

  本发明涉及芳基羰基衍生物，其是葡萄糖激酶的激活剂，可用于管理、治疗、控制或辅助治疗增加葡萄糖激酶活性有益的疾病。
• ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS
  申请人：Polisetti Dharma Rao

  公开号：US20110301158A1

  公开（公告）日：2011-12-08

  This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

  本发明涉及芳基羰基衍生物，它们是葡萄糖激酶的活化剂，可能有助于管理、治疗、控制或辅助治疗增加葡萄糖激酶活性有益的疾病。