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3-methoxy-2-methylbenzenethiol | 854016-09-4

中文名称
——
中文别名
——
英文名称
3-methoxy-2-methylbenzenethiol
英文别名
6-methoxy-2-mercapto-toluene;Methyl-(3-mercapto-2-methyl-phenyl)-aether;3-Methoxy-2-methyl-phenylmercaptan;6-Methoxy-2-mercapto-toluol
3-methoxy-2-methylbenzenethiol化学式
CAS
854016-09-4
化学式
C8H10OS
mdl
——
分子量
154.233
InChiKey
PSHGYSFLYYILEN-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    238 °C
  • 密度:
    1.083±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    3
  • 重原子数:
    10
  • 可旋转键数:
    1
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    10.2
  • 氢给体数:
    1
  • 氢受体数:
    2

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    3-methoxy-2-methylbenzenethiol 在 aluminum (III) chloride 、 甲烷磺酸potassium carbonate十二硫醇 作用下, 以 N,N-二甲基甲酰胺甲苯 为溶剂, 反应 15.25h, 生成 methyl (6-hydroxy-7-methyl-1-benzothiophen-3-yl)acetate
    参考文献:
    名称:
    [EN] AROMATIC RING COMPOUND
    [FR] COMPOSÉ À NOYAU AROMATIQUE
    摘要:
    本发明提供了一种具有GOAT抑制作用的化合物,该化合物用于预防或治疗肥胖等疾病,并具有优异的疗效。本发明的化合物由式(I)表示:其中每个符号如说明书中所定义,或其盐。
    公开号:
    WO2013125732A1
  • 作为产物:
    描述:
    alkaline earth salt of/the/ methylsulfuric acid 在 盐酸tin 作用下, 生成 3-methoxy-2-methylbenzenethiol
    参考文献:
    名称:
    321.硫醇衍生自ø - ,米- ,和p -甲氧基甲苯和苯甲酸
    摘要:
    DOI:
    10.1039/jr9330001375
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文献信息

  • [EN] (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF<br/>[FR] TRANS-ISOMERES (+) DE DERIVES DE NUCLEOSIDE ( 1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL)METHYLE, PROCESSUS DE PREPARATION DE STEREO-ISOMERES DE CEUX-CI ET UTILISATION D'AGENTS ANTIVIRAUX A BASE CEUX-CI
    申请人:LG LIFE SCIENCES LTD
    公开号:WO2004029064A1
    公开(公告)日:2004-04-08
    The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.
    本发明涉及公式(1)的(+)-反式异构体(1-磷酸甲氧基-2-烷基环丙基)甲基核苷衍生物,该衍生物可用作抗病毒剂(特别是对乙型肝炎病毒),其药用盐、水合物或溶剂化合物,以及用于制备公式(1)化合物的立体异构体的方法,以及一种用于治疗病毒性疾病(特别是对乙型肝炎病毒)的组合物,包括公式(1)化合物的(+)-反式异构体,其药用盐、水合物或溶剂化合物作为活性物质。
  • Isoxazole derivatives as peroxisome proliferator-activated receptors agonists
    申请人:Fukui Yoshikazu
    公开号:US20070054902A1
    公开(公告)日:2007-03-08
    A compound of formula (I): (wherein R 1 -R 10 are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X 1 is —O—, —S—, —NR 11 — (wherein R 11 is hydrogen, lower alkyl or the like), —CR 12 R 13 CO—, —(CR 12 R 13 )mO—, —O(CR 12 R 13 )m- (wherein R 12 and R 13 are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like, X 2 is a bond, —O—, —S—, —NR 14 — (wherein R 14 is hydrogen, lower alkyl or the like, R 14 and R 6 can be taken together with the neighboring atom to form a ring) or —CR 15 R 16 — (wherein R 15 and R 16 are each independently hydrogen or lower alkyl, R 15 and R 6 or R 10 can be taken together with the neighboring carbon atom to form a ring, R 16 and R 9 can be joined together to form a bond), X 3 is COOR 17 , C(═NR 17 )NR 18 OR 19 or the like), a pharmaceutically acceptable salt or a solvate thereof.
    化合物的化学式为(I):(其中R1-R10各自独立地为氢,卤素,可选择性取代的低碳基或类似物,X1为—O—,—S—,—NR11—(其中R11为氢,低碳基或类似物),—CR12R13CO—,—(CR12R13)mO—,—O(CR12R13)m-(其中R12和R13各自独立地为氢或低碳基,m为1到3之间的整数)或类似物,X2为键,—O—,—S—,—NR14—(其中R14为氢,低碳基或类似物,R14和R6可以与相邻的原子结合形成环)或—CR15R16—(其中R15和R16各自独立地为氢或低碳基,R15和R6或R10可以与相邻的碳原子结合形成环,R16和R9可以结合在一起形成键),X3为COOR17,C(═NR17)NR18OR19或类似物),其药学上可接受的盐或溶剂化物。
  • AROMATIC RING COMPOUND
    申请人:TAKEDA PHARMACEUTICAL COMPANY LIMITED
    公开号:US20150018547A1
    公开(公告)日:2015-01-15
    The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
    本发明提供了一种具有GOAT抑制作用的化合物,该化合物可用于预防或治疗肥胖等疾病,并具有优越的疗效。该化合物由式(I)表示,其中每个符号如规范中所定义,或其盐。
  • Aromatic ring compound
    申请人:TAKEDA PHARMACEUTICAL COMPANY LIMITED
    公开号:US09238639B2
    公开(公告)日:2016-01-19
    The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
    本发明提供一种具有GOAT抑制作用的化合物,可用于预防或治疗肥胖等疾病,并具有优异的功效。本发明是由式(I)表示的化合物:其中每个符号如规范中所定义,或其盐。
  • A process for preparing a polyarylene thioether
    申请人:IDEMITSU PETROCHEMICAL CO. LTD.
    公开号:EP0281036A2
    公开(公告)日:1988-09-07
    A process for preparing a polyarylene thioether, which comprises polymerizing a thiophenol having the formula (I) and/or a diphenyldisulfide having the formula (II) wherein R are substituents selected from the group consisting of hydrogen atoms, lower alkyl groups, halogen atoms and lower alkoxy, the groups R may be different from or identical with each other, in the presence of a Lewis acid as a catalyst.
    一种制备聚芳基硫醚的工艺,包括在路易斯酸作为催化剂的存在下,聚合具有式(I)的噻吩酚和/或具有式(II)的二苯基二硫醚,其中 R 是选自氢原子、低级烷基、卤素原子和低级烷氧基组成的组的取代基,基团 R 可以彼此不同或相同。
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