2-(4-trifluoromethoxyanilino)-3-buten-1-ol | 1446417-58-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-trifluoromethoxyanilino)-3-buten-1-ol
• 英文别名: 2-[4-(Trifluoromethoxy)anilino]but-3-en-1-ol；2-[4-(trifluoromethoxy)anilino]but-3-en-1-ol
• CAS: 1446417-58-8
• 化学式: C₁₁H₁₂F₃NO₂
• 分子量: 247.217
• InChiKey: VDTOUCOMWUJCFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,5-二氢呋喃 、 对三氟甲氧基苯胺 在 zinc trifluoromethanesulfonate 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以63%的产率得到2-(4-trifluoromethoxyanilino)-3-buten-1-ol
  参考文献：
  名称：

  Zn(CF3SO3)2—mediated domino hydroamination-ring cleavage of 2,5-dihydrofuran

  摘要：

  By using Zn(CF3SO3)(2) as the catalyst, series of 2-arylamino-3-buten-1-ols (3) were successfully synthesized via domino hydroamination-ring cleavage of 2,5-dihydrofuran (1) with aromatic amines (2). A proton-induced and Zn(CF3SO3)(2)-assisted mechanism is proposed on the experimental basis, during which the proton is generated by the interaction between aniline and Zn(CF3SO3)(2). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.058

文献信息

• Zn(CF3SO3)2—mediated domino hydroamination-ring cleavage of 2,5-dihydrofuran
  作者：Xiao-juan Shen、Hong-zhong Bu、Jie Shi、Zheng-guang Wu、Hong-fei Ma、Yu-feng Li

  DOI：10.1016/j.tetlet.2013.05.058

  日期：2013.7

  By using Zn(CF3SO3)(2) as the catalyst, series of 2-arylamino-3-buten-1-ols (3) were successfully synthesized via domino hydroamination-ring cleavage of 2,5-dihydrofuran (1) with aromatic amines (2). A proton-induced and Zn(CF3SO3)(2)-assisted mechanism is proposed on the experimental basis, during which the proton is generated by the interaction between aniline and Zn(CF3SO3)(2). (C) 2013 Elsevier Ltd. All rights reserved.