Ethyl (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3`-METHYL-aminomethylbiphenyl-4-yl) propionate | 692258-15-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethyl (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3`-METHYL-aminomethylbiphenyl-4-yl) propionate
• 英文别名: ethyl (S)-2-tert-butoxycarbonylamino-3-(3'-methylaminomethylbiphenyl-4-yl)propionate；ethyl (2S)-3-[4-[3-(methylaminomethyl)phenyl]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 692258-15-4
• 化学式: C₂₄H₃₂N₂O₄
• 分子量: 412.529
• InChiKey: NBLKAVVMSVAQSC-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethyl (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3`-METHYL-aminomethylbiphenyl-4-yl) propionate 、 苯甲酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以64%的产率得到Ethyl (S)-3-{3`-[ (BENZOYLMETHYLAMINO) METHYL]-BIPHENYL-4-YL}-2-TERT-BUTOXYCARBONYLAMINOPROPIONATE
  参考文献：
  名称：

  [EN] BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  [FR] NOUVEAUX COMPOSES BIAROMATIQUES QUI ACTIVENT LES RECEPTEURS TYPE PPAR DOLLAR G(G), ET LEUR UTILISATION DANS LES COMPOSITIONS COSMETIQUES ET PHARMACEUTIQUES

  摘要：

  公开号：

  WO2004046091A3
• 作为产物：
  描述：

  Ethyl (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3`-FORMYL-biphenyl-4-yl) propionate 、 盐酸甲胺 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 16.5h， 以38%的产率得到Ethyl (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3`-METHYL-aminomethylbiphenyl-4-yl) propionate
  参考文献：
  名称：

  [EN] BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  [FR] NOUVEAUX COMPOSES BIAROMATIQUES QUI ACTIVENT LES RECEPTEURS TYPE PPAR DOLLAR G(G), ET LEUR UTILISATION DANS LES COMPOSITIONS COSMETIQUES ET PHARMACEUTIQUES

  摘要：

  公开号：

  WO2004046091A3

文献信息

• Novel biaromatic compounds which activate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20050256116A1

  公开（公告）日：2005-11-17

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有下列结构式（I）的新型双芳香化合物被用于制备适用于人类或兽医药学（在皮肤科、心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者制备化妆品组合物。
• NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE PPARY TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF
  申请人：CLARY LAURENCE

  公开号：US20090062340A1

  公开（公告）日：2009-03-05

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香族化合物被制成适合于在人类或兽医学中（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域中）进行治疗的制药组合物，或者制成化妆品组合物。
• Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Galderma Research & Development

  公开号：US07452878B2

  公开（公告）日：2008-11-18

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香族化合物制成适用于人类或兽医药学（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域），或者制成化妆品组成物。
• BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1575911A2

  公开（公告）日：2005-09-21
• [EN] NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE PPARgamma TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS<br/>[FR] NOUVEAUX COMPOSES BIAROMATIQUES QUI ACTIVENT LES RECEPTEURS TYPE PPAR DOLLAR G(G), ET LEUR UTILISATION DANS LES COMPOSITIONS COSMETIQUES ET PHARMACEUTIQUES
  申请人：GALDERMA RES & DEV

  公开号：WO2004046091A2

  公开（公告）日：2004-06-03

  The invention relates to novel biaromatic compounds which correspond to the general formula (I), and also to a process for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or alternatively in cosmetic compositions.