bis(2-hydroxy-4-methylphenyl)methanone | 24018-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(2-hydroxy-4-methylphenyl)methanone
• CAS: 24018-76-6
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: KMOXAYBUHOEDOC-UHFFFAOYSA-N

物化性质

• 沸点：
  392.3±37.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis(2-hydroxy-4-methylphenyl)methanone 在 (5aR,10bS)-2-mesityl-5a,10b-dihydro-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 39.0h， 生成 (M,S)-7-butyl-3,11-dimethyl-7,8-dihydro-6H-benzo[2,3]oxocino[5,4-b]benzofuran-6-one
  参考文献：
  名称：

  Diastereo- and Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade

  摘要：

  We present herein an unprecedented stereoselective synthesis of bridged biaryls with defined axial and central chirality from readily available starting materials. This N-heterocyclic carbene-catalyzed method proceeds through propargylic substitution of azolium enolates followed by two-directional cyclization, as supported by DFT calculation. A range of benzofuran/indole-derived bridged biaryls bearing an eight-membered lactone are accessed with uniformly high stereoselectivity (>98:2 dr, mostly >98% ee).

  DOI：

  10.1021/jacs.9b08510
• 作为产物：
  描述：

  间甲基苯甲醚 在 正丁基锂 、 三溴化硼 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 正戊烷 为溶剂， 反应 36.0h， 生成 bis(2-hydroxy-4-methylphenyl)methanone
  参考文献：
  名称：

  Diastereo- and Atroposelective Synthesis of Bridged Biaryls Bearing an Eight-Membered Lactone through an Organocatalytic Cascade

  摘要：

  We present herein an unprecedented stereoselective synthesis of bridged biaryls with defined axial and central chirality from readily available starting materials. This N-heterocyclic carbene-catalyzed method proceeds through propargylic substitution of azolium enolates followed by two-directional cyclization, as supported by DFT calculation. A range of benzofuran/indole-derived bridged biaryls bearing an eight-membered lactone are accessed with uniformly high stereoselectivity (>98:2 dr, mostly >98% ee).

  DOI：

  10.1021/jacs.9b08510

文献信息

• Broadening the catalyst and reaction scope of regio- and chemoselective C–H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(ii) and Ru(ii) catalysis
  作者：Gang Shan、Xuesong Han、Yun Lin、Shanyou Yu、Yu Rao

  DOI：10.1039/c3ob27457h

  日期：——

  catalyzed C–H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by gram-scale synthesis of a few different 2-acylphenols. Its utility has been well exemplified

  已开发出一种独特的Rh（II）和Ru（II）催化的芳基酮和其他芳烃的CH氧化反应，可以轻松合成各种功能化的酚。该反应显示出优异的反应性，区域和化学选择性，良好的官能团相容性和高产率。该方法的实用性已通过克级合成几种不同的2-酰基酚得到了证明。它的效用已在杂环合成和药物的直接修饰中的进一步应用中得到很好的例证非诺贝特。
• Synthesis of V‐Shaped Bis‐coumarins through Aldol Reaction/Double Lactonization Cascade Reaction from Bis(2‐hydroxyphenyl)methanone and Meldrum's Acid
  作者：Ding Wang、Zhishuang Ma、Jin Xi、Nana Wang、Tao Wang、Yong Liang、Zunting Zhang

  DOI：10.1002/ejoc.202101489

  日期：2022.4.5

  A concise and efficient method was developed for the synthesis of chromeno[3,4- c ]chromene-6,7-dione using readily available bis(2-hydroxyphenyl)methanone and Meldrum's acid. The protocol displays a broad substrate scope and good functional group tolerance, including alkyl, alkoxyl, aryl and halogens. These π-extended scaffolds showed blue-green fluorescence with a large Stokes shift. The photophysical

  使用容易获得的双（2-羟基苯基）甲酮和 Meldrum 酸，开发了一种用于合成色烯[3,4-c]色烯-6,7-二酮的简洁有效的方法。该协议显示了广泛的底物范围和良好的官能团耐受性，包括烷基、烷氧基、芳基和卤素。这些 π 延伸的支架显示出具有大斯托克斯位移的蓝绿色荧光。光物理研究表明，2 位取代的色烯[3,4-c]色烯-6,7-二酮引起了显着的红移。
• Cellulose Acylate Film, Method of Producing the Same, Cellulose Derivative Film, Optically Compensatory Film Using the Same, Optically-Compensatory Film Incorporating Polarizing Plate, Polarizing Plate and Liquid Crystal Display Device
  申请人：Haruta Hiromoto

  公开号：US20090290100A1

  公开（公告）日：2009-11-26

  A method of producing a cellulose derivative film, the method comprising: forming a film with a solvent cast method from a dope including a cellulose derivative satisfying following conditions (a) and (b): (a) at least one among three hydroxyl groups included in a glucose unit of cellulose is substituted by a substituent of which a polarizability anisotropy Δα represented as following Expression (1) is 2.5×10 −24 cm 3 or higher: Expression (1): Δα=αx−(αy+αz)/2, wherein αx, αy and αz is as defined in the specification; and (b) when a substitution degree by a substituent of which Δα is 2.5×10 −24 cm 3 or higher is P A , and a substitution degree by a substituent of which Δα is lower than 2.5×10 −24 cm 3 is P B , the P A and P B satisfy following Expressions (3) and (4): Expression (3): 2P A +P B >3.0; and Expression (4): P A >0.2.

  一种生产纤维素衍生物薄膜的方法，该方法包括：使用包括满足以下条件（a）和（b）的纤维素衍生物的溶胶，通过溶剂浇铸法形成薄膜：（a）纤维素的葡萄糖单元中的三个羟基中的至少一个被取代为极化率各向异性Δα（以下表达式（1）表示）为2.5×10-24cm3或更高的取代基：表达式（1）：Δα=αx-（αy+αz）/ 2，其中αx，αy和αz如规范中定义的；并且（b）当Δα为2.5×10-24cm3或更高的取代基的取代度为PA时，Δα低于2.5×10-24cm3的取代基的取代度为PB，PA和PB满足以下表达式（3）和（4）：表达式（3）：2PA + PB> 3.0；表达式（4）：PA> 0.2。
• Flame retarding resin composition
  申请人：——

  公开号：US20040077821A1

  公开（公告）日：2004-04-22

  Disclosed is a flame retarding resin composition comprising (A) one or more epoxy resins; (B) a hardener; and (C) a hardening accelerator, wherein the hardener of the component B is a phosphorus-containing compound represented by the following formula (I): 1 wherein each symbol is as defined below. The flame retarding resin composition of the present invention without adding halogen or other flame retardants has high flame retardancy and excellent heat resistance. The flame retarding resin composition of the present invention is suitably useful in the application of thermosetting resins, thermoplastic resins, bonding sheets, composite materials, laminated plates, printed circuit boards, copper foil adhesives, inks used for build-up process, semiconductor molding materials and the like.

  本发明公开了一种阻燃树脂组合物，该组合物包含(A)一种或多种环氧树脂；(B)一种固化剂；以及(C)一种硬化促进剂，其中成分 B 的固化剂是由下式(I)表示的含磷化合物： 1 其中各符号定义如下。本发明的阻燃树脂组合物不添加卤素或其他阻燃剂，具有高阻燃性和优异的耐热性。本发明的阻燃树脂组合物适用于热固性树脂、热塑性树脂、粘合片、复合材料、层压板、印刷电路板、铜箔粘合剂、用于堆积工艺的油墨、半导体成型材料等。
• Cosmetic composition
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20040219115A1

  公开（公告）日：2004-11-04

  A skin lightening composition comprising; a) 0.05 to 10% by weight of one of more of vitamin B3 compounds or its derivatives thereof; b) 0.01 to 10% by weight of allantoin; and c) a cosmetically acceptable vehicle or 15% to 85% by weight detergent active.

  一种皮肤美白组合物，包括 a) 0.05 至 10%（按重量计）的一种或多种维生素 B3 化合物或其衍生物； b) 0.01 至 10%（按重量计）尿囊素；以及 c) 化妆品可接受的载体或 15%至 85%（重量）的活性洗涤剂。