The invention is drawn to cholesterol derivatives in which a cyclopentane ring has been introduced onto the 25-carbon of the side chain and to 24-epimers of these compounds. The compounds are useful intermediates in the production of 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27-dimethylene-24-epi-1.alpha.,25-dihydroxyvitamin D.sub.2. These vitamin D derivatives are useful for the treatment of diseases such as osteoporosis.
本发明涉及
胆固醇衍
生物,其中在侧链的25-碳上引入了
环戊烷环,并且涉及这些化合物的24-表异构体。这些化合物是生产26,27-二甲基烷基-1α,25-二羟基
维生素D2和26,27-二甲基烷基-24-表异构体-1α,25-二羟基
维生素D2的有用中间体。这些
维生素D衍
生物对于治疗骨质疏松等疾病是有用的。