1,1-bis(4-methoxyphenyl)propanol | 384842-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-bis(4-methoxyphenyl)propanol
• 英文别名: 1,1-bis(4-methoxyphenyl)propan-1-ol
• CAS: 384842-35-7
• 化学式: C₁₇H₂₀O₃
• 分子量: 272.344
• InChiKey: IFVBBEQHGYMAPC-UHFFFAOYSA-N

物化性质

• 沸点：
  130 °C(Press: 0.05 Torr)
• 密度：
  1.097±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-bis(4-methoxyphenyl)propanol 在 对甲苯磺酸一水合物 作用下， 以 甲苯 为溶剂， 以2.60 g (97%)的产率得到1,1-bis(4-methoxyphenyl)propene
  参考文献：
  名称：

  2,2 (Diarlyl) Vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst

  摘要：

  一种由以下通用公式（1）表示的新型2,2-(二芳基)乙烯膦化合物：其中R1是氢原子、具有1至6个碳原子的烷基基团、具有5至7个碳原子的脂环基团等；R2、R3、R4、R5、R6和R7可能相同或不同，每个是具有1至6个碳原子的烷基基团、具有5至7个碳原子的脂环基团等，但要求R4和R5一起和/或R6和R7一起可能代表融合苯环、取代融合苯环、三亚甲基基团等；p、q、r和s每个为0至5，但要求p+q和r+s分别在0至5的范围内；通过使钯化合物作用于新型2,2-(二芳基)乙烯膦化合物而获得的钯-膦催化剂；以及在钯-膦催化剂存在下获得芳胺、二芳基和芳基炔的方法。

  公开号：

  US20020058837A1
• 作为产物：
  描述：

  1,1-bis(4-methoxypheny)ethanol 在 Ca zeolite 、 对甲苯磺酸 作用下， 以 乙醚 、 正己烷 、 苯 为溶剂， 反应 4.0h， 生成 1,1-bis(4-methoxyphenyl)propanol
  参考文献：
  名称：

  Activation Conditions Play a Key Role in the Activity of Zeolite CaY:  NMR and Product Studies of Brønsted Acidity

  摘要：

  CaY, activated under different conditions, was characterized with H-1, (31)p, and H-1/27AI double resonance MAS NMR. The H-1 MAS NMR spectra of CaY, calcined in an oven at 500 degrees C, shows resonances from H2O (bound to Ca2+ and the zeolite framework), CaOH+, aluminum hydroxides, silanols, and Bronsted acid sites. No evidence for Lewis acidity is observed on adsorption of trimethylphosphine, and an estimate of approximate to 16 Bronsted acid sites per unit cell is obtained for this sample. CaY activated in an oven at higher temperatures contains less water, but all the other species are still present. In contrast, CaY activated by slow ramping of the temperature under vacuum to 500 or 600 degrees C shows a; much lower concentration of Bronsted acid sites (<1/unit cell). Again, no evidence for Lewis acidity was observed. These NMR results have been utilized to understand the very different product distributions that are observed for reactions of 1,1- and 1,2-diarylethylenes in zeolite CaY activated in an oven (in air) and under vacuum. Samples with high concentrations of Bronsted acid sites react stoichiometrically with these sites, yielding diarylalkanes. At low concentrations, the Bronsted acid sites can act catalytically resulting in isomerization reactions.

  DOI：

  10.1021/jp980385w

文献信息

• Asymmetric Addition of Arylboronic Acids to Cumulene Derivatives Catalyzed by Axially Chiral N-Heterocyclic Carbene-Pd2+ Complexes
  作者：Zhen Liu、Peng Gu、Min Shi

  DOI：10.1002/chem.201100703

  日期：2011.5.16

  Cumulene+carbene=chirality! Asymmetric additions of boronic acids to cumulene derivatives, catalyzed by an N‐heterocyclic carbene–palladium complex, provide the desired allenic products in good to excellent yields and moderate to good enantioselectivities. These optically active allenic adducts can be further transformed to useful chiral products in good yields and with an intact chirality (see scheme)

  异丙苯+卡宾=手性！N杂环卡宾-钯络合物催化将硼酸不对称地添加到异丙苯衍生物中，可提供所需的烯丙基产物，其收率良好至优异，对映选择性中等至良好。这些光学活性的烯丙基加合物可以以高收率和完整的手性被进一步转化为有用的手性产物（参见方案）。
• 2,2(diarlyl)vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst
  申请人：Takasago International Corporation

  公开号：US06455720B1

  公开（公告）日：2002-09-24

  A novel 2,2-(diaryl)vinylphosphine compound represented by the following general formula (1): (wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc.; R2, R3, R4, R5, R6, and R7 may be the same or different and each is an alkyl group having 1 to 6 carbon atoms, an alicyclic group having 5 to 7 carbon atoms, etc., provided that R4 and R5 taken together and/or R6 and R7 taken together may represent a fused benzene ring, a substituted fused benzene ring, a trimethylene group, etc.; and p, q, r, and s each is 0 to 5, provided that p+q and r+s each is in the range of from 0 to 5); a palladium-phosphine catalyst obtained by causing a palladium compound to act on the novel 2,2-(diaryl)vinylphosphine compound; and a process for obtaining an arylamine, a diaryl and an arylalkyne in the presence of the palladium-phosphine catalyst.

  下列通用式（1）所代表的新型2,2-(二芳基)乙烯基膦化合物：（其中R1为氢原子、具有1至6个碳原子的烷基、具有5至7个碳原子的脂环族基等；R2、R3、R4、R5、R6和R7可以相同也可以不同，每个都是具有1至6个碳原子的烷基、具有5至7个碳原子的脂环族基等，前提是R4和R5共同取代和/或R6和R7共同取代可以表示为融合苯环、取代融合苯环、三亚甲基基团等；p、q、r和s每个都为0至5，前提是p+q和r+s每个都在0至5的范围内）；由于将钯化合物作用于新型2,2-(二芳基)乙烯基膦化合物而获得的钯膦催化剂；以及在钯膦催化剂的存在下获得芳胺、二芳基和芳基炔的过程。
• Characterization of Persistent Intermediates Generated upon Inclusion of 1,1-Diarylethylenes within CaY Zeolite:  Spectroscopy and Product Studies
  作者：P. Lakshminarasimhan、K. J. Thomas、L. Brancaleon、P. D. Wood、L. J. Johnston、V. Ramamurthy

  DOI：10.1021/jp990913j

  日期：1999.10.1

  Inclusion of 1,1-diarylethylenes within activated CaY results in the formation of colored samples that are stable for prolonged periods. For example, diphenylethylene generates a green color within CaY. Two reactive intermediates have been shown to be responsible for this color. The species with the short wavelength (lambda(max) 410 nm) absorption has been established to be the diphenylmethyl cation. The identity of the species with the long wavelength ((lambda(max) 620 nm) absorption has been debated for three decades. We establish that the diarylethylene radical cation is not responsible for the long wavelength absorption. Laser flash photolysis studies show that a number of diarylethylene radical cations have a characteristic absorption in the 400 nm region in both solution and in NaY zeolite. The absence of this absorption for diarylethylene-CaY samples unequivocally eliminates the possibility that these radical cations are responsible for color formation. This is substantiated by the fact that a number of 2-methyl-substituted 1,1-diarylethylenes generate only the short wavelength cation absorption upon inclusion in CaY; radical cation formation would be expected to be equally facile for the methyl-substituted derivatives. Our results suggest that an allylic dimer cation is the most likely source of the long wavelength ((lambda(max) 620 nm) absorption within CaY.
• 2,2-(Diaryl)vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst
  申请人：Takasago International Corporation

  公开号：EP1167372B1

  公开（公告）日：2003-12-10
• US6455720B1
  申请人：——

  公开号：US6455720B1

  公开（公告）日：2002-09-24